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anti-ALPP antibody :: Mouse anti-Human ALPP / PLAP / ALP Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245095
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ALPP / PLAP / ALP, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone H7E8] (IgG2a) to Human ALPP / PLAP / ALP

 Product Synonym Names    Anti-ALPP / PLAP / ALP Antibody (clone H7E8) IHC-plus; ALPP; ALP; Alkaline phosphomonoesterase; Glycerophosphatase; PALP; PLAP; PLAP-1; Alp1; Germ-cell alkaline phosphatase; Nagao isozyme; Regan isozyme; Human ALPP; PLAP; ALP
 Product Gene Name   

anti-ALPP antibody

[Similar Products]
 Product Synonym Gene Name    PLAP; ALP [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    171800
 3D Structure    ModBase 3D Structure for P05187
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    H7E8
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Purified placental alkaline phosphatase
 Purity/Purification    Protein A Purified
 Form/Format    PBS, 15 mM sodium azide, approx., pH 7.4. Sourced in TCS.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Purified human ALPP.
 Immunogen    ALPP / PLAP / ALP antibody was raised against purified human ALPP.
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-ALPP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ALPP antibody   

Immunohistochemistry (IHC - Paraffin; IHC - Frozen), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ALPP antibody    ELISA, IHC-Fr, IHC-P (10 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-ALPP antibody    Anti-ALPP antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-ALPP antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ALPP. It may not necessarily be applicable to this product.
 NCBI GI #    94721246
 NCBI GeneID    250
 NCBI Accession #    NP_001623.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_001632.4 [Other Products]
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 UniProt Primary Accession #    P05187 [Other Products]
 UniProt Secondary Accession #    P05188; P06861; Q53S78; Q96DB7 [Other Products]
 UniProt Related Accession #    P05187 [Other Products]
 Molecular Weight    57,954 Da
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 NCBI Official Full Name    alkaline phosphatase, placental type preproprotein
 NCBI Official Synonym Full Names    alkaline phosphatase, placental
 NCBI Official Symbol    ALPP [Similar Products]
 NCBI Official Synonym Symbols   
ALP; PALP; PLAP; PLAP-1
[Similar Products]
 NCBI Protein Information    alkaline phosphatase, placental type; glycerophosphatase; alkaline phosphomonoesterase; placental alkaline phosphatase 1; alkaline phosphatase Regan isozyme
 UniProt Protein Name    Alkaline phosphatase, placental type
 UniProt Synonym Protein Names   
Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1
 Protein Family    Alkaline phosphatase
 UniProt Gene Name    ALPP [Similar Products]
 UniProt Synonym Gene Names    PLAP; PLAP-1 [Similar Products]
 UniProt Entry Name    PPB1_HUMAN
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 NCBI Summary for ALPP    The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]
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 UniProt Comments for ALPP    ALPP: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2 while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme, also referred to as the heat stable form, that is expressed primarily in the placenta although it is closely related to the intestinal form of the enzyme as well as to the placental-like form. The coding sequence for this form of alkaline phosphatase is unique in that the 3' untranslated region contains multiple copies of an Alu family repeat. In addition, this gene is polymorphic and three common alleles (type 1, type 2 and type 3) for this form of alkaline phosphatase have been well characterized. [provided by RefSeq, Jul 2008]

Protein type: Membrane protein, GPI anchor; Cell surface; Membrane protein, integral; EC 3.1.3.1; Motility/polarity/chemotaxis; Cofactor and Vitamin Metabolism - folate biosynthesis; Phosphatase (non-protein)

Chromosomal Location of Human Ortholog: 2q37

Cellular Component: cell surface; integral to membrane; plasma membrane

Molecular Function: zinc ion binding; alkaline phosphatase activity; magnesium ion binding

Biological Process: dephosphorylation
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 Research Articles on ALPP    1. Anti-PLAP antibodies may serve as a modular building blocks for the development of targeted therapeutic products, armed with cytotoxic drugs, radionuclides or cytokines as payloads.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ALPP antibodyPathways associated with anti-ALPP antibody
 Reference Product  PubMed Publications
 PTS antibody  >1 publications with ALPP and PTS
 Products by Pathway  Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Pyridoxal 5'-phosphate Salvage Pathway antibodies  Pyridoxal 5'-phosphate Salvage Pathway Diagram
Diseases associated with anti-ALPP antibodyOrgans/Tissues associated with anti-ALPP antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >27 publications with ALPP and Adenocarcinoma
 Pregnancy Complications Antibodies  >23 publications with ALPP and Pregnancy Complications
 Nervous System Diseases Antibodies  >19 publications with ALPP and Nervous System Diseases
 Lung Diseases Antibodies  >12 publications with ALPP and Lung Diseases
 Breast Neoplasms Antibodies  >6 publications with ALPP and Breast Neoplasms
 Liver Diseases Antibodies  >5 publications with ALPP and Liver Diseases
 Pain Antibodies  >3 publications with ALPP and Pain
 Kidney Diseases Antibodies  >3 publications with ALPP and Kidney Diseases
 Hyperplasia Antibodies  >3 publications with ALPP and Hyperplasia
 Necrosis Antibodies  >3 publications with ALPP and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >85 publications with ALPP and Placenta
 Intestine Antibodies  >10 publications with ALPP and Intestine
 Heart Antibodies  >8 publications with ALPP and Heart
 Uterus Antibodies  >7 publications with ALPP and Uterus
 Amniotic Fluid Antibodies  >1 publications with ALPP and Amniotic Fluid
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