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anti-POMC antibody :: Mouse ACTH Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS438106
Testing Data
Unit / Price
0.02 mg (With BSA & Azide at 0.2mg/ml)  /  $190 +1 FREE 8GB USB
0.1 mg (With BSA & Azide at 0.2mg/ml)  /  $300 +1 FREE 8GB USB
0.1 mg (Without BSA & Azide at 1mg/ml)  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACTH (POMC), Monoclonal Antibody

★Popular Item★
 Also Known As   

ACTH

 Product Synonym Names    Adrenocorticotropin; alpha or beta or gamma Melanocyte Stimulating Hormone (MSH) or Melanotropin; beta-Endorphin; beta or gamma Lipotropin (LPH); CLIP; Met Enkephalin; POC; POMC
 Product Gene Name   

anti-POMC antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609734
 3D Structure    ModBase 3D Structure for P01189
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 Clonality    Monoclonal
 Isotype    IgG1, kappa
 Clone Number    AH26
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat. Expected to show a broad species reactivity.
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 Specificity    ACTH (same as Corticotropin) is a 39 amino acid active peptide produced by the anterior pituitary. This MAb is specific to Synacthen (aa1-24 of ACTH); does not react with CLIP (aa17-39 of ACTH). POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.
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 Localization    Cytoplasmic
 Positive Control    Normal pituitary gland or pituitary tumor
 Human Chromosomal Location    2p23.3
 Immunogen    Synthetic peptide corresponding to aa1-24 of human ACTH
 Quantity and Buffer    0.5 ml at 200ug/ml with BSA and azide
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 Preparation and Storage    Store at 2 to 8 degree C. Antibody is stable for 24 months.
 Other Notes    Small volumes of anti-POMC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-POMC antibody   

ELISA (EIA), Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)

 Application Notes for anti-POMC antibody    ELISA (For coating, order Ab without BSA); Flow Cytometry (0.5-1ug/million cells); Immunofluorescence (1-2ug/ml); Western Blotting (0.5-1ug/ml); Immunoprecipitation (1-2ug/500ug protein lysate); Immunohistology (Frozen & Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT) (No special pretreatment is required for staining of formalin-fixed tissues) Optimal dilution for a specific application should be determined.
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 Testing Data of anti-POMC antibody    Formalin-paraffin human pituitary gland stained with ACTH Ab (AH26).
anti-POMC antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for POMC. It may not necessarily be applicable to this product.
 NCBI GI #    4505949
 NCBI GeneID    5443
 NCBI Accession #    NP_000930.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000939.2 [Other Products]
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 UniProt Primary Accession #    P01189 [Other Products]
 UniProt Secondary Accession #    P78442; Q53T23; Q9UD39; Q9UD40 [Other Products]
 UniProt Related Accession #    P01189 [Other Products]
 Molecular Weight    ACTH is ~5kDa; the POMC precursor is ~30kDa.
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 NCBI Official Full Name    pro-opiomelanocortin preproprotein
 NCBI Official Synonym Full Names    proopiomelanocortin
 NCBI Official Symbol    POMC [Similar Products]
 NCBI Official Synonym Symbols   
LPH; MSH; NPP; POC; ACTH; CLIP
[Similar Products]
 NCBI Protein Information    pro-opiomelanocortin; beta-LPH; beta-MSH; alpha-MSH; gamma-LPH; gamma-MSH; beta-endorphin; met-enkephalin; lipotropin beta; lipotropin gamma; melanotropin beta; melanotropin alpha; melanotropin gamma; pro-ACTH-endorphin; adrenocorticotropin; corticotropin-lipotropin; adrenocorticotropic hormone; opiomelanocortin prepropeptide; proopiomelanocortin preproprotein; beta-melanocyte-stimulating hormone; alpha-melanocyte-stimulating hormone; corticotropin-like intermediary peptide
 UniProt Protein Name    Pro-opiomelanocortin
 UniProt Synonym Protein Names   
Corticotropin-lipotropinCleaved into the following 11 chains:NPP; Melanotropin gammaAlternative name(s):Gamma-MSH
 Protein Family    Corticotropin
 UniProt Gene Name    POMC [Similar Products]
 UniProt Synonym Gene Names    POMC; ACTH; CLIP [Similar Products]
 UniProt Entry Name    COLI_HUMAN
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 NCBI Summary for POMC    This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for POMC    POMC: ACTH stimulates the adrenal glands to release cortisol. Defects in POMC may be associated with susceptibility to obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD). Affected individuals present early-onset obesity, adrenal insufficiency and red hair. Belongs to the POMC family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: peroxisomal matrix; extracellular space; cytoplasm; extracellular region; peroxisome; secretory granule

