NM_001346142.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
35,853 Da
NCBI Official Full Name
aldose reductase isoform 2
NCBI Official Synonym Full Names
aldo-keto reductase family 1 member B
NCBI Protein Information
aldose reductase
UniProt Protein Name
Aldose reductase
UniProt Synonym Protein Names
Aldehyde reductase; Aldo-keto reductase family 1 member B1
UniProt Synonym Gene Names
UniProt Entry Name
ALDR_HUMAN
NCBI Summary for AKR1B1
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]
UniProt Comments for AKR1B1
AKR1B1: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. Belongs to the aldo/keto reductase family.
Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - pyruvate; EC 1.1.1.21; Lipid Metabolism - glycerolipid; Oxidoreductase
Chromosomal Location of Human Ortholog: 7q35
Cellular Component: cytoplasm; cytosol; nucleoplasm
Molecular Function: aldehyde reductase activity; aldo-keto reductase activity; electron carrier activity; glyceraldehyde oxidoreductase activity
Biological Process: C21-steroid hormone biosynthetic process; carbohydrate metabolic process; fructose biosynthetic process; response to stress
Research Articles on AKR1B1
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Products associated with anti-AKR1B1 antibody
Pathways associated with anti-AKR1B1 antibody
Diseases associated with anti-AKR1B1 antibody
Organs/Tissues associated with anti-AKR1B1 antibody
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