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anti-ABCB1 antibody :: Mouse anti-Human ABCB1 / MDR1 / P Glycoprotein Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS246685
Immunohistochemistry (IHC)
Unit / Price
0.1 mL  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCB1 / MDR1 / P Glycoprotein, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone JSB-1] (IgG1) to Human ABCB1 / MDR1 / P Glycoprotein

 Product Synonym Names    Anti-ABCB1 / MDR1 / P Glycoprotein Antibody (clone JSB-1) IHC-plus; ABCB1; ABC20; Abcb1b; CLCS; Colchicin sensitivity; CD243; Doxorubicin resistance; IBD13; gp170; MDR1; Multidrug resistance protein 1; P glycoprotein; P-glycoprotein 1; P-GP; CD243 antigen; PGY1; Human ABCB1; MDR1; P Glycoprotein
 Product Gene Name   

anti-ABCB1 antibody

[Similar Products]
 Product Synonym Gene Name    MDR1; P Glycoprotein [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 612244
 3D Structure    ModBase 3D Structure for P08183
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    JSB-1
 Host    Mouse
 Species Reactivity    Human
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 Specificity    The antibody JSB-1 reacts with a conserved cytoplasmic epitope of the plasma membrane-associated 170-180 kD glycoprotein, the expression of which is strongly correlated with the degree of multi-drug-resistance (MDR) derived MDR cell lines and human MDR cell lines, including cell lines derived from lung, ovaries and B cell lymphomas. Cross-reacts with Chinese hamster. No cross-reactivity with mouse or rat.
 Purity/Purification    Tissue culture supernatant
 Form/Format    Tissue culture supernatant, 1% BSA, 0.1% sodium azide
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 Target Species    Human
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-ABCB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ABCB1 antibody

   ABCB1/MDR1/P Glycoprotein is an ATP dependent transporter that mediates efflux of chemotherapeutic agents from the intracellular milieu. P Glycoprotein has also been associated with volume-regulated chloride channel activity and basal to apical transendothelial migration of mononuclear phagocytes.
 Product Categories/Family for anti-ABCB1 antibody    Family: Transporter
Subfamily: ATP-binding cassette - ABCB/MDR
 Applications Tested/Suitable for anti-ABCB1 antibody   

Immunohistochemistry (IHC - Paraffin; IHC - Frozen), Western Blot (WB), Flow Cytometry (FC/FACS)

 Application Notes for anti-ABCB1 antibody    Flo, IHC-Fr, IHC-P (1:50), WB
Usage: JSB-1 has potential value for diagnostic detection of MDR cells in human tumor samples. Working dilutions. Flow cytometry: at least 1:10. Western blotting: start optimizing working dilution a 1:10. Immunocytochemistry: acetone fixed cell preparation...
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 Immunohistochemistry (IHC) of anti-ABCB1 antibody    Anti-MDR1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
anti-ABCB1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ABCB1. It may not necessarily be applicable to this product.
 NCBI GI #    42741659
 NCBI GeneID    5243
 NCBI Accession #    NP_000918.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000927.4 [Other Products]
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 UniProt Primary Accession #    P08183 [Other Products]
 UniProt Secondary Accession #    Q12755; Q14812; A8K294; B5AK60 [Other Products]
 UniProt Related Accession #    P08183 [Other Products]
 Molecular Weight    134,032 Da
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 NCBI Official Full Name    multidrug resistance protein 1
 NCBI Official Synonym Full Names    ATP-binding cassette, sub-family B (MDR/TAP), member 1
 NCBI Official Symbol    ABCB1 [Similar Products]
 NCBI Official Synonym Symbols   
CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170
[Similar Products]
 NCBI Protein Information    multidrug resistance protein 1; P-glycoprotein 1; colchicin sensitivity; doxorubicin resistance
 UniProt Protein Name    Multidrug resistance protein 1
 UniProt Synonym Protein Names   
ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD_antigen: CD243
 Protein Family    ABC transporter B family
 UniProt Gene Name    ABCB1 [Similar Products]
 UniProt Synonym Gene Names    MDR1; PGY1 [Similar Products]
 UniProt Entry Name    MDR1_HUMAN
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 NCBI Summary for ABCB1    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCB1    ABCB1: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8.

