NP_006712.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,580 Da
NCBI Official Full Name
adenosine kinase isoform b
NCBI Official Synonym Full Names
adenosine kinase
NCBI Official Synonym Symbols
NCBI Protein Information
adenosine kinase; adenosine 5'-phosphotransferase
UniProt Protein Name
Adenosine kinase
UniProt Synonym Protein Names
Adenosine 5'-phosphotransferase
UniProt Synonym Gene Names
UniProt Entry Name
ADK_HUMAN
NCBI Summary for ADK
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
UniProt Comments for ADK
ADK: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. Defects in ADK are the cause of hypermethioninemia due to adenosine kinase deficiency (HMAKD). A metabolic disorder characterized by global developmental delay, early-onset seizures, mild dysmorphic features, and characteristic biochemical anomalies, including persistent hypermethioninemia with increased levels of S-adenosylmethionine and S-adenosylhomocysteine. Homocysteine levels are typically normal. Belongs to the carbohydrate kinase PfkB family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleotide Metabolism - purine; Kinase, other; EC 2.7.1.20
Chromosomal Location of Human Ortholog: 10q22|10q11-q24
Cellular Component: nucleoplasm; cytoplasm; cytosol
Molecular Function: metal ion binding; adenosine kinase activity; phosphotransferase activity, alcohol group as acceptor; ATP binding
Biological Process: nucleobase, nucleoside and nucleotide metabolic process; dATP biosynthetic process; ribonucleoside monophosphate biosynthetic process; positive regulation of T cell proliferation; circadian regulation of gene expression; adenosine metabolic process; phosphorylation; purine base metabolic process; purine salvage
Disease: Hypermethioninemia Due To Adenosine Kinase Deficiency
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Products associated with anti-ADK antibody
Pathways associated with anti-ADK antibody
Diseases associated with anti-ADK antibody
Organs/Tissues associated with anti-ADK antibody
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