NP_037498
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
93,469 Da
NCBI Official Full Name
anaphase-promoting complex subunit 2
NCBI Official Synonym Full Names
anaphase promoting complex subunit 2
NCBI Official Synonym Symbols
NCBI Protein Information
anaphase-promoting complex subunit 2
UniProt Protein Name
Anaphase-promoting complex subunit 2
UniProt Synonym Protein Names
Cyclosome subunit 2
UniProt Synonym Gene Names
UniProt Entry Name
ANC2_HUMAN
NCBI Summary for ANAPC2
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. [provided by RefSeq, Jul 2008]
UniProt Comments for ANAPC2
APC2: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the cullin family. The APC/C is composed of at least 12 subunits. Interacts through the cullin domain with ANAPC11 and with UBCH10. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin conjugating system; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: nucleoplasm; anaphase-promoting complex; cytosol
Molecular Function: ubiquitin protein ligase binding
Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; positive regulation of axon extension; mitotic cell cycle spindle assembly checkpoint; positive regulation of synaptic plasticity; mitotic cell cycle; positive regulation of dendrite morphogenesis
Research Articles on ANAPC2
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Products associated with anti-ANAPC2 antibody
Pathways associated with anti-ANAPC2 antibody
Diseases associated with anti-ANAPC2 antibody
Organs/Tissues associated with anti-ANAPC2 antibody
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