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anti-AMACRacemase antibody :: Rabbit anti-Human AMACRacemase Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS370005
Unit / Price
5 Control Slides  /  $130 +1 FREE 8GB USB
3 ml (Prediluted)  /  $220 +1 FREE 8GB USB
0.1 mL (Concentrate)  /  $225 +1 FREE 8GB USB
7 ml (Prediluted)  /  $315 +1 FREE 8GB USB
0.5 mL (Concentrate)  /  $415 +1 FREE 8GB USB
15 ml (Prediluted)  /  $535 +1 FREE 8GB USB
1 mL (Concentrate)  /  $600 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AMACRacemase, Monoclonal Antibody

 Also Known As   

AMACRacemase RMab

 Product Synonym Names    AMACRacemase RMab
 Product Gene Name   

anti-AMACRacemase antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 5; NC_000005.9 (33987091..34008220, complement). Location: 5p13
 OMIM    214950
 3D Structure    ModBase 3D Structure for Q9UHK6
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    13H4
 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    P504S/AMACR is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
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 Control    Prostatic Adenocarcinoma
 Localization    Cytoplasmic
 Reactivity Note    Paraffin, Frozen
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 Preparation and Storage    Store at 2 to 8 degree C in the dark.
 Other Notes    Small volumes of anti-AMACRacemase antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-AMACRacemase antibody

   AMACR (P504S) is an acronym for the protein alpha-methylacyl CoA racemase that helps to metabolize certain fatty acids within the body. AMACR has been recently described as a prostate cancer-specifi c gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids. Expression of AMACR protein is found in Prostatic Adenocarcinoma but not in benign prostatic tissue. It stains premalignant lesions of the prostate: High-Grade Prostatic Intraepithelial Neoplasia (PIN) and Atypical Adenomatous Hyperplasia. Several studies have suggested that AMACR can be used as a prostate cancer biomarker.High expression of AMACR (P504S) protein is usually found in Prostatic Adenocarcinoma but not in benign prostatic tissue by immunohistochemical staining in paraffin-embedded tissues. Using AMACR as a positive marker along with basal-cell staining (34betaE12 or p63) as a negative marker could help to confirm the diagnosis of small foci of Prostate Carcinoma on needle biopsies.
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 Dilution Information of anti-AMACRacemase antibody    anti-AMACRacemase antibody Dilution Information image
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 Immunohistochemistry (IHC) of anti-AMACRacemase antibody    anti-AMACRacemase antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for AMACRacemase. It may not necessarily be applicable to this product.
 NCBI GI #    13626118
 NCBI GeneID    23600
 NCBI Accession #    Q9UHK6 [Other Products]
 NCBI GenBank Nucleotide #    Q9UHK6 [Other Products]
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 UniProt Primary Accession #    Q9UHK6 [Other Products]
 UniProt Secondary Accession #    O43673; Q96GH1; Q9Y3Q1; A5YM47; B8Y916; B8Y918 [Other Products]
 UniProt Related Accession #    Q3KT79; Q53GV0; Q6VRU3; Q6VRU4; Q9UHK6 [Other Products]
 Molecular Weight    42,387 Da
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 NCBI Official Full Name    Alpha-methylacyl-CoA racemase
 NCBI Official Synonym Full Names    alpha-methylacyl-CoA racemase
 NCBI Official Symbol    AMACR [Similar Products]
 NCBI Official Synonym Symbols   
RM; RACE; CBAS4
[Similar Products]
 NCBI Protein Information    alpha-methylacyl-CoA racemase; OTTHUMP00000115916; OTTHUMP00000115917; OTTHUMP00000219978; OTTHUMP00000219979; OTTHUMP00000219980; 2-methylacyl-CoA racemase
 UniProt Protein Name    Alpha-methylacyl-CoA racemase
 UniProt Synonym Protein Names   
2-methylacyl-CoA racemase
 UniProt Gene Name    AMACR [Similar Products]
 UniProt Entry Name    AMACR_HUMAN
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 NCBI Summary for AMACRacemase    This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq]
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 UniProt Comments for AMACRacemase    Function: Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.

