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anti-AK1 antibody :: Mouse AK1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS830065
Unit / Price
0.1 mL  /  $515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AK1, Monoclonal Antibody

 Also Known As   

AK1 antibody

 Product Synonym Names    Monoclonal AK1; Anti-AK1; Adenylate Kinase 1; AK1; AK 1; AK-1
 Product Gene Name   

anti-AK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    103000
 3D Structure    ModBase 3D Structure for P00568
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    8A1
 Host    Mouse
 Species Reactivity    Human, Monkey
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 Purity/Purification    AK1 antibody was purified by affinity chromatography.
 Form/Format    Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
 Concentration    500 ug-1 mg/ml (lot specific)
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 Biological Significance    Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme.
 Immunogen    AK1 antibody was raised in mouse using a full length recombinant protein of human AK1 (NP_000467) produced in HEK293T cells, as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-AK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-AK1 antibody

   Mouse monoclonal AK1 antibody
 Product Categories/Family for anti-AK1 antibody    Proteases, Inhibitors, & Enzymes
 Applications Tested/Suitable for anti-AK1 antibody   

Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB)

 Application Notes for anti-AK1 antibody    FC: 1:100
IF: 1:100
WB: 1:2500-5000
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 Western Blot (WB) of anti-AK1 antibody    Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant AK1 protein (Right) or empty vector (Left) detected with AK1 antibody
anti-AK1 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-AK1 antibody    Immunofluorescent staining of COS7 cells transiently transfected with recombinant AK1 protein using AK1 antibody
anti-AK1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for AK1. It may not necessarily be applicable to this product.
 NCBI GI #    4502011
 NCBI GeneID    203
 NCBI Accession #    NP_000467 [Other Products]
 NCBI GenBank Nucleotide #    NM_000476.2 [Other Products]
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 UniProt Primary Accession #    P00568 [Other Products]
 UniProt Secondary Accession #    Q9BVK9; Q9UQC7 [Other Products]
 UniProt Related Accession #    P00568 [Other Products]
 Molecular Weight    21,635 Da
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 NCBI Official Full Name    adenylate kinase isoenzyme 1
 NCBI Official Synonym Full Names    adenylate kinase 1
 NCBI Official Symbol    AK1 [Similar Products]
 NCBI Official Synonym Symbols   
HTL-S-58j
[Similar Products]
 NCBI Protein Information    adenylate kinase isoenzyme 1
 UniProt Protein Name    Adenylate kinase isoenzyme 1
 UniProt Synonym Protein Names   
ATP-AMP transphosphorylase 1
 Protein Family    Adenylate kinase
 UniProt Gene Name    AK1 [Similar Products]
 UniProt Synonym Gene Names    AK 1 [Similar Products]
 UniProt Entry Name    KAD1_HUMAN
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 NCBI Summary for AK1    Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AK1    AK1: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency (HAAKD). Belongs to the adenylate kinase family.

Protein type: EC 2.7.4.3; Kinase, other; Nucleotide Metabolism - purine; EC 2.7.4.6

Chromosomal Location of Human Ortholog: 9q34.1

Cellular Component: cytoplasm; plasma membrane; outer dense fiber; cytosol

Molecular Function: nucleoside diphosphate kinase activity; adenylate kinase activity; ATP binding

Biological Process: ATP metabolic process; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside and nucleotide interconversion; nucleoside triphosphate biosynthetic process; ADP biosynthetic process; nucleoside diphosphate phosphorylation; AMP metabolic process; cell cycle arrest

Disease: Adenylate Kinase Deficiency, Hemolytic Anemia Due To
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 Research Articles on AK1    1. Studies indicate that the preferred substrate and phosphate donor of all adenylate kinases are AMP and ATP respectively.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AK1 antibodyPathways associated with anti-AK1 antibody
 Reference Product  PubMed Publications
 ADK antibody  >4 publications with AK1 and ADK
 ADSL antibody  >1 publications with AK1 and ADSL
 ENTPD3 antibody  >1 publications with AK1 and ENTPD3
 Products by Pathway  Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway antibodies  Adenine Ribonucleotide Biosynthesis, IMP => ADP,ATP Pathway Diagram
 Biosynthesis Of Antibiotics Pathway antibodies  Biosynthesis Of Antibiotics Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway antibodies  Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway Diagram
 Adenosine Ribonucleotides De Novo Biosynthesis Pathway antibodies  Adenosine Ribonucleotides De Novo Biosynthesis Pathway Diagram
Diseases associated with anti-AK1 antibodyOrgans/Tissues associated with anti-AK1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >16 publications with AK1 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >13 publications with AK1 and Congenital Abnormalities
 Chromosome Aberrations Antibodies  >12 publications with AK1 and Chromosome Aberrations
 Brain Diseases Antibodies  >10 publications with AK1 and Brain Diseases
 Heart Diseases Antibodies  >8 publications with AK1 and Heart Diseases
 Disease Models, Animal Antibodies  >4 publications with AK1 and Disease Models, Animal
 Adenylate Kinase Deficiency, Hemolytic Anemia Due To Antibodies  >4 publications with AK1 and Adenylate Kinase Deficiency, Hemolytic Anemia Due To
 Myocardial Ischemia Antibodies  >4 publications with AK1 and Myocardial Ischemia
 Breast Neoplasms Antibodies  >2 publications with AK1 and Breast Neoplasms
 Liver Diseases Antibodies  >2 publications with AK1 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >91 publications with AK1 and Blood
 Muscle Antibodies  >47 publications with AK1 and Muscle
 Brain Antibodies  >21 publications with AK1 and Brain
 Heart Antibodies  >19 publications with AK1 and Heart
 Liver Antibodies  >14 publications with AK1 and Liver
 Nerve Antibodies  >7 publications with AK1 and Nerve
 Kidney Antibodies  >6 publications with AK1 and Kidney
 Vascular Antibodies  >5 publications with AK1 and Vascular
 Embryonic Tissue Antibodies  >4 publications with AK1 and Embryonic Tissue
 Eye Antibodies  >3 publications with AK1 and Eye
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