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anti-A1 antibody :: Mouse anti-Human A1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS200362
Western Blot (WB)
Unit / Price
0.05 mL  /  $240 +1 FREE 8GB USB
0.1 mL  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A1, Monoclonal Antibody

 Also Known As   

A1 antibody

 Product Synonym Names    Annexin-1; Lipocortin I; Calpactin II; Chromobindin-9; p35; ANXA1; ANX1; LPC1; Annexin I; AnnexinA1; AnnexinI; ANX 1; ANX A1; ANXA 1; ANXA1 protein; CalpactinII; Chromobindin 9; Chromobindin9; HGNC:533; Lipocortin 1; Lipocortin I; Lipocortin1; LipocortinI; LPC 1; Phospholipase A2 inhibitory protein
 Product Gene Name   

anti-A1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    X05908 mRNA
 3D Structure    ModBase 3D Structure for P04083
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 Clonality    Monoclonal
 Isotype    IgG1, k
 Clone Number    AT2G5
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    By protein-A affinity chromatography
 Form/Format    Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
 Concentration    1 mg/ml (lot specific)
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 Antigen Species    Human
 Immunogen    Recombinant human Annexin A1 (1-346aa) purified from E Coli.
 Clone Note    Anti-human Annexin A1 mAb, clone AT2G5, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human Annexin A1 protein.
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 Preparation and Storage    Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of anti-A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-A1 antibody

   Annexin A1, also known as Lipocortin I, belongs to a family of Ca (2+)-dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. It promotes membrane fusion and is also involved in exocytosis. Since Annexin A1 has phospholipase A2 inhibitory activity to bind from two to four calcium ions with high affinity, this protein may have potential anti-inflammatory activity. The detection of this protein by immunocytochemical means reportedly provides a simple, highly sensitive and specific assay for diagnosis of hairy cell leukemia.
 Product Categories/Family for anti-A1 antibody    Serology; Transportation; Metabolism; Apoptosis
 Applications Tested/Suitable for anti-A1 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-A1 antibody    Recommended starting dilution is 1:3000-1:20000.
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 Western Blot (WB) of anti-A1 antibody    Western blot analysis The Recombinant Human Annexin A1 (10ng) and Cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human Annexin A1 antibody (1:3000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: Recombinant Human Annexin A1 Lane 2.: HeLa cell lysate Lane 3.: A549 cell lysate Lane 4.: A431 cell lysate The HeLa cell lysate (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human Annexin A1 antibody. Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: Anti- Annexin A1 antibody (1:10000) Lane 2.: Anti- Annexin A1 antibody (1:20000)
anti-A1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for A1. It may not necessarily be applicable to this product.
 NCBI GI #    4502101
 NCBI GeneID    301
 NCBI Accession #    NP_000691 [Other Products]
 NCBI GenBank Nucleotide #    NM_000700.2 [Other Products]
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 UniProt Primary Accession #    P04083 [Other Products]
 UniProt Related Accession #    P04083 [Other Products]
 Molecular Weight    38,714 Da
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 NCBI Official Full Name    annexin A1
 NCBI Official Synonym Full Names    annexin A1
 NCBI Official Symbol    ANXA1 [Similar Products]
 NCBI Official Synonym Symbols   
ANX1; LPC1
[Similar Products]
 NCBI Protein Information    annexin A1
 UniProt Protein Name    Annexin A1
 UniProt Synonym Protein Names   
Annexin I; Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; Lipocortin I
 Protein Family    A1-specific pheromone
 UniProt Gene Name    ANXA1 [Similar Products]
 UniProt Synonym Gene Names    ANX1; LPC1 [Similar Products]
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 NCBI Summary for A1    This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
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 UniProt Comments for A1    Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity (PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (). Promotes resolution of inflammation and wound healing (PubMed:25664854). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades (PubMed:15187149, PubMed:25664854). Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (PubMed:15187149). Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells (PubMed:17008549). Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells (PubMed:17008549). Has no effect on unstimulated T cells (PubMed:17008549). Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration (PubMed:15187149). Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton (PubMed:19625660). Has high affinity for Ca2+ and can bind up to eight Ca2+ ions (). Displays Ca2+-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca2+-dependent interaction between phagosomes and the actin cytoskeleton ().
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Product References and Citations for anti-A1 antibody

   Lim L.H., et al. (2007) FASEB J. 21 (4): 968-975; Kovacic R.T., et al. (1991) Biochemistry. 30 (37): 9015-9021
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 Research Articles on A1    1. Data indicate a regulatory circuit between ANXA1, NF-kB, c-myc and miR-196a which regulates breast cancer cell proliferation and tumor growth.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-A1 antibodyPathways associated with anti-A1 antibody
 Reference Product  PubMed Publications
 ANXA2 antibody  >47 publications with A1 and ANXA2
 FPR2 antibody  >41 publications with A1 and FPR2
 FPR1 antibody  >20 publications with A1 and FPR1
 POMC antibody  >13 publications with A1 and POMC
 FPR3 antibody  >4 publications with A1 and FPR3
 ADCY2 antibody  >1 publications with A1 and ADCY2
 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway antibodies  Formyl Peptide Receptors Bind Formyl Peptides And Many Other Ligands Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
Diseases associated with anti-A1 antibodyOrgans/Tissues associated with anti-A1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >132 publications with A1 and Inflammation
 Carcinoma Antibodies  >79 publications with A1 and Carcinoma
 Disease Models, Animal Antibodies  >44 publications with A1 and Disease Models, Animal
 Breast Neoplasms Antibodies  >33 publications with A1 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >28 publications with A1 and Neoplasm Metastasis
 Carcinoma, Squamous Cell Antibodies  >25 publications with A1 and Carcinoma, Squamous Cell
 Necrosis Antibodies  >20 publications with A1 and Necrosis
 Neoplasm Invasiveness Antibodies  >19 publications with A1 and Neoplasm Invasiveness
 Lung Neoplasms Antibodies  >16 publications with A1 and Lung Neoplasms
 Liver Diseases Antibodies  >14 publications with A1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >143 publications with A1 and Blood
 Brain Antibodies  >45 publications with A1 and Brain
 Lung Antibodies  >40 publications with A1 and Lung
 Vascular Antibodies  >32 publications with A1 and Vascular
 Liver Antibodies  >26 publications with A1 and Liver
 Muscle Antibodies  >19 publications with A1 and Muscle
 Stomach Antibodies  >17 publications with A1 and Stomach
 Pituitary Gland Antibodies  >16 publications with A1 and Pituitary Gland
 Bone Antibodies  >15 publications with A1 and Bone
 Lymph Node Antibodies  >15 publications with A1 and Lymph Node
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