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anti-ACSS2 antibody :: Mouse anti-Human ACSS2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS831887
Western Blot (WB)
Unit / Price
0.1 mL  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACSS2, Monoclonal Antibody

 Also Known As   

ACSS2 antibody

 Product Synonym Names    Monoclonal ACSS2; Anti-ACSS2; Acyl-CoA synthetase short-chain family member 2; ACS; ACSA; Acetate CoA ligase; Acyl-activating enzyme; ACAS2; Acetate thiokinase; Acetate-CoA ligase; Acetyl-CoA synthetase; ACSS2; ACSS 2; ACSS-2
 Product Gene Name   

anti-ACSS2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605832
 3D Structure    ModBase 3D Structure for Q9NR19
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    3A8
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    ACSS2 antibody was purified by affinity chromatography.
 Form/Format    Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
 Concentration    500 ug-1 mg/ml (lot specific)
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 Biological Significance    ACSS2 is a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP.
 Immunogen    ACSS2 antibody was raised in mouse using a full length recombinant protein of human ACSS2 (NP_061147) produced in HEK293T cells, as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-ACSS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACSS2 antibody

   Mouse monoclonal ACSS2 antibody
 Product Categories/Family for anti-ACSS2 antibody    Proteases, Inhibitors, & Enzymes
 Applications Tested/Suitable for anti-ACSS2 antibody   

Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-ACSS2 antibody    IHC: 1:150
WB: 1:2000
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 Western Blot (WB) of anti-ACSS2 antibody    Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant ACSS2 protein (Right) or empty vector (Left) detected with ACSS2 antibody
anti-ACSS2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ACSS2. It may not necessarily be applicable to this product.
 NCBI GI #    8923896
 NCBI GeneID    55902
 NCBI Accession #    NP_061147 [Other Products]
 NCBI GenBank Nucleotide #    NM_018677.3 [Other Products]
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 UniProt Primary Accession #    Q9NR19 [Other Products]
 UniProt Secondary Accession #    Q5QPH2; Q5QPH3; Q8N238; Q96EL0; Q9NQP7; Q9UJ15; A6NE90 [Other Products]
 UniProt Related Accession #    Q9NR19 [Other Products]
 Molecular Weight    80,087 Da
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 NCBI Official Full Name    acetyl-coenzyme A synthetase, cytoplasmic isoform 1
 NCBI Official Synonym Full Names    acyl-CoA synthetase short-chain family member 2
 NCBI Official Symbol    ACSS2 [Similar Products]
 NCBI Official Synonym Symbols   
ACS; ACSA; ACAS2; ACECS; dJ1161H23.1
[Similar Products]
 NCBI Protein Information    acetyl-coenzyme A synthetase, cytoplasmic
 UniProt Protein Name    Acetyl-coenzyme A synthetase, cytoplasmic
 UniProt Synonym Protein Names   
Acetate--CoA ligase; Acetyl-CoA synthetase; ACS; AceCS; Acyl-CoA synthetase short-chain family member 2; Acyl-activating enzyme
 Protein Family    Acetyl-coenzyme A synthetase
 UniProt Gene Name    ACSS2 [Similar Products]
 UniProt Synonym Gene Names    ACAS2; ACS; AceCS [Similar Products]
 UniProt Entry Name    ACSA_HUMAN
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 NCBI Summary for ACSS2    This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of cholesterol and unsaturated fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
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 UniProt Comments for ACSS2    ACSS2: Activates acetate so that it can be used for lipid synthesis or for energy generation. Monomer. Belongs to the ATP-dependent AMP-binding enzyme family.

Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Ligase; EC 6.2.1.1; Carbohydrate Metabolism - pyruvate

Chromosomal Location of Human Ortholog: 20q11.22

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; cytoplasm; cytosol

Molecular Function: acetate-CoA ligase activity; ATP binding; AMP binding

Biological Process: acetyl-CoA biosynthetic process from acetate; xenobiotic metabolic process; lipid biosynthetic process; propionate biosynthetic process; ethanol oxidation; acetate biosynthetic process
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 Research Articles on ACSS2    1. Study revealed that the activity of acetyl-CoA synthetase 2 (ACSS2) contributes to cancer cell growth under low-oxygen and lipid-depleted conditions.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACSS2 antibodyPathways associated with anti-ACSS2 antibody
 Reference Product  PubMed Publications
 ACACA antibody  >6 publications with ACSS2 and ACACA
 ACAT2 antibody  >1 publications with ACSS2 and ACAT2
 ALDH1A1 antibody  >1 publications with ACSS2 and ALDH1A1
 SIRT1 antibody  >1 publications with ACSS2 and SIRT1
 ACACB antibody  >1 publications with ACSS2 and ACACB
 Products by Pathway  Pathway Diagram
 Amino Acid Conjugation Of Benzoic Acid Pathway antibodies  Amino Acid Conjugation Of Benzoic Acid Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Biosynthesis Of Antibiotics Pathway antibodies  Biosynthesis Of Antibiotics Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Ethanol Oxidation Pathway antibodies  Ethanol Oxidation Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fatty Acid Biosynthesis Pathway antibodies  Fatty Acid Biosynthesis Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
Diseases associated with anti-ACSS2 antibodyOrgans/Tissues associated with anti-ACSS2 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >3 publications with ACSS2 and Breast Neoplasms
 Fatty Liver Antibodies  >3 publications with ACSS2 and Fatty Liver
 Carcinoma, Hepatocellular Antibodies  >2 publications with ACSS2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >2 publications with ACSS2 and Liver Neoplasms
 Liver Diseases Antibodies  >2 publications with ACSS2 and Liver Diseases
 Hyperglycemia Antibodies  >2 publications with ACSS2 and Hyperglycemia
 Atherosclerosis Antibodies  >2 publications with ACSS2 and Atherosclerosis
 Glucose Intolerance Antibodies  >2 publications with ACSS2 and Glucose Intolerance
 Inflammation Antibodies  >2 publications with ACSS2 and Inflammation
 Disease Models, Animal Antibodies  >1 publications with ACSS2 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with ACSS2 and Blood
 Liver Antibodies  >7 publications with ACSS2 and Liver
 Connective Tissue Antibodies  >3 publications with ACSS2 and Connective Tissue
 Heart Antibodies  >2 publications with ACSS2 and Heart
 Embryonic Tissue Antibodies  >1 publications with ACSS2 and Embryonic Tissue
 Mammary Gland Antibodies  >1 publications with ACSS2 and Mammary Gland
 Kidney Antibodies  >1 publications with ACSS2 and Kidney
 Brain Antibodies  >1 publications with ACSS2 and Brain
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