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anti-ADAM8 antibody :: Mouse anti-Human ADAM8 Ectodomain Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS605246 anti-ADAM8 antibody
Unit / Price
0.1 mg  /  $630 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADAM8 Ectodomain, Monoclonal Antibody

 Also Known As   

ADAM8 Ectodomain (a Disintegrin and Metalloproteinase Domain 8, MS2, CD156, CD156 MS2)

 Product Synonym Names    Anti -ADAM8 Ectodomain (a Disintegrin and Metalloproteinase Domain 8, MS2, CD156, CD156 MS2)
 Product Gene Name   

anti-ADAM8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_000010.10 (135075920..135090407, complement). Location: 10q26.3
 OMIM    602267
 3D Structure    ModBase 3D Structure for P78325
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    9H24
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human ADAM8.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a lyophilized powder in 0.2um sterile-filtered solution, PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS.
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 Immunogen    NS0-derived, recombinant human A Disintegrin and Metalloprotease-like Domain 8 ectodomain aa158-653.
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 Preparation and Storage    Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-ADAM8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ADAM8 antibody    Antibodies; Abs to Matrix Metalloproteinases
 Applications Tested/Suitable for anti-ADAM8 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-ADAM8 antibody    Suitable for use in ELISA, Western Blot, and Immunoprecipitation.
Dilution: ELISA: 1.0ug/ml
Western Blot: 1-2ug/ml
Immunoprecipitation: 25ug/ml
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NCBI/Uniprot data below describe general gene information for ADAM8. It may not necessarily be applicable to this product.
 NCBI GI #    109731932
 NCBI GeneID    101
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 UniProt Primary Accession #    P78325 [Other Products]
 UniProt Related Accession #    P78325; Q14C66 [Other Products]
 Molecular Weight    88,673 Da [Similar Products]
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 NCBI Official Full Name    ADAM8 protein
 NCBI Official Synonym Full Names    ADAM metallopeptidase domain 8
 NCBI Official Symbol    ADAM8 [Similar Products]
 NCBI Official Synonym Symbols   
MS2; CD156; MGC134985
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 8; cell surface antigen MS2; human leukocyte differentiation antigen; a disintegrin and metalloproteinase domain 8
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 8
 UniProt Synonym Protein Names   
Cell surface antigen MS2
 Protein Family    Disintegrin and metalloproteinase domain-containing protein
 UniProt Gene Name    ADAM8 [Similar Products]
 UniProt Synonym Gene Names    MS2 [Similar Products]
 UniProt Entry Name    ADAM8_HUMAN
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 NCBI Summary for ADAM8    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
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 UniProt Comments for ADAM8    ADAM8: Possible involvement in extravasation of leukocytes.

Protein type: Motility/polarity/chemotaxis; EC 3.4.24.-; Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q26.3

Cellular Component: specific granule; cell surface; integral to plasma membrane; cytoplasm; plasma membrane; podosome; dense core granule membrane

Molecular Function: protein binding; protein self-association; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; calcium ion binding; cell adhesion molecule binding

Biological Process: extracellular matrix organization and biogenesis; positive regulation of cell adhesion; cell morphogenesis; proteolysis; positive regulation of membrane protein ectodomain proteolysis; leukocyte migration during inflammatory response; activation of NF-kappaB transcription factor; positive regulation of T cell differentiation in the thymus; extracellular matrix disassembly; positive regulation of protein kinase B signaling cascade; cell-cell adhesion; regulation of cell-cell adhesion; positive regulation of protein secretion; positive regulation of acute inflammatory response; positive regulation of bone resorption; negative regulation of neuron apoptosis; angiogenesis; inflammatory response; lymphocyte chemotaxis
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 Research Articles on ADAM8    1. It regulates onset of blood circulation. (review)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Organs/Tissues associated with anti-ADAM8 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >29 publications with ADAM8 and Blood
 Lung Antibodies  >16 publications with ADAM8 and Lung
 Brain Antibodies  >9 publications with ADAM8 and Brain
 Bone Marrow Antibodies  >5 publications with ADAM8 and Bone Marrow
 Connective Tissue Antibodies  >5 publications with ADAM8 and Connective Tissue
 Kidney Antibodies  >4 publications with ADAM8 and Kidney
 Spleen Antibodies  >2 publications with ADAM8 and Spleen
 Prostate Antibodies  >2 publications with ADAM8 and Prostate
 Stomach Antibodies  >2 publications with ADAM8 and Stomach
 Thymus Antibodies  >2 publications with ADAM8 and Thymus
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