AAH41560.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ABCC4 protein
NCBI Official Synonym Full Names
ATP binding cassette subfamily C member 4
NCBI Protein Information
multidrug resistance-associated protein 4
UniProt Protein Name
Multidrug resistance-associated protein 4
UniProt Synonym Protein Names
ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B
UniProt Synonym Gene Names
NCBI Summary for ABCC4
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
UniProt Comments for ABCC4
ABCC4: a widely-expressed multi-pass membrane protein. An organic anion pump involved in cellular detoxification. Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Chromosomal Location of Human Ortholog: 13q32.1
Cellular Component: basolateral plasma membrane; membrane; plasma membrane; platelet dense granule membrane
Molecular Function: anion transmembrane-transporting ATPase activity; ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
Biological Process: platelet degranulation; prostaglandin secretion; transmembrane transport
Research Articles on ABCC4
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Pathways associated with anti-ABCC4 antibody
Diseases associated with anti-ABCC4 antibody
Organs/Tissues associated with anti-ABCC4 antibody
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