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anti-ACE antibody :: Mouse ACE Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS531334
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $655 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACE, Monoclonal Antibody

 Also Known As   

ACE antibody

 Product Synonym Names    Monoclonal ACE; Anti-ACE; Angiotensin Converting Enzyme; CD143
 Product Gene Name   

anti-ACE antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    106180
 3D Structure    ModBase 3D Structure for P12821
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    9B9
 Host    Mouse
 Species Reactivity    Cat, Hamster, Monkey, Rat
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 Specificity    Human
 Form/Format    PBS, pH 7.4, with 150mM NaCl and 0.05% NaN3.
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 Biological Significance    Angiotensin I-converting enzyme an exopeptidase, is a circulating enzyme that participates in the body's renin-angiotensin system (RAS), which mediates extracellular volume (i.e. that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. It is secreted by pulmonary and renal endothelial cells and catalyzes the conversion of decapeptide angiotensin I to octapeptide angiotensin II.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
 Immunogen    ACE antibody was raised in mouse using ACE from human lung as the immunogen.
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 Preparation and Storage    Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles
 Other Notes    Small volumes of anti-ACE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACE antibody

   Mouse monoclonal ACE antibody
 Product Categories/Family for anti-ACE antibody    Proteases, Inhibitors, & Enzymes
 Applications Tested/Suitable for anti-ACE antibody   

ELISA (EIA), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin, Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-ACE antibody    ELISA: 1:1,000
ICC: 1:100
IHC-F: 1:1,000
IP: 1:1,000-1:10,000
WB: 1:100
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 Immunohistochemistry (IHC) of anti-ACE antibody    Mouse anti-ACE antibody staining of rat heart myocardium three weeks after a myocardial infarction
anti-ACE antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ACE. It may not necessarily be applicable to this product.
 NCBI GI #    113045
 NCBI GeneID    1636
 NCBI Accession #    P12821.1 [Other Products]
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 UniProt Primary Accession #    P12821 [Other Products]
 UniProt Secondary Accession #    P22966; Q53YX9; Q59GY8; Q7M4L4; B0LPF0; B4DXI3; E7EU16 [Other Products]
 UniProt Related Accession #    P12821 [Other Products]
 Molecular Weight    78,694 Da
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 NCBI Official Full Name    Angiotensin-converting enzyme
 NCBI Official Synonym Full Names    angiotensin I converting enzyme
 NCBI Official Symbol    ACE [Similar Products]
 NCBI Official Synonym Symbols   
DCP; ICH; ACE1; DCP1; CD143; MVCD3
[Similar Products]
 NCBI Protein Information    angiotensin-converting enzyme
 UniProt Protein Name    Angiotensin-converting enzyme
 UniProt Synonym Protein Names   
Dipeptidyl carboxypeptidase I; Kininase II; CD_antigen: CD143
 Protein Family    Acetamidase
 UniProt Gene Name    ACE [Similar Products]
 UniProt Synonym Gene Names    DCP; DCP1; ACE [Similar Products]
 UniProt Entry Name    ACE_HUMAN
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 NCBI Summary for ACE    This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
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 UniProt Comments for ACE    ACE: Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. Genetic variations in ACE may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Defects in ACE are a cause of renal tubular dysgenesis (RTD). RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Genetic variations in ACE are associated with susceptibility to microvascular complications of diabetes type 3 (MVCD3). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new- onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Defects in ACE are a cause of susceptibility to intracerebral hemorrhage (ICH). A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. Belongs to the peptidase M2 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Membrane protein, integral; EC 3.4.15.1

Chromosomal Location of Human Ortholog: 17q23.3

Cellular Component: extracellular space; lysosome; integral to membrane; plasma membrane; extracellular region; endosome; external side of plasma membrane

Molecular Function: tripeptidyl-peptidase activity; peptidyl-dipeptidase activity; carboxypeptidase activity; zinc ion binding; metallopeptidase activity; mitogen-activated protein kinase kinase binding; drug binding; actin binding; protein binding; bradykinin receptor binding; endopeptidase activity; exopeptidase activity; mitogen-activated protein kinase binding; chloride ion binding

Biological Process: mononuclear cell proliferation; regulation of vasodilation; angiotensin mediated regulation of renal output; neutrophil mediated immunity; regulation of angiotensin metabolic process; arachidonic acid secretion; proteolysis; angiotensin maturation; regulation of systemic arterial blood pressure by renin-angiotensin; antigen processing and presentation of peptide antigen via MHC class I; regulation of smooth muscle cell migration; cellular protein metabolic process; heart contraction; beta-amyloid metabolic process; regulation of blood pressure; peptide catabolic process; regulation of vasoconstriction; angiotensin catabolic process in blood; spermatogenesis; blood vessel remodeling; hormone catabolic process; kidney development

Disease: Renal Tubular Dysgenesis; Microvascular Complications Of Diabetes, Susceptibility To, 3; Alzheimer Disease; Hemorrhage, Intracerebral, Susceptibility To
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 Research Articles on ACE    1. Significant SNPs in ACE and MMP3 also showed association with Alzheimer's disease (AD) risk.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACE antibodyPathways associated with anti-ACE antibody
 Reference Product  PubMed Publications
 ACE2 antibody  >531 publications with ACE and ACE2
 AGT antibody  >472 publications with ACE and AGT
 BDKRB2 antibody  >335 publications with ACE and BDKRB2
 NOS3 antibody  >164 publications with ACE and NOS3
 REN antibody  >152 publications with ACE and REN
 TFPI antibody  >10 publications with ACE and TFPI
 ATP6AP2 antibody  >10 publications with ACE and ATP6AP2
 MDK antibody  >3 publications with ACE and MDK
 KNG1 antibody  >1 publications with ACE and KNG1
 SOD3 antibody  >1 publications with ACE and SOD3
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
Diseases associated with anti-ACE antibodyOrgans/Tissues associated with anti-ACE antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >14011 publications with ACE and Cardiovascular Diseases
 Hypertension Antibodies  >9084 publications with ACE and Hypertension
 Heart Failure Antibodies  >4713 publications with ACE and Heart Failure
 Kidney Diseases Antibodies  >3540 publications with ACE and Kidney Diseases
 Myocardial Infarction Antibodies  >2608 publications with ACE and Myocardial Infarction
 Coronary Disease Antibodies  >2234 publications with ACE and Coronary Disease
 Stroke Antibodies  >1451 publications with ACE and Stroke
 Renal Insufficiency Antibodies  >1370 publications with ACE and Renal Insufficiency
 Respiratory Tract Diseases Antibodies  >1325 publications with ACE and Respiratory Tract Diseases
 Coronary Artery Disease Antibodies  >1263 publications with ACE and Coronary Artery Disease
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12481 publications with ACE and Blood
 Heart Antibodies  >8468 publications with ACE and Heart
 Vascular Antibodies  >4666 publications with ACE and Vascular
 Kidney Antibodies  >4339 publications with ACE and Kidney
 Muscle Antibodies  >2231 publications with ACE and Muscle
 Lung Antibodies  >1622 publications with ACE and Lung
 Brain Antibodies  >1361 publications with ACE and Brain
 Intestine Antibodies  >283 publications with ACE and Intestine
 Eye Antibodies  >247 publications with ACE and Eye
 Testis Antibodies  >228 publications with ACE and Testis
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