Protein type: Transporter, ABC family; Cell adhesion; EC 3.6.3.44; Transporter; Hydrolase; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q21.12

Cellular Component: cell surface; membrane; plasma membrane; integral to membrane

Molecular Function: protein binding; transporter activity; ATPase activity, coupled to transmembrane movement of substances; xenobiotic-transporting ATPase activity; ATP binding

Biological Process: response to drug; transport; multidrug transport; xenobiotic transport; G2/M transition of mitotic cell cycle; transmembrane transport

Disease: Colchicine Resistance; Inflammatory Bowel Disease 13
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 Research Articles on ABCB1    1. This study was undertaken with a view to determine the allele and genotype frequencies of C3435T and C1236T polymorphisms in the ABCB1 gene among the Maharashtrian population, residing in the Vidarbha region of central India.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ABCB1 antibodyPathways associated with anti-ABCB1 antibody
 Reference Product  PubMed Publications
 HIF1A antibody  >53 publications with ABCB1 and HIF1A
 TP53 antibody  >41 publications with ABCB1 and TP53
 SP1 antibody  >34 publications with ABCB1 and SP1
 SLC22A1 antibody  >32 publications with ABCB1 and SLC22A1
 CAV1 antibody  >28 publications with ABCB1 and CAV1
 SLC22A2 antibody  >16 publications with ABCB1 and SLC22A2
 NR1I3 antibody  >13 publications with ABCB1 and NR1I3
 ARNT antibody  >6 publications with ABCB1 and ARNT
 LANCL2 antibody  >1 publications with ABCB1 and LANCL2
 SLC22A3 antibody  >1 publications with ABCB1 and SLC22A3
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Abacavir Transmembrane Transport Pathway antibodies  Abacavir Transmembrane Transport Pathway Diagram
 Abacavir Transport And Metabolism Pathway antibodies  Abacavir Transport And Metabolism Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Codeine And Morphine Metabolism Pathway antibodies  Codeine And Morphine Metabolism Pathway Diagram
 Drug Induction Of Bile Acid Pathway antibodies  Drug Induction Of Bile Acid Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
Diseases associated with anti-ABCB1 antibodyOrgans/Tissues associated with anti-ABCB1 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2347 publications with ABCB1 and Carcinoma
 Breast Neoplasms Antibodies  >1200 publications with ABCB1 and Breast Neoplasms
 Nervous System Diseases Antibodies  >849 publications with ABCB1 and Nervous System Diseases
 Liver Diseases Antibodies  >595 publications with ABCB1 and Liver Diseases
 Colorectal Neoplasms Antibodies  >485 publications with ABCB1 and Colorectal Neoplasms
 Epilepsy Antibodies  >354 publications with ABCB1 and Epilepsy
 Disease Progression Antibodies  >321 publications with ABCB1 and Disease Progression
 Carcinoma, Non-Small-Cell Lung Antibodies  >318 publications with ABCB1 and Carcinoma, Non-Small-Cell Lung
 Kidney Diseases Antibodies  >311 publications with ABCB1 and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >287 publications with ABCB1 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2380 publications with ABCB1 and Brain
 Liver Antibodies  >2038 publications with ABCB1 and Liver
 Kidney Antibodies  >1337 publications with ABCB1 and Kidney
 Intestine Antibodies  >1299 publications with ABCB1 and Intestine
 Vascular Antibodies  >670 publications with ABCB1 and Vascular
 Heart Antibodies  >342 publications with ABCB1 and Heart
 Placenta Antibodies  >197 publications with ABCB1 and Placenta
 Muscle Antibodies  >196 publications with ABCB1 and Muscle
 Prostate Antibodies  >187 publications with ABCB1 and Prostate
 Embryonic Tissue Antibodies  >134 publications with ABCB1 and Embryonic Tissue
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