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anti-ABCB1 antibody :: Mouse anti-Human ABCB1 / MDR1 / P Glycoprotein Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS249484
Unit / Price
0.05 mL  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ABCB1 / MDR1 / P Glycoprotein, Monoclonal Antibody

 Also Known As   

Anti-ABCB1 / MDR1 / P Glycoprotein Antibody (clone 6H2) IHC-plus

 Product Synonym Names    Mouse Monoclonal [clone 6H2] (IgG2a) to Human ABCB1 / MDR1 / P Glycoprotein; Human ABCB1 / MDR1 / P Glycoprotein; ABC20; Abcb1b; CLCS; Colchicin sensitivity; CD243; Doxorubicin resistance; IBD13; gp170; MDR1; Multidrug resistance protein 1; P glycoprotein; P-glycoprotein 1; P-GP; CD243 antigen; PGY1
 Product Gene Name   

anti-ABCB1 antibody

[Similar Products]
 Product Synonym Gene Name    MDR1 / P Glycoprotein [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    171050
 3D Structure    ModBase 3D Structure for P08183
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    6H2
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Human ABCB1 / MDR1
 Purity/Purification    Protein A/G purified
 Form/Format    PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
 Concentration    1 mg/ml (lot specific)
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 Immunogen    ABCB1 / MDR1 / P Glycoprotein antibody was raised against human recombinant protein fragment corresponding to amino acids 995-1280 of human ABCB1 (NP_000918) produced in SF9 cell.
 Immunogen Description    Human recombinant protein fragment corresponding to amino acids 995-1280 of human ABCB1 (NP_000918) produced in SF9 cell.
 Immunogen Type    Recombinant protein
 Target Species    Human
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 Preparation and Storage    Store at -20 degree C. Minimize freezing and thawing.
 Other Notes    Small volumes of anti-ABCB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ABCB1 antibody

   ABCB1 Antibody, ABC20 Antibody, Abcb1b Antibody, CLCS Antibody, Colchicin sensitivity Antibody, CD243 Antibody, Doxorubicin resistance Antibody, IBD13 Antibody, gp170 Antibody, MDR1 Antibody, Multidrug resistance protein 1 Antibody, P glycoprotein Antibody, P-glycoprotein 1 Antibody, P-GP Antibody, CD243 antigen Antibody, PGY1 Antibody Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance.
 Applications Tested/Suitable for anti-ABCB1 antibody   

Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

 Application Notes for anti-ABCB1 antibody    IHC-P (10 ug/ml)
WB (1:1000)
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 Immunohistochemistry (IHC) of anti-ABCB1 antibody    Anti-ABCB1 / MDR1 / P Glycoprotein antibody IHC staining of human vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-ABCB1 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-ABCB1 antibody    Western blot of extracts (15 ug) from 4 different cell lines by using anti-ABCB1 monoclonal antibody (Lane 1: 293T; Lane 2: UO_31; Lane 3: HCT_115; Lane 4: HeLa).
anti-ABCB1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ABCB1. It may not necessarily be applicable to this product.
 NCBI GI #    42741659
 NCBI GeneID    5243
 NCBI Accession #    NP_000918.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000927.4 [Other Products]
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 UniProt Primary Accession #    P08183 [Other Products]
 UniProt Secondary Accession #    Q12755; Q14812; A8K294; B5AK60 [Other Products]
 UniProt Related Accession #    P08183 [Other Products]
 Molecular Weight    134,032 Da
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 NCBI Official Full Name    multidrug resistance protein 1
 NCBI Official Synonym Full Names    ATP binding cassette subfamily B member 1
 NCBI Official Symbol    ABCB1 [Similar Products]
 NCBI Official Synonym Symbols   
CLCS; MDR1; P-GP; PGY1; ABC20; CD243; GP170
[Similar Products]
 NCBI Protein Information    multidrug resistance protein 1
 UniProt Protein Name    Multidrug resistance protein 1
 UniProt Synonym Protein Names   
ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD_antigen: CD243
 Protein Family    ABC transporter B family
 UniProt Gene Name    ABCB1 [Similar Products]
 UniProt Synonym Gene Names    MDR1; PGY1 [Similar Products]
 UniProt Entry Name    MDR1_HUMAN
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 NCBI Summary for ABCB1    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCB1    ABCB1: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. Interacts with PSMB8.

