NP_006057
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,573 Da
NCBI Official Full Name
alcohol dehydrogenase
NCBI Official Synonym Full Names
aldo-keto reductase family 1, member A1 (aldehyde reductase)
NCBI Protein Information
alcohol dehydrogenase [NADP(+)]
UniProt Protein Name
Alcohol dehydrogenase [NADP(+)]
UniProt Synonym Protein Names
Aldehyde reductase; Aldo-keto reductase family 1 member A1
UniProt Synonym Gene Names
UniProt Entry Name
AK1A1_HUMAN
NCBI Summary for AKR1A1
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]
UniProt Comments for AKR1A1
AKR1A1: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Belongs to the aldo/keto reductase family.
Protein type: Lipid Metabolism - glycerolipid; EC 1.1.1.2; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Oxidoreductase
Chromosomal Location of Human Ortholog: 1p33-p32
Cellular Component: extracellular space; apical plasma membrane; cytosol
Molecular Function: L-glucuronate reductase activity; electron carrier activity; aldehyde reductase activity
Biological Process: aldehyde catabolic process; L-ascorbic acid biosynthetic process; D-glucuronate catabolic process; glucose metabolic process; aldehyde metabolic process
Research Articles on AKR1A1
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Products associated with anti-AKR1A1 antibody
Pathways associated with anti-AKR1A1 antibody
Diseases associated with anti-AKR1A1 antibody
Organs/Tissues associated with anti-AKR1A1 antibody
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