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anti-ADAMTS5 antibody :: Mouse anti-Human ADAMTS5 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS605109 anti-ADAMTS5 antibody
Unit / Price
0.1 mg  /  $630 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADAMTS5, Monoclonal Antibody

 Also Known As   

ADAMTS5 (Aggrecanase 2, A Disintegrin And Metalloproteinase with Thrombospondin-3 motif)

 Product Synonym Names    Anti -ADAMTS5 (Aggrecanase 2, A Disintegrin And Metalloproteinase with Thrombospondin-3 motif)
 Product Gene Name   

anti-ADAMTS5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 21; NC_000021.8 (28290231..28339439, complement). Location: 21q21.3
 OMIM    605007
 3D Structure    ModBase 3D Structure for Q9UNA0
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    9H41
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human ADAMTS5.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a lyophilized powder in 0.2um sterile-filtered solution, PBS, 5% trehalose. Reconstitute with 40-50% glycerol, PBS.
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 Immunogen    NS0-derived, recombinant human ADAMTS5; aa262- 622.
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 Preparation and Storage    Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-ADAMTS5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ADAMTS5 antibody

   ADAMTS5, also known as aggrecanase-2 and ADADMTS11, ADAMTS5 precursor consists of multiple domains. The purified rhADAMTS5 starts at the N-terminus of the catalytic domain and ends at the C-terminus of the TSP-1 domain. The amino acid sequence of rhADAMTS5 is 98%, 97%, and 96% identical to that of canine, bovine, and mouse/rat.
 Product Categories/Family for anti-ADAMTS5 antibody    Antibodies; Abs to Matrix Metalloproteinases
 Applications Tested/Suitable for anti-ADAMTS5 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-ADAMTS5 antibody    Suitable for use in ELISA, Western Blot, Immunoprecipitation.
Dilution: ELISA: 0.5-1.0ug/ml
Western Blot: 1-2ug/ml
Immunoprecipitation: 25ug/ml
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NCBI/Uniprot data below describe general gene information for ADAMTS5. It may not necessarily be applicable to this product.
 NCBI GI #    195539372
 NCBI GeneID    11096
 NCBI Accession #    NP_008969.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_007038.3 [Other Products]
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 UniProt Primary Accession #    Q9UNA0 [Other Products]
 UniProt Secondary Accession #    Q52LV4; Q9UKP2 [Other Products]
 UniProt Related Accession #    Q9UNA0 [Other Products]
 Molecular Weight    101,718 Da [Similar Products]
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 5 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif, 5
 NCBI Official Symbol    ADAMTS5 [Similar Products]
 NCBI Official Synonym Symbols   
ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; FLJ36738; ADAM-TS 5; ADAMTS-11; ADAM-TS 11
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 5; aggrecanase-2; OTTHUMP00000096353; a disintegrin and metalloproteinase with thrombospondin motifs 11; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 5
 UniProt Synonym Protein Names   
A disintegrin and metalloproteinase with thrombospondin motifs 11; ADAM-TS 11; ADAMTS-11; ADMP-2; Aggrecanase-2
 Protein Family    A disintegrin and metalloproteinase with thrombospondin motifs
 UniProt Gene Name    ADAMTS5 [Similar Products]
 UniProt Synonym Gene Names    ADAMTS11; ADMP2 [Similar Products]
 UniProt Entry Name    ATS5_HUMAN
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 NCBI Summary for ADAMTS5    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq]
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 UniProt Comments for ADAMTS5    ADAMTS5: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.

Protein type: Motility/polarity/chemotaxis; EC 3.4.24.-; Extracellular matrix; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 21q21.3

Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum lumen; extracellular region

Molecular Function: integrin binding; protein binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity

Biological Process: extracellular matrix disassembly; protein amino acid O-linked glycosylation; extracellular matrix organization and biogenesis; cellular protein metabolic process; defense response to bacterium; proteolysis; post-translational protein modification
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 Research Articles on ADAMTS5    1. Structure analysis with a succinamide inhibitor reveals the flexibility of the ADAMTS-5 active site.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADAMTS5 antibodyPathways associated with anti-ADAMTS5 antibody
 Reference Product  PubMed Publications
 MMP13 antibody  >15 publications with ADAMTS5 and MMP13
 ACAN antibody  >2 publications with ADAMTS5 and ACAN
 Products by Pathway  Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
Diseases associated with anti-ADAMTS5 antibodyOrgans/Tissues associated with anti-ADAMTS5 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >14 publications with ADAMTS5 and Inflammation
 Sarcoma Antibodies  >3 publications with ADAMTS5 and Sarcoma
 Skin Diseases Antibodies  >3 publications with ADAMTS5 and Skin Diseases
 Fibrosis Antibodies  >3 publications with ADAMTS5 and Fibrosis
 Glioblastoma Antibodies  >2 publications with ADAMTS5 and Glioblastoma
 Brain Neoplasms Antibodies  >2 publications with ADAMTS5 and Brain Neoplasms
 Congenital Abnormalities Antibodies  >2 publications with ADAMTS5 and Congenital Abnormalities
 Prostatic Neoplasms Antibodies  >1 publications with ADAMTS5 and Prostatic Neoplasms
 Head and Neck Neoplasms Antibodies  >1 publications with ADAMTS5 and Head and Neck Neoplasms
 Arteriosclerosis Antibodies  >1 publications with ADAMTS5 and Arteriosclerosis
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >38 publications with ADAMTS5 and Connective Tissue
 Brain Antibodies  >7 publications with ADAMTS5 and Brain
 Muscle Antibodies  >6 publications with ADAMTS5 and Muscle
 Embryonic Tissue Antibodies  >5 publications with ADAMTS5 and Embryonic Tissue
 Skin Antibodies  >3 publications with ADAMTS5 and Skin
 Eye Antibodies  >3 publications with ADAMTS5 and Eye
 Liver Antibodies  >2 publications with ADAMTS5 and Liver
 Lung Antibodies  >2 publications with ADAMTS5 and Lung
 Ovary Antibodies  >2 publications with ADAMTS5 and Ovary
 Ear Antibodies  >1 publications with ADAMTS5 and Ear
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