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anti-ADH1B antibody :: Mouse anti-Human ADH1B Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS831544
Unit / Price
0.1 mL  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ADH1B, Monoclonal Antibody

 Also Known As   

ADH1B antibody

 Product Synonym Names    Monoclonal ADH1B; Anti-ADH1B; Alcohol Dehydrogenase Ib; ADH2; DKFZp686C06125; Alcohol Dehydrogenase Class I beta polypeptide; ADH1B; ADHB 1; ADHB-1
 Product Gene Name   

anti-ADH1B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    103720
 3D Structure    ModBase 3D Structure for P00325
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    3C12
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    ADH1B antibody was purified by affinity chromatography.
 Form/Format    Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
 Concentration    500 ug-1 mg/ml (lot specific)
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 Biological Significance    ADH1B is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism.
 Immunogen    ADH1B antibody was raised in mouse using a full length recombinant protein of human ADH1B (NP_000659) produced in HEK293T cells, as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-ADH1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ADH1B antibody

   Mouse monoclonal ADH1B antibody
 Product Categories/Family for anti-ADH1B antibody    Proteases, Inhibitors, & Enzymes
 Applications Tested/Suitable for anti-ADH1B antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)

 Application Notes for anti-ADH1B antibody    FC: 1:100
IF: 1:100
WB: 1:2000
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 Western Blot (WB) of anti-ADH1B antibody    Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant ADH1B protein (Right) or empty vector (Left) detected with ADH1B antibody
anti-ADH1B antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-ADH1B antibody    Immunofluorescent staining of COS7 cells transiently transfected with recombinant ADH1B protein using ADH1B antibody
anti-ADH1B antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for ADH1B. It may not necessarily be applicable to this product.
 NCBI GI #    34577061
 NCBI GeneID    125
 NCBI Accession #    NP_000659 [Other Products]
 NCBI GenBank Nucleotide #    NM_000668.4 [Other Products]
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 UniProt Primary Accession #    P00325 [Other Products]
 UniProt Secondary Accession #    Q13711; Q4ZGI9; Q96KI7; A8MYN5; B4DRS9; B4DVC3 [Other Products]
 UniProt Related Accession #    P00325 [Other Products]
 Molecular Weight    35,412 Da
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 NCBI Official Full Name    alcohol dehydrogenase 1B isoform 1
 NCBI Official Synonym Full Names    alcohol dehydrogenase 1B (class I), beta polypeptide
 NCBI Official Symbol    ADH1B [Similar Products]
 NCBI Official Synonym Symbols   
ADH2; HEL-S-117
[Similar Products]
 NCBI Protein Information    alcohol dehydrogenase 1B
 UniProt Protein Name    Alcohol dehydrogenase 1B
 UniProt Synonym Protein Names   
Alcohol dehydrogenase subunit beta
 UniProt Gene Name    ADH1B [Similar Products]
 UniProt Synonym Gene Names    ADH2 [Similar Products]
 UniProt Entry Name    ADH1B_HUMAN
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 NCBI Summary for ADH1B    The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
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 UniProt Comments for ADH1B    ADH1B: Dimer of identical or non-identical chains of three types; alpha, beta and gamma. Belongs to the zinc-containing alcohol dehydrogenase family.

Protein type: Amino Acid Metabolism - tyrosine; Xenobiotic Metabolism - metabolism by cytochrome P450; Oxidoreductase; Lipid Metabolism - fatty acid; Cofactor and Vitamin Metabolism - retinol; EC 1.1.1.1; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: 4q23

Cellular Component: cytosol

Molecular Function: zinc ion binding; alcohol dehydrogenase activity, zinc-dependent

Biological Process: xenobiotic metabolic process; ethanol oxidation

Disease: Alcohol Dependence
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 Research Articles on ADH1B    1. This meta-analysis revealed that ADH1B Arg47His (rs1229984) polymorphism could increase the risk of HNC in Asians significantly.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ADH1B antibodyPathways associated with anti-ADH1B antibody
 Reference Product  PubMed Publications
 CYP2E1 antibody  >35 publications with ADH1B and CYP2E1
 ALDH1A1 antibody  >11 publications with ADH1B and ALDH1A1
 GSTM1 antibody  >5 publications with ADH1B and GSTM1
 GSTT1 antibody  >4 publications with ADH1B and GSTT1
 ALDH3A1 antibody  >4 publications with ADH1B and ALDH3A1
 ALDH1B1 antibody  >4 publications with ADH1B and ALDH1B1
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Ethanol Oxidation Pathway antibodies  Ethanol Oxidation Pathway Diagram
 Fatty Acid Omega Oxidation Pathway antibodies  Fatty Acid Omega Oxidation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
Diseases associated with anti-ADH1B antibodyOrgans/Tissues associated with anti-ADH1B antibody
 Disease Name  Pubmed Publications
 Alcoholism Antibodies  >138 publications with ADH1B and Alcoholism
 Genetic Predisposition to Disease Antibodies  >83 publications with ADH1B and Genetic Predisposition to Disease
 Esophageal Neoplasms Antibodies  >39 publications with ADH1B and Esophageal Neoplasms
 Liver Diseases Antibodies  >25 publications with ADH1B and Liver Diseases
 Esophageal Squamous Cell Carcinoma Antibodies  >20 publications with ADH1B and Esophageal Squamous Cell Carcinoma
 Colorectal Neoplasms Antibodies  >14 publications with ADH1B and Colorectal Neoplasms
 Nervous System Diseases Antibodies  >14 publications with ADH1B and Nervous System Diseases
 Central Nervous System Diseases Antibodies  >8 publications with ADH1B and Central Nervous System Diseases
 Carcinoma, Hepatocellular Antibodies  >8 publications with ADH1B and Carcinoma, Hepatocellular
 Death Antibodies  >7 publications with ADH1B and Death
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >49 publications with ADH1B and Liver
 Heart Antibodies  >15 publications with ADH1B and Heart
 Esophagus Antibodies  >14 publications with ADH1B and Esophagus
 Stomach Antibodies  >10 publications with ADH1B and Stomach
 Lung Antibodies  >8 publications with ADH1B and Lung
 Larynx Antibodies  >8 publications with ADH1B and Larynx
 Brain Antibodies  >7 publications with ADH1B and Brain
 Vascular Antibodies  >6 publications with ADH1B and Vascular
 Mouth Antibodies  >5 publications with ADH1B and Mouth
 Skin Antibodies  >4 publications with ADH1B and Skin
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