NP_000385
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
alpha-crystallin A chain
NCBI Official Synonym Full Names
crystallin alpha A
NCBI Protein Information
alpha-crystallin A chain
UniProt Protein Name
Alpha-crystallin A chain
UniProt Synonym Protein Names
Heat shock protein beta-4; HspB4
UniProt Synonym Gene Names
NCBI Summary for CRYAA
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq, Jan 2014]
UniProt Comments for CRYAA
Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
Product References and Citations for anti-CRYAA antibody
Fujii N., et al., (2003) Mol. Vis. 9: 915-22; Laksanalamai P., et al., (2004) Extremophiles 8: 1-11
Research Articles on CRYAA
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Products associated with anti-CRYAA antibody
Pathways associated with anti-CRYAA antibody
Organs/Tissues associated with anti-CRYAA antibody
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