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anti-ADAMTS2 antibody :: Mouse anti-Bovine A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2082091 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) anti-ADAMTS2 antibody
Unit / Price
0.1 mg  /  $795 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2), Monoclonal Antibody

 Also Known As   

APC/CY7-Linked Monoclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2)

 Product Gene Name   

anti-ADAMTS2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AJ003125 mRNA
 3D Structure    ModBase 3D Structure for O95450
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 Clonality    Monoclonal
 Host    Mouse
 Species Reactivity    Bovine
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 Concentration    500ug/ml (lot specific)
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 Immunogen    Gln474~Pro610
 Conjugation    APC-Cy7
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 Other Notes    Small volumes of anti-ADAMTS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ADAMTS2 antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunoprecipitation (IP), ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for ADAMTS2. It may not necessarily be applicable to this product.
 NCBI GI #    110825974
 NCBI GeneID    9509
 NCBI Accession #    NP_055059.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_014244.4 [Other Products]
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 UniProt Primary Accession #    O95450 [Other Products]
 UniProt Related Accession #    O95450 [Other Products]
 Molecular Weight    61,756 Da
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 2 isoform 1 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif 2
 NCBI Official Symbol    ADAMTS2 [Similar Products]
 NCBI Official Synonym Symbols   
NPI; PNPI; PCINP; PCPNI; PCI-NP; PC I-NP; ADAM-TS2; ADAMTS-2; ADAMTS-3
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 2
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 2
 UniProt Synonym Protein Names   
Procollagen I N-proteinase; PC I-NP; Procollagen I/II amino propeptide-processing enzyme; Procollagen N-endopeptidase; pNPI
 Protein Family    A disintegrin and metalloproteinase with thrombospondin motifs
 UniProt Gene Name    ADAMTS2 [Similar Products]
 UniProt Synonym Gene Names    PCINP; PCPNI; ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP; pNPI [Similar Products]
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 NCBI Summary for ADAMTS2    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase. This proteinase excises the N-propeptide of the fibrillar procollagens types I-III and type V. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
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 UniProt Comments for ADAMTS2    ADAMTS2: Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis. Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type 7C (EDS7C). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7C is marked by extremely fragile tissues, hyperextensible skin and easy bruising. Facial skin contains numerous folds, as in the cutis laxa syndrome. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.14; Extracellular matrix; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: extracellular region

Molecular Function: metalloendopeptidase activity; metallopeptidase activity

Disease: Ehlers-danlos Syndrome, Type Vii, Autosomal Recessive
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 Research Articles on ADAMTS2    1. Data indicate that ADAMTS2 and 3 cleave the amino-propeptide of fibrillar collagens and regulate blood vessels homeostasis and lymphangiogenesis. Also, ADAMTS2 deficiency leads to the dermatosparactic type of Ehlers-Danlos syndrome. [review]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ADAMTS2 antibodyDiseases associated with anti-ADAMTS2 antibody
 Products by Pathway  Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >9 publications with ADAMTS2 and Congenital Abnormalities
 Neoplasms Antibodies  >3 publications with ADAMTS2 and Neoplasms
 Bone Diseases, Developmental Antibodies  >2 publications with ADAMTS2 and Bone Diseases, Developmental
 Carcinoma Antibodies  >2 publications with ADAMTS2 and Carcinoma
 Drug-Induced Liver Injury, Chronic Antibodies  >1 publications with ADAMTS2 and Drug-Induced Liver Injury, Chronic
 Inflammation Antibodies  >1 publications with ADAMTS2 and Inflammation
 Recurrence Antibodies  >1 publications with ADAMTS2 and Recurrence
 Heart Defects, Congenital Antibodies  >1 publications with ADAMTS2 and Heart Defects, Congenital
 Liver Cirrhosis Antibodies  >1 publications with ADAMTS2 and Liver Cirrhosis
 Thyroid Neoplasms Antibodies  >1 publications with ADAMTS2 and Thyroid Neoplasms
Organs/Tissues associated with anti-ADAMTS2 antibody
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >8 publications with ADAMTS2 and Connective Tissue
 Skin Antibodies  >6 publications with ADAMTS2 and Skin
 Mouth Antibodies  >3 publications with ADAMTS2 and Mouth
 Embryonic Tissue Antibodies  >2 publications with ADAMTS2 and Embryonic Tissue
 Bone Antibodies  >2 publications with ADAMTS2 and Bone
 Placenta Antibodies  >2 publications with ADAMTS2 and Placenta
 Lung Antibodies  >2 publications with ADAMTS2 and Lung
 Eye Antibodies  >2 publications with ADAMTS2 and Eye
 Heart Antibodies  >1 publications with ADAMTS2 and Heart
 Brain Antibodies  >1 publications with ADAMTS2 and Brain
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