Protein type: Membrane protein, integral; Cell adhesion; EC 3.6.3.44; Transporter; Transporter, ABC family; Membrane protein, multi-pass; Hydrolase

Chromosomal Location of Human Ortholog: 7q21.12

Cellular Component: cell surface; integral to membrane; membrane; plasma membrane

Molecular Function: ATP binding; ATPase activity, coupled to transmembrane movement of substances; protein binding; transporter activity; xenobiotic-transporting ATPase activity

Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; G2/M transition of mitotic cell cycle; multidrug transport; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; response to drug; transmembrane transport; transport; xenobiotic transport

Disease: Colchicine Resistance; Inflammatory Bowel Disease 13
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 Research Articles on ABCB1    1. The association of antidepressant treatment outcome and six ABCB1 single nucleotide polymorphisms, was studied.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ABCB1 antibodyPathways associated with anti-ABCB1 antibody
 Reference Product  PubMed Publications
 JUN antibody  >1856 publications with ABCB1 and JUN
 HIF1A antibody  >64 publications with ABCB1 and HIF1A
 NR1I2 antibody  >47 publications with ABCB1 and NR1I2
 TP53 antibody  >47 publications with ABCB1 and TP53
 SLC22A1 antibody  >34 publications with ABCB1 and SLC22A1
 SLC22A2 antibody  >16 publications with ABCB1 and SLC22A2
 UBC antibody  >6 publications with ABCB1 and UBC
 MAPK8 antibody  >5 publications with ABCB1 and MAPK8
 PIM1 antibody  >3 publications with ABCB1 and PIM1
 SLC22A3 antibody  >1 publications with ABCB1 and SLC22A3
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Abacavir Transmembrane Transport Pathway antibodies  Abacavir Transmembrane Transport Pathway Diagram
 Abacavir Transport And Metabolism Pathway antibodies  Abacavir Transport And Metabolism Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Codeine And Morphine Metabolism Pathway antibodies  Codeine And Morphine Metabolism Pathway Diagram
 Drug Induction Of Bile Acid Pathway antibodies  Drug Induction Of Bile Acid Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
Diseases associated with anti-ABCB1 antibodyOrgans/Tissues associated with anti-ABCB1 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2456 publications with ABCB1 and Carcinoma
 Breast Neoplasms Antibodies  >1278 publications with ABCB1 and Breast Neoplasms
 Nervous System Diseases Antibodies  >957 publications with ABCB1 and Nervous System Diseases
 Colorectal Neoplasms Antibodies  >516 publications with ABCB1 and Colorectal Neoplasms
 Epilepsy Antibodies  >386 publications with ABCB1 and Epilepsy
 Disease Progression Antibodies  >353 publications with ABCB1 and Disease Progression
 Carcinoma, Non-Small-Cell Lung Antibodies  >340 publications with ABCB1 and Carcinoma, Non-Small-Cell Lung
 Kidney Diseases Antibodies  >332 publications with ABCB1 and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >309 publications with ABCB1 and Carcinoma, Hepatocellular
 Necrosis Antibodies  >284 publications with ABCB1 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2577 publications with ABCB1 and Brain
 Liver Antibodies  >2148 publications with ABCB1 and Liver
 Kidney Antibodies  >1431 publications with ABCB1 and Kidney
 Intestine Antibodies  >1372 publications with ABCB1 and Intestine
 Vascular Antibodies  >719 publications with ABCB1 and Vascular
 Heart Antibodies  >373 publications with ABCB1 and Heart
 Placenta Antibodies  >211 publications with ABCB1 and Placenta
 Muscle Antibodies  >210 publications with ABCB1 and Muscle
 Prostate Antibodies  >205 publications with ABCB1 and Prostate
 Skin Antibodies  >143 publications with ABCB1 and Skin
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