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anti-APOH antibody :: Mouse APOLIPOPROTEIN H Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS214131
Testing Data
Unit / Price
2 mL  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

APOLIPOPROTEIN H (APOH), Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN APOLIPOPROTEIN H

 Product Gene Name   

anti-APOH antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    138700
 3D Structure    ModBase 3D Structure for P02749
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    ID2
 Host    Mouse
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 Specificity    This item recognises the human Apolipoprotein H molecule, also known as beta 2 glycoprotein 1.This protein is expressed by placental trophoblast cells at high levels. Although the normal physiological role is not known, the protein appears to act as a co-factor for the binding of autoantibodies to phospholipids to trophoblasts, which is a process involved in the pathogenesis of recurrent miscarriage (anti phospholipid syndrome).
 Form/Format    Tissue Culture Supernatant - liquid
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 Perservative Stabilisers    0.09% Sodium Azide
 Histology Positive Control Tissue    Placenta
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-APOH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-APOH antibody

   MBS214131 recognises the human Apolipoprotein H molecule, also known as beta 2 glycoprotein 1.This protein is expressed by placental trophoblast cells at high levels. Although the normal physiological role is not known, the protein appears to act as a co-factor for the binding of autoantibodies to phospholipids to trophoblasts, which is a process involved in the pathogenesis of recurrent miscarriage (anti phospholipid syndrome).
 Applications Tested/Suitable for anti-APOH antibody   

Immunohistology Frozen, Western Blot (WB)

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 Testing Data of anti-APOH antibody    Staining of an 8.6 week placenta stained with Mouse anti Human Apolipoprotein H
anti-APOH antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for APOH. It may not necessarily be applicable to this product.
 NCBI GI #    153266841
 NCBI GeneID    350
 NCBI Accession #    NP_000033.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000042.2 [Other Products]
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 UniProt Primary Accession #    P02749 [Other Products]
 UniProt Secondary Accession #    Q9UCN7; B2R9M3 [Other Products]
 UniProt Related Accession #    P02749 [Other Products]
 Molecular Weight    38,298 Da [Similar Products]
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 NCBI Official Full Name    beta-2-glycoprotein 1
 NCBI Official Synonym Full Names    apolipoprotein H (beta-2-glycoprotein I)
 NCBI Official Symbol    APOH [Similar Products]
 NCBI Official Synonym Symbols   
BG; B2G1; B2GP1
[Similar Products]
 NCBI Protein Information    beta-2-glycoprotein 1; APC inhibitor; B2GPI; activated protein C-binding protein; anticardiolipin cofactor; apo-H; beta(2)GPI
 UniProt Protein Name    Beta-2-glycoprotein 1
 UniProt Synonym Protein Names   
APC inhibitor; Activated protein C-binding protein; Anticardiolipin cofactor; Apolipoprotein H; Apo-H; Beta-2-glycoprotein I; B2GPI; Beta(2)GPI
 Protein Family    Beta-2-glycoprotein
 UniProt Gene Name    APOH [Similar Products]
 UniProt Synonym Gene Names    B2G1; Apo-H; B2GPI; Beta(2)GPI [Similar Products]
 UniProt Entry Name    APOH_HUMAN
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 NCBI Summary for APOH    Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]
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 UniProt Comments for APOH    APOH: Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

Protein type: Lipid-binding; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: extracellular matrix; extracellular space; chylomicron; cell surface

Molecular Function: heparin binding; identical protein binding; protein binding; phospholipid binding; glycoprotein binding; lipid binding

Biological Process: negative regulation of angiogenesis; negative regulation of myeloid cell apoptosis; triacylglycerol metabolic process; negative regulation of fibrinolysis; positive regulation of blood coagulation; negative regulation of endothelial cell proliferation; positive regulation of lipoprotein lipase activity; negative regulation of blood coagulation; triacylglycerol transport; blood coagulation, intrinsic pathway; plasminogen activation; regulation of fibrinolysis
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 Research Articles on APOH    1. Partial or complete removal of the carbohydrate chains uncover cryptic epitopes present in beta(2)GPI.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-APOH antibodyDiseases associated with anti-APOH antibody
 Reference Product  PubMed Publications
 APOC3 antibody  >4 publications with APOH and APOC3
 APOA2 antibody  >3 publications with APOH and APOA2
 AMBP antibody  >1 publications with APOH and AMBP
 SERPINC1 antibody  >1 publications with APOH and SERPINC1
 AHSG antibody  >1 publications with APOH and AHSG
 LDLR antibody  >1 publications with APOH and LDLR
 Disease Name  Pubmed Publications
 Autoimmune Diseases Antibodies  >11 publications with APOH and Autoimmune Diseases
 Brain Diseases Antibodies  >8 publications with APOH and Brain Diseases
 Liver Diseases Antibodies  >8 publications with APOH and Liver Diseases
 Immune System Diseases Antibodies  >8 publications with APOH and Immune System Diseases
 Inflammation Antibodies  >7 publications with APOH and Inflammation
 Heart Diseases Antibodies  >6 publications with APOH and Heart Diseases
 Hemorrhage Antibodies  >5 publications with APOH and Hemorrhage
 Liver Neoplasms Antibodies  >3 publications with APOH and Liver Neoplasms
 Hypertension Antibodies  >3 publications with APOH and Hypertension
 Kidney Diseases Antibodies  >2 publications with APOH and Kidney Diseases
Organs/Tissues associated with anti-APOH antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >49 publications with APOH and Blood
 Liver Antibodies  >25 publications with APOH and Liver
 Brain Antibodies  >5 publications with APOH and Brain
 Muscle Antibodies  >4 publications with APOH and Muscle
 Heart Antibodies  >4 publications with APOH and Heart
 Lung Antibodies  >3 publications with APOH and Lung
 Kidney Antibodies  >3 publications with APOH and Kidney
 Intestine Antibodies  >2 publications with APOH and Intestine
 Embryonic Tissue Antibodies  >1 publications with APOH and Embryonic Tissue
 Spleen Antibodies  >1 publications with APOH and Spleen
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