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anti-ACP2 antibody :: Mouse anti-Human ACP2 / Acid Phosphatase 2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS246116
Unit / Price
0.05 mg  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACP2 / Acid Phosphatase 2, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone M1-4A12] (IgG2b,l) to Human ACP2 / Acid Phosphatase 2

 Product Synonym Names    Anti-ACP2 / Acid Phosphatase 2 Antibody (clone M1-4A12) IHC-plus; ACP2; Acid Phosphatase 2; Acid phosphatase 2; lysosomal; LAP; Lysosomal acid phosphatase; Human ACP2; Acid Phosphatase 2
 Product Gene Name   

anti-ACP2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 200950
 3D Structure    ModBase 3D Structure for P11117
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 Clonality    Monoclonal
 Isotype    IgG2b,l
 Clone Number    M1-4A12
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Human ACP2
 Purity/Purification    Protein A Purified
 Form/Format    PBS, pH 7.2
 Concentration    0.41 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    ACP2 (AAH03160, 1 a.a. ~ 424 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
 Immunogen    ACP2 / Acid Phosphatase 2 antibody was raised against aCP2 (AAH03160, 1 a.a. ~ 424 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-ACP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ACP2 antibody

   Lysosomal acid phosphatase is comprised of two subunits, alpha and beta, and is chemically and genetically distinct from red cell acid phosphatase. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Acid phosphatase deficiency is caused by mutations in the ACP2 (beta subunit) and ACP3 (alpha subunit) genes.
 Applications Tested/Suitable for anti-ACP2 antibody   

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ACP2 antibody    ELISA, IF (10 ug/ml), IHC-P (10 ug/ml), WB
Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. RNAi Knockdown: Antibody validated. Western Blot: Transfected lysate, Recombinant protein.
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 Immunohistochemistry (IHC) of anti-ACP2 antibody    Anti-ACP2 / Acid Phosphatase 2 antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-ACP2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-ACP2 antibody    Immunofluorescence of monoclonal antibody to ACP2 on HeLa cell. [antibody concentration 10 ug/ml]
anti-ACP2 antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-ACP2 antibody    Western blot of ACP2 expression in transfected 293T cell line by ACP2 monoclonal antibody (M01), clone M1-4A12.
anti-ACP2 antibody Western Blot (WB) (WB) image
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 RNA interference of anti-ACP2 antibody    Western blot of ACP2 over-expressed 293 cell line, cotransfected with ACP2 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with ACP2 monoclonal antibody, clone M1-4A12. GAPDH (36.1 kD) used as specificity and loading control.
anti-ACP2 antibody RNA interference image
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NCBI/Uniprot data below describe general gene information for ACP2. It may not necessarily be applicable to this product.
 NCBI GI #    4557010
 NCBI GeneID    53
 NCBI Accession #    NP_001601.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001610.3 [Other Products]
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 UniProt Primary Accession #    P11117 [Other Products]
 UniProt Secondary Accession #    Q561W5; Q9BTU7; E9PCI1 [Other Products]
 UniProt Related Accession #    P11117 [Other Products]
 Molecular Weight    18,417 Da
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 NCBI Official Full Name    lysosomal acid phosphatase isoform 1
 NCBI Official Synonym Full Names    acid phosphatase 2, lysosomal
 NCBI Official Symbol    ACP2 [Similar Products]
 NCBI Official Synonym Symbols   
LAP
[Similar Products]
 NCBI Protein Information    lysosomal acid phosphatase
 UniProt Protein Name    Lysosomal acid phosphatase
 Protein Family    Cysteine proteinase
 UniProt Gene Name    ACP2 [Similar Products]
 UniProt Synonym Gene Names    LAP [Similar Products]
 UniProt Entry Name    PPAL_HUMAN
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 NCBI Summary for ACP2    This gene encodes the beta subunit of lysosomal acid phosphatase (LAP). LAP is chemically and genetically distinct from red cell acid phosphatase. The encoded protein belongs to a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. LAP-deficiencies in mice cause multiple defects including bone structure alterations, lysosomal storage defects in the kidneys and central nervous system, and an increased tendency towards seizures. An enzymatically-inactive allele of LAP in mice exhibited a more severe phenotype than the null allele, and defects included cerebellum abnormalities, growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
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 UniProt Comments for ACP2    ACP2: Defects in ACP2 are a cause of acid phosphatase deficiency (ACPHD). The clinical features are intermittent vomiting, hypotonia, lethargy, opisthotonos, terminal bleeding, and death in early infancy. Lysosomal acid phosphatase is deficient in cultured fibroblasts and multiple tissues. Belongs to the histidine acid phosphatase family.

Protein type: EC 3.1.3.2; Cofactor and Vitamin Metabolism - riboflavin; Motility/polarity/chemotaxis; Phosphatase (non-protein); Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p11.2|11p12-p11

Cellular Component: lysosomal lumen; membrane; lysosome; lysosomal membrane; integral to membrane

Molecular Function: acid phosphatase activity

Biological Process: dephosphorylation; lysosome organization and biogenesis; skeletal development

Disease: Acid Phosphatase Deficiency
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 Research Articles on ACP2    1. An enzymatically inactive allele of mouse Acp2 causes cerebellum abnormalities, growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACP2 antibodyPathways associated with anti-ACP2 antibody
 Reference Product  PubMed Publications
 ACP1 antibody  >23 publications with ACP2 and ACP1
 LDHA antibody  >6 publications with ACP2 and LDHA
 CTSD antibody  >1 publications with ACP2 and CTSD
 ACP5 antibody  >1 publications with ACP2 and ACP5
 Products by Pathway  Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Riboflavin Metabolism Pathway antibodies  Riboflavin Metabolism Pathway Diagram
 Riboflavin Metabolism Pathway antibodies  Riboflavin Metabolism Pathway Diagram
Diseases associated with anti-ACP2 antibodyOrgans/Tissues associated with anti-ACP2 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with ACP2 and Nervous System Diseases
 Brain Diseases Antibodies  >2 publications with ACP2 and Brain Diseases
 Chromosome Aberrations Antibodies  >1 publications with ACP2 and Chromosome Aberrations
 Aneuploidy Antibodies  >1 publications with ACP2 and Aneuploidy
 Adenocarcinoma Antibodies  >1 publications with ACP2 and Adenocarcinoma
 Liver Neoplasms Antibodies  >1 publications with ACP2 and Liver Neoplasms
 Liver Neoplasms, Experimental Antibodies  >1 publications with ACP2 and Liver Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >1 publications with ACP2 and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with ACP2 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >9 publications with ACP2 and Liver
 Blood Antibodies  >8 publications with ACP2 and Blood
 Brain Antibodies  >6 publications with ACP2 and Brain
 Spleen Antibodies  >2 publications with ACP2 and Spleen
 Bone Marrow Antibodies  >2 publications with ACP2 and Bone Marrow
 Bone Antibodies  >2 publications with ACP2 and Bone
 Muscle Antibodies  >2 publications with ACP2 and Muscle
 Skin Antibodies  >2 publications with ACP2 and Skin
 Placenta Antibodies  >1 publications with ACP2 and Placenta
 Prostate Antibodies  >1 publications with ACP2 and Prostate
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