NP_001617
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
51,083 Da
NCBI Official Full Name
RAC-beta serine/threonine-protein kinase isoform 1
NCBI Official Synonym Full Names
v-akt murine thymoma viral oncogene homolog 2
NCBI Official Synonym Symbols
PKBB; PRKBB; HIHGHH; PKBBETA; RAC-BETA [Similar Products]
NCBI Protein Information
RAC-beta serine/threonine-protein kinase
UniProt Protein Name
RAC-beta serine/threonine-protein kinase
UniProt Synonym Protein Names
Protein kinase Akt-2; Protein kinase B beta; PKB beta; RAC-PK-beta
UniProt Synonym Gene Names
UniProt Entry Name
AKT2_HUMAN
NCBI Summary for AKT2
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq, Jul 2008]
UniProt Comments for AKT2
Akt2: an AGC kinase. Plays critical roles in glucose metabolism and the development or maintenance of proper adipose tissue and islet mass for which other Akt/PKB isoforms are unable to fully compensate. Amplified and overexpressed in human ovarian carcinoma cell lines and amplified in some primary ovarian and pancreatic tumors. Antisense blocks invasiveness in xenografts. Expressed in several insulin-responsive tissues, and one case of Type II diabetes has been associated with a likely LOF point mutation. Mouse mutants have defects in insulin response.
Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; Kinase, protein; Oncoprotein; EC 2.7.11.1; AGC group; AKT family
Chromosomal Location of Human Ortholog: 19q13.1-q13.2
Cellular Component: nucleoplasm; plasma membrane; cell cortex; nucleus; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; kinase activity; ATP binding
Biological Process: fat cell differentiation; glycogen biosynthetic process; apoptosis; carbohydrate transport; positive regulation of glycogen biosynthetic process; intracellular protein transport across a membrane; myelin maintenance in the peripheral nervous system; glucose metabolic process; protein modification process; positive regulation of vesicle fusion; signal transduction; protein amino acid phosphorylation; regulation of cell migration; positive regulation of fatty acid beta-oxidation; regulation of translation; positive regulation of glucose import; cellular response to insulin stimulus; insulin receptor signaling pathway; positive regulation of protein amino acid phosphorylation
Disease: Hypoinsulinemic Hypoglycemia With Hemihypertrophy; Diabetes Mellitus, Noninsulin-dependent
Research Articles on AKT2
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Products associated with anti-AKT2 antibody
Pathways associated with anti-AKT2 antibody
Diseases associated with anti-AKT2 antibody
Organs/Tissues associated with anti-AKT2 antibody
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