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anti-AIF1 antibody :: Mouse anti-Human AIF1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS609673 anti-AIF1 antibody
Unit / Price
0.1 mg  /  $580 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AIF1, Monoclonal Antibody

 Also Known As   

AIF1 (Allograft Inflammatory Factor 1, AIF-1, DASS-82G15.2, G1, IBA1, IRT-1, Em:AF129756.17, Interferon gamma Responsive Transcript, IRT-1, Ionized Calcium-binding Adapter Molecule, Protein G1)

 Product Synonym Names    Anti -AIF1 (Allograft Inflammatory Factor 1, AIF-1, DASS-82G15.2, G1, IBA1, IRT-1, Em:AF129756.17, Interferon gamma Responsive Transcript, IRT-1, Ionized Calcium-binding Adapter Molecule, Protein G1)
 Product Gene Name   

anti-AIF1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q9UIV4
 Clonality    Monoclonal
 Isotype    IgG1, k
 Clone Number    2A2-B6
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human AIF1.
 Purity/Purification    Purified
Purified.
 Form/Format    Supplied as a liquid in PBS, pH 7.2.
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 Immunogen    AIF1 (AAH09474, 1-148aa) full length recombinant protein with GST tag. MW of the GST tag alone is 26kD.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-AIF1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-AIF1 antibody

   AIF-1 is a 17kD IFN-gamma inducible Ca2+-binding EF-hand protein, associated with chronic inflammatory processes. AIF-1 is constitutively expressed in lymphatic tissue and is up-regulated in monocytes/macrophages under various pathological conditions such as chronic rejection of allografts and in autoimmune lesions. In the brain, a subset of microglial cells constitutively express AIF-1. Increased numbers of AIF-1 immunoreactive macrophage/microglial cells were observed in focal brain infarctions, traumatic brain injury, gliomas, uveitis and in inflammatory lesions of a rat model of autoimmune disease, autoimmune encephalomyelitis and neuritis. Several Ca2+-binding peptides have been associated with monocyte activation, in particular members of the S-100 supergene-family. AIF-1 is a Ca2+-binding peptide which is not a member of the S-100 gene cluster but is located within the HLA class III genomic region.
 Product Categories/Family for anti-AIF1 antibody    Antibodies; Abs to Actin Related Proteins
 Applications Tested/Suitable for anti-AIF1 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-AIF1 antibody    Suitable for use in ELISA and Western Blot.
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NCBI/Uniprot data below describe general gene information for AIF1. It may not necessarily be applicable to this product.
 NCBI GI #    49457302
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 UniProt Primary Accession #    Q9UIV4 [Other Products]
 Molecular Weight    10,455 Da [Similar Products]
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 NCBI Official Full Name    AIF1
 UniProt Protein Name    AIF1 protein
 Protein Family    Apoptosis-inducing factor
 UniProt Gene Name    AIF1 [Similar Products]
 UniProt Entry Name    Q9UIV4_HUMAN
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 NCBI Summary for AIF1    This gene is induced by cytokines and interferon. Its protein product is thought to be involved in negative regulation of growth of vascular smooth muscle cells, which contributes to the anti-inflammatory response to vessel wall trauma. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
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 UniProt Comments for AIF1    AIF1: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T- lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: perinuclear region of cytoplasm; lamellipodium; cytoplasm; perikaryon; actin filament; cytosol; nucleus; phagocytic cup

Molecular Function: actin filament binding; calcium ion binding

Biological Process: actin filament bundle formation; positive regulation of nitric oxide biosynthetic process; negative regulation of smooth muscle cell proliferation; positive regulation of smooth muscle cell proliferation; microglial cell activation; Rac protein signal transduction; cellular response to hormone stimulus; actin filament polymerization; positive regulation of muscle hyperplasia; cellular response to extracellular stimulus; positive regulation of T cell proliferation; positive regulation of protein amino acid phosphorylation; response to axon injury; response to electrical stimulus; inflammatory response; phagocytosis, engulfment; negative regulation of apoptosis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to AIF1 (Allograft Inflammatory Factor 1, AIF-1, DASS-82G15.2, G1, IBA1, IRT-1,
 Catalog #  Product Name  Catalog #  Product Name
 MBS9408927  AIF1 Antibody  MBS1167608  Recombinant Bovine Nuclear apoptosis-inducing factor 1 (NAIF1)
 MBS203771  AIF1, 1-147aa, Human, His tag, E Coli  MBS2064627  APC/CY7-Linked Monoclonal Antibody to Allograft Inflammatory Factor 1 (AIF1)
 MBS1493970  NAIF1 Antibody, HRP conjugated  MBS9411939  AIF1 antibody
 MBS7234570  Monkey Allograft inflammatory factor 1-like (AIF1L) ELISA Kit  MBS2005428  Biotin-Linked Antibody to Allograft Inflammatory Factor 1 (AIF1)
 MBS2543754  Mouse anti Human IBA1/AIF1 Monoclonal Antibody  MBS7229206  Goat Allograft inflammatory factor 1-like (AIF1L) ELISA Kit
Products associated with anti-AIF1 antibodyPathways associated with anti-AIF1 antibody
 Reference Product  PubMed Publications
 FLNA antibody  >12 publications with AIF1 and FLNA
 Products by Pathway  Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
Diseases associated with anti-AIF1 antibodyOrgans/Tissues associated with anti-AIF1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >157 publications with AIF1 and Nervous System Diseases
 Inflammation Antibodies  >68 publications with AIF1 and Inflammation
 Autoimmune Diseases Antibodies  >29 publications with AIF1 and Autoimmune Diseases
 Neoplasms Antibodies  >16 publications with AIF1 and Neoplasms
 Skin Diseases Antibodies  >15 publications with AIF1 and Skin Diseases
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >13 publications with AIF1 and Encephalomyelitis, Autoimmune, Experimental
 Drug Toxicity Antibodies  >10 publications with AIF1 and Drug Toxicity
 Poisoning Antibodies  >9 publications with AIF1 and Poisoning
 Edema Antibodies  >7 publications with AIF1 and Edema
 Arteriosclerosis Antibodies  >6 publications with AIF1 and Arteriosclerosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >186 publications with AIF1 and Brain
 Blood Antibodies  >76 publications with AIF1 and Blood
 Vascular Antibodies  >42 publications with AIF1 and Vascular
 Muscle Antibodies  >28 publications with AIF1 and Muscle
 Bone Marrow Antibodies  >18 publications with AIF1 and Bone Marrow
 Heart Antibodies  >13 publications with AIF1 and Heart
 Skin Antibodies  >11 publications with AIF1 and Skin
 Eye Antibodies  >11 publications with AIF1 and Eye
 Embryonic Tissue Antibodies  >9 publications with AIF1 and Embryonic Tissue
 Kidney Antibodies  >7 publications with AIF1 and Kidney
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