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anti-ADAMTS4 antibody :: Mouse anti-Human A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2001335 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Western Blot (WB)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $145 +1 FREE 8GB USB
0.1 mg  /  $185 +1 FREE 8GB USB
0.2 mg  /  $235 +1 FREE 8GB USB
1 mg  /  $540 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4), Monoclonal Antibody

★Popular Item★
 Also Known As   

Monoclonal Antibody to A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4)

 Product Gene Name   

anti-ADAMTS4 antibody

[Similar Products]
 Matching Pairs    Antibody: A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) Clone #1# (MBS2001335)
Antigen: A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) (MBS2009500)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) Clone #1# (MBS2001335)
Biotin Conjugated Secondary Antibody: IgG (MBS2086030)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) Clone #1# (MBS2001335)
FITC Conjugated Secondary Antibody: IgG (MBS2086031)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) Clone #1# (MBS2001335)
Biotin Conjugated Secondary Antibody: IgG (MBS2086033)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) Clone #1# (MBS2001335)
FITC Conjugated Secondary Antibody: IgG (MBS2086034)
 Matching Pairs    Unconjugated Antibody: A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) Clone #1# (MBS2001335)
HRP Conjugated Secondary Antibody: IgG (MBS2086035)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2001335 Technical Datasheet    Technical Datasheet PDF
 Immunogen Sequence    Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-TFPG KDYDADRQCQ LTFGPDSRHC PQLPPPCAAL WCSGHLNGHA MCQTKHSPWA DGTPCGPAQA CMGGRCLHMD QLQDFNIPQA GGWGPWGPWG
 OMIM    AF148213 mRNA
 3D Structure    ModBase 3D Structure for O75173
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 Clonality    Monoclonal
 Isotype    IgG1 Kappa
 Clone Number    1#
 Host    Mouse
 Species Reactivity    Human
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 Specificity    The antibody is a mouse monoclonal antibody raised against ADAMTS4. It has been selected for its ability to recognize ADAMTS4 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Protein A + Protein G affinity chromatography
 Form/Format    Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300,50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Organism Species    Homo sapiens (Human)
 Source    Monoclonal antibody preparation
 Traits    Liquid
 Immunogen    Recombinant ADAMTS4 (Thr437~Pro575 (Accession # O75173)) expressed in E.coli
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 4C for frequent use.
Aliquot and store at -20C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and noobvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-ADAMTS4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ADAMTS4 antibody   

WB; IHC; ICC; IP.

 Application Notes for anti-ADAMTS4 antibody    Western blotting: 0.5-2 Ug/mL;1:500-2000
Immunohistochemistry: 5-20 Ug/mL;1:50-200
Immunocytochemistry: 5-20 Ug/mL;1:50-200

Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-ADAMTS4 antibody    (Figure. Western Blot; Sample: Recombinant ADAMTS4, Human.)
anti-ADAMTS4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ADAMTS4. It may not necessarily be applicable to this product.
 NCBI GI #    998614223
 NCBI GeneID    9507
 NCBI Accession #    NP_001307265.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001320336.1 [Other Products]
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 UniProt Primary Accession #    O75173 [Other Products]
 UniProt Secondary Accession #    Q2HYD0; Q5VTW2; Q6P4Q8; Q6UWA8; Q9UN83 [Other Products]
 UniProt Related Accession #    O75173 [Other Products]
 Molecular Weight    90,065 Da
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 4 isoform 2
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif 4
 NCBI Official Symbol    ADAMTS4 [Similar Products]
 NCBI Official Synonym Symbols   
ADMP-1; ADAMTS-2; ADAMTS-4
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 4
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 4
 UniProt Synonym Protein Names   
ADMP-1; Aggrecanase-1
 Protein Family    A disintegrin and metalloproteinase with thrombospondin motifs
 UniProt Gene Name    ADAMTS4 [Similar Products]
 UniProt Synonym Gene Names    KIAA0688; ADAM-TS 4; ADAM-TS4; ADAMTS-4 [Similar Products]
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 NCBI Summary for ADAMTS4    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
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 UniProt Comments for ADAMTS4    ADAMTS4: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

Protein type: EC 3.4.24.82; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: extracellular matrix; extracellular region; extracellular space; nuclear speck; proteinaceous extracellular matrix

Molecular Function: metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protease binding; protein binding; zinc ion binding

Biological Process: extracellular matrix disassembly; proteolysis; skeletal system development
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 Research Articles on ADAMTS4    1. ADAMTS-4 protein expression increased in cartilage tissue from spinal tuberculosis patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADAMTS4 antibodyPathways associated with anti-ADAMTS4 antibody
 Reference Product  PubMed Publications
 ACAN antibody  >18 publications with ADAMTS4 and ACAN
 TIMP3 antibody  >15 publications with ADAMTS4 and TIMP3
 TGFB1 antibody  >12 publications with ADAMTS4 and TGFB1
 IL6 antibody  >10 publications with ADAMTS4 and IL6
 FURIN antibody  >7 publications with ADAMTS4 and FURIN
 IL1B antibody  >5 publications with ADAMTS4 and IL1B
 BCAN antibody  >5 publications with ADAMTS4 and BCAN
 SRPX2 antibody  >2 publications with ADAMTS4 and SRPX2
 FGF18 antibody  >1 publications with ADAMTS4 and FGF18
 Products by Pathway  Pathway Diagram
 Defective B3GALTL Causes Peters-plus Syndrome (PpS) Pathway antibodies  Defective B3GALTL Causes Peters-plus Syndrome (PpS) Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With O-glycosylation Of Proteins Pathway antibodies  Diseases Associated With O-glycosylation Of Proteins Pathway Diagram
 Diseases Of Glycosylation Pathway antibodies  Diseases Of Glycosylation Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-glycosylation Of TSR Domain-containing Proteins Pathway antibodies  O-glycosylation Of TSR Domain-containing Proteins Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram
Diseases associated with anti-ADAMTS4 antibodyOrgans/Tissues associated with anti-ADAMTS4 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >47 publications with ADAMTS4 and Inflammation
 Necrosis Antibodies  >45 publications with ADAMTS4 and Necrosis
 Disease Models, Animal Antibodies  >39 publications with ADAMTS4 and Disease Models, Animal
 Nervous System Diseases Antibodies  >27 publications with ADAMTS4 and Nervous System Diseases
 Atherosclerosis Antibodies  >11 publications with ADAMTS4 and Atherosclerosis
 Heart Diseases Antibodies  >9 publications with ADAMTS4 and Heart Diseases
 Myocardial Infarction Antibodies  >6 publications with ADAMTS4 and Myocardial Infarction
 Liver Diseases Antibodies  >5 publications with ADAMTS4 and Liver Diseases
 Weight Loss Antibodies  >4 publications with ADAMTS4 and Weight Loss
 Hypertrophy Antibodies  >4 publications with ADAMTS4 and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >27 publications with ADAMTS4 and Brain
 Muscle Antibodies  >16 publications with ADAMTS4 and Muscle
 Embryonic Tissue Antibodies  >7 publications with ADAMTS4 and Embryonic Tissue
 Adipose Tissue Antibodies  >6 publications with ADAMTS4 and Adipose Tissue
 Lung Antibodies  >3 publications with ADAMTS4 and Lung
 Placenta Antibodies  >2 publications with ADAMTS4 and Placenta
 Larynx Antibodies  >1 publications with ADAMTS4 and Larynx
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