NP_852107.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
activity-dependent neuroprotector homeobox protein
NCBI Official Synonym Full Names
activity-dependent neuroprotector homeobox
NCBI Protein Information
activity-dependent neuroprotector homeobox protein; ADNP homeobox 1; OTTHUMP00000031275; OTTHUMP00000031276; OTTHUMP00000165329; OTTHUMP00000229415; activity-dependent neuroprotective protein
UniProt Protein Name
Activity-dependent neuroprotector homeobox
UniProt Entry Name
Q6DHZ8_HUMAN
NCBI Summary for ADNP
Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq]
UniProt Comments for ADNP
ADNP: Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation.
Protein type: DNA-binding; C2H2-type zinc finger protein; Apoptosis
Chromosomal Location of Human Ortholog: 20q13.13
Cellular Component: extracellular space; nucleus
Molecular Function: protein binding; DNA binding; metal ion binding; chromatin binding
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; negative regulation of neuron apoptosis
Disease: Mental Retardation, Autosomal Dominant 28
Research Articles on ADNP
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Diseases associated with anti-ADNP antibody
Organs/Tissues associated with anti-ADNP antibody
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