NP_001129473.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Abelson tyrosine-protein kinase 2 isoform e
NCBI Official Synonym Full Names
ABL proto-oncogene 2, non-receptor tyrosine kinase
NCBI Official Synonym Symbols
NCBI Protein Information
Abelson tyrosine-protein kinase 2
UniProt Protein Name
Abelson tyrosine-protein kinase 2
UniProt Synonym Protein Names
Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG
UniProt Synonym Gene Names
NCBI Summary for ABL2
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
UniProt Comments for ABL2
Arg: a cytoplasmic tyrosine kinase of the Abl family. Expressed at the highest levels in mature B cells. Promotes catalase degradation in the oxidative stress response. Localizes to dynamic actin structures and may regulate cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Abl family; EC 2.7.10.2; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of Human Ortholog: 1q25.2
Cellular Component: actin cytoskeleton; cytosol; extrinsic to internal side of plasma membrane
Molecular Function: actin filament binding; actin monomer binding; magnesium ion binding; manganese ion binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein-tyrosine kinase activity; receptor binding
Biological Process: elevation of cytosolic calcium ion concentration; innate immune response; peptidyl-tyrosine phosphorylation; positive regulation of oxidoreductase activity; protein modification process; regulation of autophagy; regulation of cell adhesion; regulation of cell proliferation; regulation of endocytosis; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on ABL2
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Products associated with anti-ABL2 antibody
Pathways associated with anti-ABL2 antibody
Diseases associated with anti-ABL2 antibody
Organs/Tissues associated with anti-ABL2 antibody
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