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anti-ACAT2 antibody :: Mouse ACAT2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS830055
Unit / Price
0.1 mL  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACAT2, Monoclonal Antibody

 Also Known As   

ACAT2 antibody

 Product Synonym Names    Monoclonal ACAT2; Anti-ACAT2; Acetyl-Coenzyme A Acetyltransferase 2; ACAT2; ACAT 2; ACAT-2
 Product Gene Name   

anti-ACAT2 antibody

[Similar Products]
 Matching Pairs    Capture Antibody: ACAT2 Clone #1G6 (MBS831394)
Detection Antibody: ACAT2 Clone #5F7 (MBS830055)
Comments: Suitable pairing for Lateral Flow. Can also be used in ELISA
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    100678
 3D Structure    ModBase 3D Structure for Q9BWD1
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    5F7
 Host    Mouse
 Species Reactivity    Human, Dog, Rat
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 Purity/Purification    ACAT2 antibody was purified by affinity chromatography.
 Form/Format    Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
 Concentration    500 ug-1 mg/ml (lot specific)
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 Biological Significance    Acetyl-Coenzyme A acetyltransferase 2 is an enzyme involved in lipid metabolism. Reported patients with ACAT2 deficiency have shown severe mental retardation and hypotonus. The ACAT2 gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation.
 Immunogen    ACAT2 antibody was raised in mouse using a full length recombinant protein of human ACAT2 (NP_005882) produced in HEK293T cells, as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-ACAT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ACAT2 antibody

   Mouse monoclonal ACAT2 antibody
 Product Categories/Family for anti-ACAT2 antibody    Proteases, Inhibitors, & Enzymes
 Applications Tested/Suitable for anti-ACAT2 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Immunohistochemistry (IHC)

 Application Notes for anti-ACAT2 antibody    FC: 1:100, IF: 1:100, IHC: 1:50
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 Western Blot (WB) of anti-ACAT2 antibody    Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant ACAT2 protein (Right) or empty vector (Left) detected with ACAT2 antibody
anti-ACAT2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ACAT2 antibody    Immunohistochemical analysis of ACAT2 protein in paraffin embedded Human liver tissue using ACAT2 antibody
anti-ACAT2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-ACAT2 antibody    Immunofluorescent staining of COS7 cells transiently transfected with recombinant ACAT2 protein using ACAT2 antibody
anti-ACAT2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ACAT2. It may not necessarily be applicable to this product.
 NCBI GI #    148539872
 NCBI GeneID    39
 NCBI Accession #    NP_005882 [Other Products]
 NCBI GenBank Nucleotide #    NM_005891.2 [Other Products]
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 UniProt Primary Accession #    Q9BWD1 [Other Products]
 UniProt Secondary Accession #    Q16146; Q5TCL7; Q8TDM4; B7Z233; E1P5B1 [Other Products]
 UniProt Related Accession #    Q9BWD1 [Other Products]
 Molecular Weight    44,643 Da
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 NCBI Official Full Name    acetyl-CoA acetyltransferase, cytosolic isoform 1
 NCBI Official Synonym Full Names    acetyl-CoA acetyltransferase 2
 NCBI Official Symbol    ACAT2 [Similar Products]
 NCBI Protein Information    acetyl-CoA acetyltransferase, cytosolic
 UniProt Protein Name    Acetyl-CoA acetyltransferase, cytosolic
 UniProt Synonym Protein Names   
Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase
 Protein Family    Acetyl-CoA acetyltransferase
 UniProt Gene Name    ACAT2 [Similar Products]
 UniProt Synonym Gene Names    ACTL [Similar Products]
 UniProt Entry Name    THIC_HUMAN
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 NCBI Summary for ACAT2    The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
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 UniProt Comments for ACAT2    ACAT2: The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. [provided by RefSeq, Jul 2008]

Protein type: Lipid Metabolism - fatty acid; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Amino Acid Metabolism - lysine degradation; Lipid Metabolism - synthesis and degradation of ketone bodies; Carbohydrate Metabolism - butanoate; EC 2.3.1.9; Carbohydrate Metabolism - pyruvate; Carbohydrate Metabolism - propanoate; Acetyltransferase; Amino Acid Metabolism - tryptophan; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis

Chromosomal Location of Human Ortholog: 6q25.3

Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus

Molecular Function: acetyl-CoA C-acetyltransferase activity

Biological Process: lipid metabolic process

Disease: Acetyl-coa Acetyltransferase-2 Deficiency
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 Research Articles on ACAT2    1. Results show that DLAT and ACAT2 as upstream acetyltransferases of K76 and K294 in 6PGD protein.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to ACAT2 antibody
 Catalog #  Product Name  Catalog #  Product Name
 MBS1271315  ACAT2 cDNA Clone  MBS831072  ACAT2 antibody
 MBS831353  ACAT2 antibody  MBS2072444  HRP-Linked Polyclonal Antibody to Acetyl Coenzyme A Acetyltransferase 2 (ACAT2)
 MBS2072448  Cy3-Linked Polyclonal Antibody to Acetyl Coenzyme A Acetyltransferase 2 (ACAT2)  MBS2533087  Human ACAT2 (Acetyl Coenzyme A Acetyltransferase 2, cytosolic) CLIA Kit
 MBS533485  ACAT2 antibody  MBS2072441  APC-Linked Polyclonal Antibody to Acetyl Coenzyme A Acetyltransferase 2 (ACAT2)
 MBS415414  Anti-ACAT2 Antibody  MBS533616  ACAT2 antibody
Products associated with anti-ACAT2 antibodyPathways associated with anti-ACAT2 antibody
 Reference Product  PubMed Publications
 HMGCS1 antibody  >3 publications with ACAT2 and HMGCS1
 ACACB antibody  >1 publications with ACAT2 and ACACB
 HMGCS2 antibody  >1 publications with ACAT2 and HMGCS2
 Products by Pathway  Pathway Diagram
 Biosynthesis Of Antibiotics Pathway antibodies  Biosynthesis Of Antibiotics Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
Diseases associated with anti-ACAT2 antibodyOrgans/Tissues associated with anti-ACAT2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >28 publications with ACAT2 and Cardiovascular Diseases
 Fatty Liver Antibodies  >18 publications with ACAT2 and Fatty Liver
 Liver Diseases Antibodies  >14 publications with ACAT2 and Liver Diseases
 Liver Neoplasms Antibodies  >7 publications with ACAT2 and Liver Neoplasms
 Disease Models, Animal Antibodies  >7 publications with ACAT2 and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >7 publications with ACAT2 and Carcinoma, Hepatocellular
 Nervous System Diseases Antibodies  >5 publications with ACAT2 and Nervous System Diseases
 Heart Diseases Antibodies  >5 publications with ACAT2 and Heart Diseases
 Brain Diseases Antibodies  >4 publications with ACAT2 and Brain Diseases
 Weight Gain Antibodies  >4 publications with ACAT2 and Weight Gain
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >77 publications with ACAT2 and Liver
 Blood Antibodies  >43 publications with ACAT2 and Blood
 Intestine Antibodies  >38 publications with ACAT2 and Intestine
 Vascular Antibodies  >7 publications with ACAT2 and Vascular
 Heart Antibodies  >7 publications with ACAT2 and Heart
 Kidney Antibodies  >4 publications with ACAT2 and Kidney
 Brain Antibodies  >4 publications with ACAT2 and Brain
 Connective Tissue Antibodies  >3 publications with ACAT2 and Connective Tissue
 Bone Antibodies  >3 publications with ACAT2 and Bone
 Adrenal Gland Antibodies  >3 publications with ACAT2 and Adrenal Gland
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