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anti-ALDH1A1 antibody :: Mouse anti-Human ALDH1A1 / ALDH1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245816
Unit / Price
0.05 mg  /  $555 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALDH1A1 / ALDH1, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone 1G6] (IgG2a,k) to Human ALDH1A1 / ALDH1

 Product Synonym Names    Anti-ALDH1A1 / ALDH1 Antibody (clone 1G6) IHC-plus; ALDH1A1; Acetaldehyde dehydrogenase 1; ALDH class 1; ALDC; Aldehyde dehydrogenase 1; ALDH-E1; ALDH1; ALDH11; PUMB1; RALDH 1; RALDH1; ALHDII; Retinal dehydrogenase 1; Retinaldehyde dehydrogenase 1; Human ALDH1A1; ALDH1
 Product Gene Name   

anti-ALDH1A1 antibody

[Similar Products]
 Product Synonym Gene Name    ALDH1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    100640
 3D Structure    ModBase 3D Structure for P00352
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 Clonality    Monoclonal
 Isotype    IgG2a,k
 Clone Number    1G6
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Human ALDH1A1
 Purity/Purification    Protein A Purified
 Form/Format    PBS, pH 7.4. Sourced in Ascites.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    ALDH1A1 (AAH01505, 1 a.a. ~ 502 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
 Immunogen    ALDH1A1 / ALDH1 antibody was raised against aLDH1A1 (AAH01505, 1 a.a. ~ 502 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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 Preparation and Storage    Store at -20 degree C or lower. Aliquot to avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-ALDH1A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ALDH1A1 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA)

 Application Notes for anti-ALDH1A1 antibody    ELISA, IHC-P (5 ug/ml), IP, WB (1:500 - 1:1000)
Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Sandwich ELISA: Recombinant protein. Western Blot: Transfected lysate, Recombinant protein.
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 Immunohistochemistry (IHC) of anti-ALDH1A1 antibody    Anti-ALDH1A1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-ALDH1A1 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-ALDH1A1 antibody    Western blot of ALDH1A1 expression in transfected 293T cell line. Lane 1: ALDH1A1 transfected lysate (Predicted MW: 54.9 KDa). Lane 2: Non-transfected lysate.
anti-ALDH1A1 antibody Western Blot (WB) (WB) image
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 Immunoprecipitation (IP) of anti-ALDH1A1 antibody    Immunoprecipitation of ALDH1A1 transfected lysate using anti-ALDH1A1 monoclonal antibody and Protein A Magnetic Bead.
anti-ALDH1A1 antibody Immunoprecipitation (IP) (IP) image
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 ELISA (EIA) of anti-ALDH1A1 antibody    Detection limit for recombinant GST tagged ALDH1A1 is 1 ng/ml as a capture antibody.
anti-ALDH1A1 antibody ELISA (EIA) image
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NCBI/Uniprot data below describe general gene information for ALDH1A1. It may not necessarily be applicable to this product.
 NCBI GI #    21361176
 NCBI GeneID    216
 NCBI Accession #    NP_000680.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000689.4 [Other Products]
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 UniProt Primary Accession #    P00352 [Other Products]
 UniProt Secondary Accession #    O00768; Q5SYR1 [Other Products]
 UniProt Related Accession #    P00352 [Other Products]
 Molecular Weight    54,862 Da
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 NCBI Official Full Name    retinal dehydrogenase 1
 NCBI Official Synonym Full Names    aldehyde dehydrogenase 1 family, member A1
 NCBI Official Symbol    ALDH1A1 [Similar Products]
 NCBI Official Synonym Symbols   
ALDC; ALDH1; HEL-9; HEL12; PUMB1; ALDH11; RALDH1; ALDH-E1; HEL-S-53e
[Similar Products]
 NCBI Protein Information    retinal dehydrogenase 1; ALHDII; RALDH 1; ALDH class 1; acetaldehyde dehydrogenase 1; epididymis luminal protein 9; epididymis luminal protein 12; retinaldehyde dehydrogenase 1; aldehyde dehydrogenase 1, soluble; aldehyde dehydrogenase, liver cytosolic; epididymis secretory sperm binding protein Li 53e
 UniProt Protein Name    Retinal dehydrogenase 1
 UniProt Synonym Protein Names   
ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic
 Protein Family    Retinal dehydrogenase
 UniProt Gene Name    ALDH1A1 [Similar Products]
 UniProt Synonym Gene Names    ALDC; ALDH1; PUMB1; RALDH 1; RalDH1 [Similar Products]
 UniProt Entry Name    AL1A1_HUMAN
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 NCBI Summary for ALDH1A1    The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]
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 UniProt Comments for ALDH1A1    ALDH1A1: Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid. Belongs to the aldehyde dehydrogenase family.

