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anti-ACY1 antibody :: Mouse ACY1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS533326
Unit / Price
0.1 mL  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ACY1, Monoclonal Antibody

 Also Known As   

ACY1 antibody

 Product Synonym Names    Monoclonal ACY1; Anti-ACY1; ACY1D; ACYLASE; Aminoacylase 1; ACY1; ACY 1; ACY-1
 Product Gene Name   

anti-ACY1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    104620
 3D Structure    ModBase 3D Structure for Q03154
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    1B12
 Host    Mouse
 Species Reactivity    Human, Dog, Rat, Mouse
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 Purity/Purification    ACY1 antibody was purified by affinity chromatography.
 Form/Format    Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
 Concentration    500 ug-1 mg/ml (lot specific)
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 Biological Significance    ACY1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D). ACY1D results in a metabolic disorder manifesting with encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urin ary excretion of several N-acetylated amino acids.
 Immunogen    ACY1 antibody was raised in mouse using a full length recombinant protein of human ACY1 (NP_000657) produced in HEk293 cell as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-ACY1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACY1 antibody

   Mouse monoclonal ACY1 antibody
 Product Categories/Family for anti-ACY1 antibody    Proteases, Inhibitors, & Enzymes
 Applications Tested/Suitable for anti-ACY1 antibody   

Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-ACY1 antibody    FC: 1:100
IHC: 1:150
WB: 1:200-500
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 Western Blot (WB) of anti-ACY1 antibody    Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant ACY1 protein (Right) or empty vector (Left) detected with ACY1 antibody
anti-ACY1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ACY1 antibody    Immunohistochemical analysis of ACY1 protein in paraffin embedded Human liver tissue using ACY1 antibody
anti-ACY1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ACY1. It may not necessarily be applicable to this product.
 NCBI GI #    4501901
 NCBI GeneID    95
 NCBI Accession #    NP_000657 [Other Products]
 NCBI GenBank Nucleotide #    NM_000666.2 [Other Products]
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 UniProt Primary Accession #    Q03154 [Other Products]
 UniProt Secondary Accession #    C9J6I6; C9J9D8; C9JWD4 [Other Products]
 UniProt Related Accession #    Q03154 [Other Products]
 Molecular Weight    42,195 Da
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 NCBI Official Full Name    aminoacylase-1 isoform a
 NCBI Official Synonym Full Names    aminoacylase 1
 NCBI Official Symbol    ACY1 [Similar Products]
 NCBI Official Synonym Symbols   
ACY-1; ACY1D; HEL-S-5
[Similar Products]
 NCBI Protein Information    aminoacylase-1
 UniProt Protein Name    Aminoacylase-1
 UniProt Synonym Protein Names   
N-acyl-L-amino-acid amidohydrolase
 Protein Family    Aminoacylase
 UniProt Gene Name    ACY1 [Similar Products]
 UniProt Synonym Gene Names    ACY-1 [Similar Products]
 UniProt Entry Name    ACY1_HUMAN
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 NCBI Summary for ACY1    This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010]
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 UniProt Comments for ACY1    ACY1: Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate). Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D). ACY1D results in a metabolic disorder manifesting with encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids. Belongs to the peptidase M20A family.

Protein type: Hydrolase; EC 3.5.1.14; Amino Acid Metabolism - arginine and proline

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: cytosol

Molecular Function: metallopeptidase activity; metal ion binding; aminoacylase activity

Biological Process: amino acid metabolic process; xenobiotic metabolic process; proteolysis

Disease: Aminoacylase 1 Deficiency
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 Research Articles on ACY1    1. Biochemical analysis showed absence of ACY1 enzyme activity in the patient's fibroblasts.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACY1 antibodyPathways associated with anti-ACY1 antibody
 Reference Product  PubMed Publications
 OTC antibody  >1 publications with ACY1 and OTC
 GLB1 antibody  >1 publications with ACY1 and GLB1
 ASPA antibody  >1 publications with ACY1 and ASPA
 SPHK1 antibody  >1 publications with ACY1 and SPHK1
 Products by Pathway  Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 2-Oxocarboxylic Acid Metabolism Pathway antibodies  2-Oxocarboxylic Acid Metabolism Pathway Diagram
 Aflatoxin Activation And Detoxification Pathway antibodies  Aflatoxin Activation And Detoxification Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Antibiotics Pathway antibodies  Biosynthesis Of Antibiotics Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
Diseases associated with anti-ACY1 antibodyOrgans/Tissues associated with anti-ACY1 antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >8 publications with ACY1 and Adenocarcinoma
 Carcinoma, Renal Cell Antibodies  >6 publications with ACY1 and Carcinoma, Renal Cell
 Kidney Diseases Antibodies  >5 publications with ACY1 and Kidney Diseases
 Liver Diseases Antibodies  >4 publications with ACY1 and Liver Diseases
 Liver Neoplasms Antibodies  >4 publications with ACY1 and Liver Neoplasms
 Kidney Neoplasms Antibodies  >3 publications with ACY1 and Kidney Neoplasms
 Carcinoma, Hepatocellular Antibodies  >3 publications with ACY1 and Carcinoma, Hepatocellular
 Aminoacylase 1 deficiency Antibodies  >3 publications with ACY1 and Aminoacylase 1 deficiency
 Neoplasm Metastasis Antibodies  >1 publications with ACY1 and Neoplasm Metastasis
 Congenital Abnormalities Antibodies  >1 publications with ACY1 and Congenital Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >8 publications with ACY1 and Lung
 Kidney Antibodies  >7 publications with ACY1 and Kidney
 Liver Antibodies  >6 publications with ACY1 and Liver
 Blood Antibodies  >3 publications with ACY1 and Blood
 Brain Antibodies  >2 publications with ACY1 and Brain
 Muscle Antibodies  >1 publications with ACY1 and Muscle
 Lymph Node Antibodies  >1 publications with ACY1 and Lymph Node
 Embryonic Tissue Antibodies  >1 publications with ACY1 and Embryonic Tissue
 Bone Antibodies  >1 publications with ACY1 and Bone
 Prostate Antibodies  >1 publications with ACY1 and Prostate
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