Catalytic activity: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA.

Pathway: Lipid metabolism; bile acid biosynthesis.Lipid metabolism; fatty acid metabolism.

Subcellular location: Peroxisome. Mitochondrion Ref.1.

Involvement in disease: Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) [

MIM:604489]. AMACRD results in elevated plasma concentrations of pristanic acid C27-bile-acid intermediates. It can be associated with polyneuropathy, retinitis pigmentosa, epilepsy. Ref.2Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4) [

MIM:214950]; also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile. Ref.2 Ref.11

Sequence similarities: Belongs to the CaiB/BaiF CoA-transferase family.

Sequence caution: The sequence ACL67853.1 differs from that shown. Reason: Aberrant splicing.The sequence ACL67854.1 differs from that shown. Reason: Aberrant splicing.The sequence CAB44062.1 differs from that shown. Reason: Frameshift at positions 62, 65 and 114.
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 Research Articles on AMACRacemase    1. A combination of high molecular weight cytokeratin and alpha-methylacyl CoA racemase is of great value in combating the morphologically suspicious cases and significantly increasing the diagnostic accuracy in prostate cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-AMACRacemase antibodyDiseases associated with anti-AMACRacemase antibody
 Products by Pathway  Pathway Diagram
 Beta-oxidation Of Pristanoyl-CoA Pathway antibodies  Beta-oxidation Of Pristanoyl-CoA Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Peroxisomal Lipid Metabolism Pathway antibodies  Peroxisomal Lipid Metabolism Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Peroxisome Pathway antibodies  Peroxisome Pathway Diagram
 Primary Bile Acid Biosynthesis Pathway antibodies  Primary Bile Acid Biosynthesis Pathway Diagram
 Primary Bile Acid Biosynthesis Pathway antibodies  Primary Bile Acid Biosynthesis Pathway Diagram
 Synthesis Of Bile Acids And Bile Salts Pathway antibodies  Synthesis Of Bile Acids And Bile Salts Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >212 publications with AMACRacemase and Neoplasms
 Prostatic Neoplasms Antibodies  >159 publications with AMACRacemase and Prostatic Neoplasms
 Carcinoma Antibodies  >140 publications with AMACRacemase and Carcinoma
 Adenocarcinoma Antibodies  >115 publications with AMACRacemase and Adenocarcinoma
 Prostatic Intraepithelial Neoplasia Antibodies  >39 publications with AMACRacemase and Prostatic Intraepithelial Neoplasia
 Urologic Neoplasms Antibodies  >32 publications with AMACRacemase and Urologic Neoplasms
 Kidney Neoplasms Antibodies  >26 publications with AMACRacemase and Kidney Neoplasms
 Colorectal Neoplasms Antibodies  >25 publications with AMACRacemase and Colorectal Neoplasms
 Kidney Diseases Antibodies  >24 publications with AMACRacemase and Kidney Diseases
 Adenoma Antibodies  >22 publications with AMACRacemase and Adenoma
Organs/Tissues associated with anti-AMACRacemase antibody
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >181 publications with AMACRacemase and Prostate
 Kidney Antibodies  >28 publications with AMACRacemase and Kidney
 Blood Antibodies  >23 publications with AMACRacemase and Blood
 Lung Antibodies  >11 publications with AMACRacemase and Lung
 Bladder Antibodies  >9 publications with AMACRacemase and Bladder
 Liver Antibodies  >8 publications with AMACRacemase and Liver
 Intestine Antibodies  >8 publications with AMACRacemase and Intestine
 Lymph Antibodies  >6 publications with AMACRacemase and Lymph
 Lymph Node Antibodies  >5 publications with AMACRacemase and Lymph Node
 Skin Antibodies  >5 publications with AMACRacemase and Skin
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