Molecular Function: type 3 melanocortin receptor binding; G-protein-coupled receptor binding; type 4 melanocortin receptor binding; hormone activity; receptor binding

Biological Process: generation of precursor metabolites and energy; cellular protein metabolic process; cell-cell signaling; neuropeptide signaling pathway; regulation of blood pressure; peptide hormone processing; regulation of appetite; positive regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor production; glucose homeostasis; signal transduction; cellular pigmentation

Disease: Obesity; Proopiomelanocortin Deficiency
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Product References and Citations for anti-POMC antibody

   1. Hsu DW et. al. American Journal of Pathology, 1991, 138(4):897-909.
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 Research Articles on POMC    1. Leukocyte methylation levels reflect a putative epigenetic regulation of NPY and POMC, which might be implicated in weight regain in obese men.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-POMC antibodyPathways associated with anti-POMC antibody
 Reference Product  PubMed Publications
 CRH antibody  >2199 publications with POMC and CRH
 NPY antibody  >769 publications with POMC and NPY
 MC4R antibody  >339 publications with POMC and MC4R
 MC1R antibody  >225 publications with POMC and MC1R
 CYP17A1 antibody  >199 publications with POMC and CYP17A1
 MC3R antibody  >149 publications with POMC and MC3R
 MC2R antibody  >123 publications with POMC and MC2R
 MC5R antibody  >89 publications with POMC and MC5R
 OPRM1 antibody  >15 publications with POMC and OPRM1
 GIPR antibody  >4 publications with POMC and GIPR
 Products by Pathway  Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Cytochrome P450 - Arranged By Substrate Type Pathway antibodies  Cytochrome P450 - Arranged By Substrate Type Pathway Diagram
 Endogenous Sterols Pathway antibodies  Endogenous Sterols Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
Diseases associated with anti-POMC antibodyOrgans/Tissues associated with anti-POMC antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >4192 publications with POMC and Immune System Diseases
 Cushing Syndrome Antibodies  >2883 publications with POMC and Cushing Syndrome
 Mental Disorders Antibodies  >2651 publications with POMC and Mental Disorders
 Obesity Antibodies  >1684 publications with POMC and Obesity
 Infection Antibodies  >1007 publications with POMC and Infection
 Kidney Diseases Antibodies  >997 publications with POMC and Kidney Diseases
 Gastrointestinal Diseases Antibodies  >942 publications with POMC and Gastrointestinal Diseases
 Diabetes Mellitus Antibodies  >845 publications with POMC and Diabetes Mellitus
 Hemorrhage Antibodies  >669 publications with POMC and Hemorrhage
 Necrosis Antibodies  >667 publications with POMC and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >18347 publications with POMC and Brain
 Pituitary Gland Antibodies  >8993 publications with POMC and Pituitary Gland
 Lung Antibodies  >985 publications with POMC and Lung
 Eye Antibodies  >613 publications with POMC and Eye
 Testis Antibodies  >553 publications with POMC and Testis
 Intestine Antibodies  >434 publications with POMC and Intestine
 Embryonic Tissue Antibodies  >390 publications with POMC and Embryonic Tissue
 Placenta Antibodies  >367 publications with POMC and Placenta
 Uterus Antibodies  >239 publications with POMC and Uterus
 Uncharacterized Tissue Antibodies  >2 publications with POMC and Uncharacterized Tissue
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