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anti-A2M antibody :: Mouse anti-Mouse A2M Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9200404
Western Blot (WB)
Unit / Price
0.1 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A2M, Monoclonal Antibody

 Also Known As   

A2M Antibody (C-term) (Ascites)

 Product Synonym Names    Alpha-2-macroglobulin; Alpha-2-M; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; A2M; CPAMD5
 Product Gene Name   

anti-A2M antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    1162-1192
 OMIM    103950
 3D Structure    ModBase 3D Structure for P01023
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 Clonality    Monoclonal
 Isotype    IgM
 Clone Number    590CT15.5.5
 Host    Mouse
 Species Reactivity    Mouse
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 Specificity    This A2M antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 1162-1192 amino acids from the C-terminal region of human A2M.
 Form/Format    Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-A2M antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-A2M antibody

   Alpha-2-macroglobulin is a protease inhibitor and cytokine
transporter. It inhibits many proteases, including trypsin,
thrombin and collagenase. A2M is implicated in Alzheimer disease
(AD) due to its ability to mediate the clearance and degradation of
A-beta, the major component of beta-amyloid deposits. [provided by
RefSeq].
 Product Categories/Family for anti-A2M antibody    Cardiovascular; Cell Biology
 Applications Tested/Suitable for anti-A2M antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-A2M antibody    WB~~1:100~200
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 Western Blot (WB) of anti-A2M antibody    A2M Antibody (C-term)(Ascites) western blot analysis in mouse Liver tissue lysates (35ug/lane).This demonstrates the A2M antibody detected the A2M protein (arrow).
anti-A2M antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for A2M. It may not necessarily be applicable to this product.
 NCBI GI #    66932947
 NCBI GeneID    2
 NCBI Accession #    NP_000005.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000014.4 [Other Products]
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 UniProt Primary Accession #    P01023 [Other Products]
 UniProt Secondary Accession #    Q13677; Q59F47; Q5QTS0; Q68DN2; Q6PIY3; Q6PN97 [Other Products]
 UniProt Related Accession #    P01023 [Other Products]
 Molecular Weight    163291
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 NCBI Official Full Name    alpha-2-macroglobulin
 NCBI Official Synonym Full Names    alpha-2-macroglobulin
 NCBI Official Symbol    A2M [Similar Products]
 NCBI Official Synonym Symbols   
A2MD; CPAMD5; FWP007; S863-7
[Similar Products]
 NCBI Protein Information    alpha-2-macroglobulin
 UniProt Protein Name    Alpha-2-macroglobulin
 UniProt Synonym Protein Names   
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5
 Protein Family    Alpha-2-macroglobulin
 UniProt Gene Name    A2M [Similar Products]
 UniProt Synonym Gene Names    CPAMD5; Alpha-2-M [Similar Products]
 UniProt Entry Name    A2MG_HUMAN
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 NCBI Summary for A2M    Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]
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 UniProt Comments for A2M    A2M: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family.

Protein type: Secreted; Secreted, signal peptide; Inhibitor

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: extracellular region; cytosol

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; protease binding; growth factor binding; interleukin-1 binding; interleukin-8 binding; calcium-dependent protein binding; tumor necrosis factor binding; receptor binding

Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; extracellular matrix disassembly; regulation of small GTPase mediated signal transduction; extracellular matrix organization and biogenesis; platelet degranulation; small GTPase mediated signal transduction; stem cell differentiation; blood coagulation; blood coagulation, intrinsic pathway

Disease: Alzheimer Disease; Alpha-2-macroglobulin Deficiency
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Product References and Citations for anti-A2M antibody

   Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Bruno, E., et al. Neurosci. Lett. 482(2):112-116(2010)
Nalpas, B., et al. Gut 59(8):1120-1126(2010)
Song, H., et al. Neurosci. Lett. 479(2):143-145(2010)
Seriramalu, R., et al. Electrophoresis 31(14):2388-2395(2010)
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 Research Articles on A2M    1. phosphorylating the T-loop Akt residue Thr(308) by PDK1 requires Raptor of the mTORC1 complex as a platform or scaffold protein.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to A2M Antibody (C-term) (Ascites)
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 MBS7221413  Sheep Alpha-2-macroglobulin-like protein 1 (A2ML1) ELISA Kit  MBS2050551  Cy3-Linked Polyclonal Antibody to Alpha-2-Macroglobulin (a2M)
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Products associated with anti-A2M antibodyPathways associated with anti-A2M antibody
 Reference Product  PubMed Publications
 APP antibody  >17 publications with A2M and APP
 ALB antibody  >6 publications with A2M and ALB
 APOA1 antibody  >4 publications with A2M and APOA1
 TGFB1 antibody  >3 publications with A2M and TGFB1
 PLG antibody  >2 publications with A2M and PLG
 SERPINA1 antibody  >1 publications with A2M and SERPINA1
 Products by Pathway  Pathway Diagram
 Superpathway Of Branched Amino Acid Biosynthesis antibodies  Superpathway Of Branched Amino Acid Biosynthesis Diagram
 Superpathway Of Branched Amino Acid Biosynthesis antibodies  Superpathway Of Branched Amino Acid Biosynthesis Diagram
 Superpathway Of Branched Amino Acid Biosynthesis antibodies  Superpathway Of Branched Amino Acid Biosynthesis Diagram
 Superpathway Of Branched Amino Acid Biosynthesis antibodies  Superpathway Of Branched Amino Acid Biosynthesis Diagram
 Superpathway Of Branched Amino Acid Biosynthesis antibodies  Superpathway Of Branched Amino Acid Biosynthesis Diagram
 Superpathway Of Branched Amino Acid Biosynthesis antibodies  Superpathway Of Branched Amino Acid Biosynthesis Diagram
 Superpathway Of Branched Amino Acid Biosynthesis antibodies  Superpathway Of Branched Amino Acid Biosynthesis Diagram
 Superpathway Of Branched Amino Acid Biosynthesis antibodies  Superpathway Of Branched Amino Acid Biosynthesis Diagram
 Superpathway Of Branched Amino Acid Biosynthesis antibodies  Superpathway Of Branched Amino Acid Biosynthesis Diagram
 Superpathway Of Branched Amino Acid Biosynthesis antibodies  Superpathway Of Branched Amino Acid Biosynthesis Diagram
Diseases associated with anti-A2M antibodyOrgans/Tissues associated with anti-A2M antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >96 publications with A2M and Nervous System Diseases
 Mental Disorders Antibodies  >84 publications with A2M and Mental Disorders
 Alzheimer Disease Antibodies  >82 publications with A2M and Alzheimer Disease
 Inflammation Antibodies  >32 publications with A2M and Inflammation
 Liver Diseases Antibodies  >15 publications with A2M and Liver Diseases
 Necrosis Antibodies  >14 publications with A2M and Necrosis
 Lung Diseases Antibodies  >14 publications with A2M and Lung Diseases
 Disease Models, Animal Antibodies  >12 publications with A2M and Disease Models, Animal
 Fibrosis Antibodies  >11 publications with A2M and Fibrosis
 Carcinoma Antibodies  >9 publications with A2M and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >132 publications with A2M and Blood
 Liver Antibodies  >40 publications with A2M and Liver
 Brain Antibodies  >32 publications with A2M and Brain
 Vascular Antibodies  >17 publications with A2M and Vascular
 Lung Antibodies  >14 publications with A2M and Lung
 Prostate Antibodies  >10 publications with A2M and Prostate
 Heart Antibodies  >9 publications with A2M and Heart
 Ovary Antibodies  >7 publications with A2M and Ovary
 Uterus Antibodies  >6 publications with A2M and Uterus
 Bone Antibodies  >6 publications with A2M and Bone
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