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anti-ABCA7 antibody :: Rat ABCA7 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS217356
Unit / Price
0.25 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCA7, Monoclonal Antibody

 Also Known As   

RAT ANTI MOUSE ABCA7

 Product Gene Name   

anti-ABCA7 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q91V24
 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    4A7-144.1
 Host    Rat
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
Preparation
 Immunogen    ABCA7 transfected HeLa cells
Buffer Solution
 Target Species    Mouse
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-ABCA7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ABCA7 antibody

   Rat anti Mouse ABCA7 antibody, clone 4A7-144.1 recognizes murine adenosine triphosphate (ATP) Binding cassette transporter 7 (ABCA7). The ABC transporters are a large family of conserved proteins that transport a wide variety of molecules across cellular membranes. ABCA7 is a member of the ABC-A sub-family, which is predominantly expressed in the thymus and in other immune and haematopoietic tissues. The exact physiological function of ABCA7 is unknown, although the molecule shows the highest homology to ABCA1 and may play a similar role in lipid homeostasis.
 Applications Tested/Suitable for anti-ABCA7 antibody   

Flow cytometry (FC/FACS)

 Application Notes for anti-ABCA7 antibody    Flow Cytometry: Use 10ul of the suggested working dilution to label 1x106 cells in 100ul.
Flow Cytometry: Minimum Dilution: Neat; Maximum Dilution: 1/10
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 Testing Data #1 of anti-ABCA7 antibody    Staining of mouse thymus with Rat anti Mouse ABCA7: Alexa Fluor 647
anti-ABCA7 antibody Testing Data #1 image
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 Testing Data #2 of anti-ABCA7 antibody    Staining of mouse spleen with Rat anti Mouse ABCA7 (MBS217356)
anti-ABCA7 antibody Testing Data #2 image
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 Testing Data #3 of anti-ABCA7 antibody    Staining of mouse spleen with Rat anti Mouse ABCA7: Alexa Fluor 488
anti-ABCA7 antibody Testing Data #3 image
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 Testing Data #4 of anti-ABCA7 antibody    Staining of mouse spleen with Rat anti Mouse ABCA7: RPE (MBS217359)
anti-ABCA7 antibody Testing Data #4 image
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NCBI/Uniprot data below describe general gene information for ABCA7. It may not necessarily be applicable to this product.
 NCBI GI #    15451840
 NCBI GeneID    27403
 NCBI Accession #    NP_038878.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_013850.1 [Other Products]
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 UniProt Primary Accession #    Q91V24 [Other Products]
 UniProt Secondary Accession #    Q9JL36 [Other Products]
 UniProt Related Accession #    Q91V24 [Other Products]
 Molecular Weight    236,884 Da
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 NCBI Official Full Name    ATP-binding cassette sub-family A member 7
 NCBI Official Synonym Full Names    ATP-binding cassette, sub-family A (ABC1), member 7
 NCBI Official Symbol    Abca7 [Similar Products]
 NCBI Official Synonym Symbols   
ABCX; Abc51
[Similar Products]
 NCBI Protein Information    ATP-binding cassette sub-family A member 7
 UniProt Protein Name    ATP-binding cassette sub-family A member 7
 Protein Family    ABC transporter A family
 UniProt Gene Name    Abca7 [Similar Products]
 UniProt Entry Name    ABCA7_MOUSE
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 NCBI Summary for ABCA7    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is widely expressed with highest detection in spleen and hematopoietic tissues. The function of this protein has not yet been determined; however, a related human protein is thought to play a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCA7    ABCA7: Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. Belongs to the ABC transporter superfamily. ABCA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ABC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: Golgi apparatus; cell surface; membrane; intracellular membrane-bound organelle; integral to plasma membrane; apical plasma membrane; cytoplasm; integral to membrane; plasma membrane; intracellular; endosome; phagocytic cup

Molecular Function: protein binding; apolipoprotein A-I receptor activity; phospholipid transporter activity; ATPase activity, coupled to transmembrane movement of substances; transporter activity; cholesterol transporter activity; ATPase activity; nucleotide binding; ATP binding

Biological Process: phospholipid efflux; transport; positive regulation of ATPase activity; negative regulation of amyloid precursor protein biosynthetic process; positive regulation of phagocytosis; cholesterol efflux; phospholipid scrambling; peptide cross-linking; transmembrane transport; negative regulation of ATPase activity; memory; phagocytosis
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 Research Articles on ABCA7    1. Theresults of this study suggested that ABCA7 plays a role in the regulation of Abeta homeostasis in the brain and that this may be related to altered phagocyte function.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ABCA7 antibodyDiseases associated with anti-ABCA7 antibody
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 ABCA Transporters In Lipid Homeostasis Pathway antibodies  ABCA Transporters In Lipid Homeostasis Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Phosphate Acquisition II Pathway antibodies  Phosphate Acquisition II Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >44 publications with ABCA7 and Nervous System Diseases
 Brain Diseases Antibodies  >43 publications with ABCA7 and Brain Diseases
 Alzheimer Disease Antibodies  >43 publications with ABCA7 and Alzheimer Disease
 Disease Progression Antibodies  >6 publications with ABCA7 and Disease Progression
 Cognition Disorders Antibodies  >4 publications with ABCA7 and Cognition Disorders
 Ovarian Neoplasms Antibodies  >2 publications with ABCA7 and Ovarian Neoplasms
 Inflammation Antibodies  >2 publications with ABCA7 and Inflammation
 Skin Diseases Antibodies  >1 publications with ABCA7 and Skin Diseases
 Fibrosis Antibodies  >1 publications with ABCA7 and Fibrosis
 Liver Neoplasms Antibodies  >1 publications with ABCA7 and Liver Neoplasms
Organs/Tissues associated with anti-ABCA7 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >31 publications with ABCA7 and Brain
 Liver Antibodies  >7 publications with ABCA7 and Liver
 Spleen Antibodies  >5 publications with ABCA7 and Spleen
 Kidney Antibodies  >5 publications with ABCA7 and Kidney
 Mammary Gland Antibodies  >4 publications with ABCA7 and Mammary Gland
 Lung Antibodies  >3 publications with ABCA7 and Lung
 Bone Marrow Antibodies  >3 publications with ABCA7 and Bone Marrow
 Bone Antibodies  >3 publications with ABCA7 and Bone
 Thymus Antibodies  >2 publications with ABCA7 and Thymus
 Heart Antibodies  >2 publications with ABCA7 and Heart
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