Protein type: Cofactor and Vitamin Metabolism - retinol; Apoptosis; GAPs; Oxidoreductase; EC 1.2.1.36; GAPs, Ras

Chromosomal Location of Human Ortholog: 9q21.13

Cellular Component: cytoplasm; cytosol

Molecular Function: aldehyde dehydrogenase (NAD) activity; androgen binding; 3-chloroallyl aldehyde dehydrogenase activity; benzaldehyde dehydrogenase (NAD+) activity; retinal dehydrogenase activity

Biological Process: retinol metabolic process; xenobiotic metabolic process; aldehyde metabolic process; ethanol oxidation
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 Research Articles on ALDH1A1    1. Our results provide the strong evidence that ALDH1A1(high) cancer stem-like cells contribute to the invasion, metastasis and poor outcome of human esophageal squamous cell carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ALDH1A1 antibodyPathways associated with anti-ALDH1A1 antibody
 Reference Product  PubMed Publications
 ADH1B antibody  >11 publications with ALDH1A1 and ADH1B
 CYP26B1 antibody  >9 publications with ALDH1A1 and CYP26B1
 CYP26A1 antibody  >7 publications with ALDH1A1 and CYP26A1
 CYP3A4 antibody  >5 publications with ALDH1A1 and CYP3A4
 ADH1A antibody  >4 publications with ALDH1A1 and ADH1A
 ADH5 antibody  >3 publications with ALDH1A1 and ADH5
 ADH7 antibody  >3 publications with ALDH1A1 and ADH7
 CYP26C1 antibody  >2 publications with ALDH1A1 and CYP26C1
 ADH6 antibody  >2 publications with ALDH1A1 and ADH6
 Products by Pathway  Pathway Diagram
 Biological Oxidations Pathway antibodies  Biological Oxidations Pathway Diagram
 Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway antibodies  Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway Diagram
 Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway antibodies  Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway Diagram
 Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway antibodies  Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway Diagram
 Defective CYP17A1 Causes Adrenal Hyperplasia 5 (AH5) Pathway antibodies  Defective CYP17A1 Causes Adrenal Hyperplasia 5 (AH5) Pathway Diagram
 Defective CYP19A1 Causes Aromatase Excess Syndrome (AEXS) Pathway antibodies  Defective CYP19A1 Causes Aromatase Excess Syndrome (AEXS) Pathway Diagram
 Defective CYP1B1 Causes Glaucoma Pathway antibodies  Defective CYP1B1 Causes Glaucoma Pathway Diagram
 Defective CYP21A2 Causes Adrenal Hyperplasia 3 (AH3) Pathway antibodies  Defective CYP21A2 Causes Adrenal Hyperplasia 3 (AH3) Pathway Diagram
 Defective CYP24A1 Causes Hypercalcemia, Infantile (HCAI) Pathway antibodies  Defective CYP24A1 Causes Hypercalcemia, Infantile (HCAI) Pathway Diagram
 Defective CYP26B1 Causes Radiohumeral Fusions With Other Skeletal And Craniofacial Anomalies (RHFCA) Pathway antibodies  Defective CYP26B1 Causes Radiohumeral Fusions With Other Skeletal And Craniofacial Anomalies (RHFCA) Pathway Diagram
Diseases associated with anti-ALDH1A1 antibodyOrgans/Tissues associated with anti-ALDH1A1 antibody
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >28 publications with ALDH1A1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >22 publications with ALDH1A1 and Breast Neoplasms
 Brain Diseases Antibodies  >18 publications with ALDH1A1 and Brain Diseases
 Neoplasms, Experimental Antibodies  >18 publications with ALDH1A1 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >17 publications with ALDH1A1 and Nervous System Diseases
 Liver Diseases Antibodies  >15 publications with ALDH1A1 and Liver Diseases
 Liver Neoplasms Antibodies  >12 publications with ALDH1A1 and Liver Neoplasms
 Parkinsonian Disorders Antibodies  >11 publications with ALDH1A1 and Parkinsonian Disorders
 Inflammation Antibodies  >8 publications with ALDH1A1 and Inflammation
 Liver Neoplasms, Experimental Antibodies  >7 publications with ALDH1A1 and Liver Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >42 publications with ALDH1A1 and Lung
 Liver Antibodies  >40 publications with ALDH1A1 and Liver
 Blood Antibodies  >38 publications with ALDH1A1 and Blood
 Brain Antibodies  >35 publications with ALDH1A1 and Brain
 Eye Antibodies  >28 publications with ALDH1A1 and Eye
 Bone Antibodies  >13 publications with ALDH1A1 and Bone
 Prostate Antibodies  >13 publications with ALDH1A1 and Prostate
 Intestine Antibodies  >12 publications with ALDH1A1 and Intestine
 Muscle Antibodies  >11 publications with ALDH1A1 and Muscle
 Kidney Antibodies  >10 publications with ALDH1A1 and Kidney
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