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anti-ACVR2B antibody :: Rabbit anti-Mouse ACVR2B Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2544505 anti-ACVR2B antibody
Unit / Price
0.06 mL  /  $215 +1 FREE 8GB USB
0.12 mL  /  $330 +1 FREE 8GB USB
0.2 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACVR2B, Monoclonal Antibody

 Also Known As   

Rabbit anti MouseACVR2B Monoclonal Antibody

 Product Gene Name   

anti-ACVR2B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    X77533 mRNA
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 Clonality    Monoclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Mouse
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 Immunogen    Recombinant Mouse ACVR2B Protein
 Buffer    0.2 mum filtered solution in PBS
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 Preparation and Storage    This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-ACVR2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ACVR2B antibody

   ACVR2A and ACVR2B are two activin type II receptors. ACVR2B is integral to the activin and myostatin signaling pathway. Ligands such as activin and myostatin bind to ACVR2A and ACVR2B. Myostatin, a negative regulator of skeletal muscle growth, is regarded as a potential therapeutic target and binds to ACVR2B effectively, and to a lesser extent, to ACVR2A. The structure of human ACVR2B kinase domain in complex with adenine establishes the conserved bilobal architecture consistent with all other catalytic kinase domains. Haplotype structure at the ACVR2B and follistatin loci may contribute to interindividual variation in skeletal muscle mass and strength. Defects in ACVR2B are a cause of left-right axis malformations.
 Applications Tested/Suitable for anti-ACVR2B antibody   

ELISA (EIA)

 Application Notes for anti-ACVR2B antibody    ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Mouse ACVR2B.
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NCBI/Uniprot data below describe general gene information for ACVR2B. It may not necessarily be applicable to this product.
 NCBI GI #    116734708
 NCBI GeneID    93
 NCBI GenBank Nucleotide #    NM_001106.3 [Other Products]
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 UniProt Secondary Accession #    Q4VAV0 [Other Products]
 UniProt Related Accession #    Q13705 [Other Products]
 Molecular Weight    – Da
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 NCBI Official Full Name    activin receptor type-2B
 NCBI Official Synonym Full Names    activin A receptor type 2B
 NCBI Official Symbol    ACVR2B [Similar Products]
 NCBI Official Synonym Symbols   
HTX4; ACTRIIB; ActR-IIB
[Similar Products]
 NCBI Protein Information    activin receptor type-2B
 UniProt Protein Name    Activin receptor type-2B
 UniProt Synonym Protein Names   
Activin receptor type IIB; ACTR-IIB
 UniProt Gene Name    ACVR2B [Similar Products]
 UniProt Synonym Gene Names    ACTR-IIB [Similar Products]
 UniProt Entry Name    AVR2B_HUMAN
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 NCBI Summary for ACVR2B    Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACVR2B    ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor.

Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type2 subfamily

Chromosomal Location of Human Ortholog: 3p22

Cellular Component: cytoplasm; integral to plasma membrane; plasma membrane; protein complex; receptor complex

Molecular Function: activin receptor activity, type II; growth factor binding; protein binding; protein serine/threonine kinase activity

Biological Process: activin receptor signaling pathway; anterior/posterior pattern formation; blood vessel remodeling; BMP signaling pathway; lymphangiogenesis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of activin receptor signaling pathway; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; regulation of transcription, DNA-dependent; signal transduction; transmembrane receptor protein serine/threonine kinase signaling pathway

Disease: Heterotaxy, Visceral, 4, Autosomal
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 Research Articles on ACVR2B    1. ActR-IIB is expressed in male germ cells and Sertoli cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACVR2B antibodyPathways associated with anti-ACVR2B antibody
 Reference Product  PubMed Publications
 SMAD2 antibody  >14 publications with ACVR2B and SMAD2
 MSTN antibody  >13 publications with ACVR2B and MSTN
 BMP2 antibody  >9 publications with ACVR2B and BMP2
 SMAD3 antibody  >8 publications with ACVR2B and SMAD3
 BMPR1A antibody  >7 publications with ACVR2B and BMPR1A
 SMAD5 antibody  >3 publications with ACVR2B and SMAD5
 ACVR1B antibody  >3 publications with ACVR2B and ACVR1B
 ACVRL1 antibody  >2 publications with ACVR2B and ACVRL1
 INHBA antibody  >1 publications with ACVR2B and INHBA
 Products by Pathway  Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Factors And Pathways Affecting Insulin-like Growth Factor (IGF1)-Akt Signaling antibodies  Factors And Pathways Affecting Insulin-like Growth Factor (IGF1)-Akt Signaling Diagram
 Mesodermal Commitment Pathway antibodies  Mesodermal Commitment Pathway Diagram
 Regulation Of Signaling By NODAL Pathway antibodies  Regulation Of Signaling By NODAL Pathway Diagram
Diseases associated with anti-ACVR2B antibodyOrgans/Tissues associated with anti-ACVR2B antibody
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >10 publications with ACVR2B and Congenital Abnormalities
 Hypertrophy Antibodies  >5 publications with ACVR2B and Hypertrophy
 Nervous System Diseases Antibodies  >5 publications with ACVR2B and Nervous System Diseases
 Disease Models, Animal Antibodies  >4 publications with ACVR2B and Disease Models, Animal
 Situs Inversus Antibodies  >4 publications with ACVR2B and Situs Inversus
 Weight Loss Antibodies  >3 publications with ACVR2B and Weight Loss
 Atrophy Antibodies  >3 publications with ACVR2B and Atrophy
 Inflammation Antibodies  >3 publications with ACVR2B and Inflammation
 Genital Diseases, Female Antibodies  >3 publications with ACVR2B and Genital Diseases, Female
 Heterotaxy Syndrome Antibodies  >3 publications with ACVR2B and Heterotaxy Syndrome
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >7 publications with ACVR2B and Heart
 Ovary Antibodies  >6 publications with ACVR2B and Ovary
 Kidney Antibodies  >5 publications with ACVR2B and Kidney
 Connective Tissue Antibodies  >5 publications with ACVR2B and Connective Tissue
 Embryonic Tissue Antibodies  >5 publications with ACVR2B and Embryonic Tissue
 Lung Antibodies  >4 publications with ACVR2B and Lung
 Testis Antibodies  >3 publications with ACVR2B and Testis
 Brain Antibodies  >3 publications with ACVR2B and Brain
 Pancreas Antibodies  >2 publications with ACVR2B and Pancreas
 Pituitary Gland Antibodies  >1 publications with ACVR2B and Pituitary Gland
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