NP_000918.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
134,032 Da
NCBI Official Full Name
multidrug resistance protein 1
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family B (MDR/TAP), member 1
NCBI Official Synonym Symbols
CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170 [Similar Products]
NCBI Protein Information
multidrug resistance protein 1; P-glycoprotein 1; colchicin sensitivity; doxorubicin resistance
UniProt Protein Name
Multidrug resistance protein 1
UniProt Synonym Protein Names
ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD_antigen: CD243
UniProt Synonym Gene Names
UniProt Entry Name
MDR1_HUMAN
NCBI Summary for ABCB1
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCB1
ABCB1: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8.
Protein type: Transporter, ABC family; Cell adhesion; EC 3.6.3.44; Transporter; Hydrolase; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q21.12
Cellular Component: cell surface; membrane; plasma membrane; integral to membrane
Molecular Function: protein binding; transporter activity; ATPase activity, coupled to transmembrane movement of substances; xenobiotic-transporting ATPase activity; ATP binding
Biological Process: response to drug; transport; multidrug transport; xenobiotic transport; G2/M transition of mitotic cell cycle; transmembrane transport
Disease: Colchicine Resistance; Inflammatory Bowel Disease 13
Research Articles on ABCB1
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Products associated with anti-ABCB1 antibody
Pathways associated with anti-ABCB1 antibody
Diseases associated with anti-ABCB1 antibody
Organs/Tissues associated with anti-ABCB1 antibody
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