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anti-ACTA2 antibody :: Mouse anti-Human ACTA2 / Smooth Muscle Actin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245514
Unit / Price
0.05 mg  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACTA2 / Smooth Muscle Actin, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone 1D11-2B9] (IgG1,k) to Human ACTA2 / Smooth Muscle Actin

 Product Synonym Names    Anti-ACTA2 / Smooth Muscle Actin Antibody (clone 1D11-2B9) IHC-plus; ACTVS; Alpha-actin-2; Alpha-cardiac actin; AAT6; Actin; aortic smooth muscle; ACTSA; Smooth Muscle Actin; MYMY5; Human ACTA2; Smooth Muscle Actin
 Product Gene Name   

anti-ACTA2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 614042
 3D Structure    ModBase 3D Structure for P62736
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    1D11-2B9
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Human ACTA2
 Purity/Purification    Protein A Purified
 Form/Format    PBS, pH 7.2
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    ACTA2 (AAH17554, 1 a.a. ~ 378 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
 Immunogen    ACTA2 / Smooth Muscle Actin antibody was raised against aCTA2 (AAH17554, 1 a.a. ~ 378 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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 Preparation and Storage    Store at -20 degree C or lower. Aliquot to avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-ACTA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ACTA2 antibody

   Actin alpha 2, the human aortic smooth muscle actin gene, is one of six different actin isoforms which have been identified. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.
 Applications Tested/Suitable for anti-ACTA2 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ACTA2 antibody    ELISA, IHC-P (5 ug/ml), WB (1:500 - 1:1000)
Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Sandwich ELISA: Recombinant protein. Western Blot: Recombinant protein.
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 Immunohistochemistry (IHC) of anti-ACTA2 antibody    Anti-ACTA2 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-ACTA2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ACTA2 antibody    Anti-ACTA2 antibody IHC of human vessels. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-ACTA2 antibody Immunohistochemistry (IHC) (IHC) image
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 ELISA (EIA) of anti-ACTA2 antibody    Detection limit for recombinant GST tagged ACTA2 is approximately 0.3 ng/ml as a capture antibody.
anti-ACTA2 antibody ELISA (EIA) image
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NCBI/Uniprot data below describe general gene information for ACTA2. It may not necessarily be applicable to this product.
 NCBI GI #    4501883
 NCBI GeneID    59
 NCBI Accession #    NP_001604.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001613.2 [Other Products]
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 UniProt Primary Accession #    P62736 [Other Products]
 UniProt Secondary Accession #    P03996; P04108; Q6FI19; B2R8A4 [Other Products]
 UniProt Related Accession #    P62736 [Other Products]
 Molecular Weight    42,009 Da
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 NCBI Official Full Name    actin, aortic smooth muscle
 NCBI Official Synonym Full Names    actin, alpha 2, smooth muscle, aorta
 NCBI Official Symbol    ACTA2 [Similar Products]
 NCBI Official Synonym Symbols   
AAT6; ACTSA; MYMY5
[Similar Products]
 NCBI Protein Information    actin, aortic smooth muscle; alpha-cardiac actin; cell growth-inhibiting gene 46 protein
 UniProt Protein Name    Actin, aortic smooth muscle
 UniProt Synonym Protein Names   
Alpha-actin-2; Cell growth-inhibiting gene 46 protein
 Protein Family    Actin
 UniProt Gene Name    ACTA2 [Similar Products]
 UniProt Synonym Gene Names    ACTSA; ACTVS [Similar Products]
 UniProt Entry Name    ACTA_HUMAN
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 NCBI Summary for ACTA2    The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
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 UniProt Comments for ACTA2    ACTA2: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the actin family.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal; Contractile

Chromosomal Location of Human Ortholog: 10q23.3

Cellular Component: extracellular space; smooth muscle contractile fiber; protein complex; cytoplasm; cytosol; actin cytoskeleton

Molecular Function: protein kinase binding; ATP binding

Biological Process: muscle contraction; regulation of blood pressure; response to virus; vascular smooth muscle contraction

Disease: Moyamoya Disease 5; Multisystemic Smooth Muscle Dysfunction Syndrome; Aortic Aneurysm, Familial Thoracic 6
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 Research Articles on ACTA2    1. Sphingosylphosphorylcholine stimulates alpha-SMA protein expression and human lung fibroblast mediated collagen gel contraction via S1P2 receptor.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACTA2 antibodyPathways associated with anti-ACTA2 antibody
 Reference Product  PubMed Publications
 TGFB1 antibody  >155 publications with ACTA2 and TGFB1
 MYH11 antibody  >28 publications with ACTA2 and MYH11
 TAGLN antibody  >10 publications with ACTA2 and TAGLN
 CFL1 antibody  >1 publications with ACTA2 and CFL1
 UBC antibody  >1 publications with ACTA2 and UBC
 ACTN2 antibody  >1 publications with ACTA2 and ACTN2
 Products by Pathway  Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Smooth Muscle Contraction Pathway antibodies  Smooth Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
Diseases associated with anti-ACTA2 antibodyOrgans/Tissues associated with anti-ACTA2 antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >243 publications with ACTA2 and Fibrosis
 Cardiovascular Diseases Antibodies  >102 publications with ACTA2 and Cardiovascular Diseases
 Liver Diseases Antibodies  >73 publications with ACTA2 and Liver Diseases
 Inflammation Antibodies  >73 publications with ACTA2 and Inflammation
 Disease Models, Animal Antibodies  >64 publications with ACTA2 and Disease Models, Animal
 Liver Cirrhosis Antibodies  >53 publications with ACTA2 and Liver Cirrhosis
 Kidney Diseases Antibodies  >43 publications with ACTA2 and Kidney Diseases
 Breast Neoplasms Antibodies  >34 publications with ACTA2 and Breast Neoplasms
 Aortic Aneurysm, Thoracic Antibodies  >30 publications with ACTA2 and Aortic Aneurysm, Thoracic
 Heart Diseases Antibodies  >27 publications with ACTA2 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >615 publications with ACTA2 and Muscle
 Vascular Antibodies  >188 publications with ACTA2 and Vascular
 Blood Antibodies  >133 publications with ACTA2 and Blood
 Lung Antibodies  >110 publications with ACTA2 and Lung
 Eye Antibodies  >106 publications with ACTA2 and Eye
 Connective Tissue Antibodies  >96 publications with ACTA2 and Connective Tissue
 Liver Antibodies  >93 publications with ACTA2 and Liver
 Kidney Antibodies  >76 publications with ACTA2 and Kidney
 Skin Antibodies  >67 publications with ACTA2 and Skin
 Bone Antibodies  >53 publications with ACTA2 and Bone
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