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| Product Name
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AQUAPORIN 4 (AQP4), Monoclonal Antibody
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| Also Known As
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MOUSE ANTI AQUAPORIN 4
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| OMIM
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600308
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| 3D Structure
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ModBase 3D Structure for P55087
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| Clonality
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Monoclonal
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| Isotype
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IgG1
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| Clone Number
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3D2
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| Host
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Mouse
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| Form/Format
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Purified
Purified IgG - liquid
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| Concentration
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IgG concentration 1.0 mg/ml (lot specific)
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| Perservative Stabilisers
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0.1% Sodium Azide
0.1% Bovine Serum Albumin
Preparation
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| Immunogen
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Synthetic peptide corresponding to amino acids 301-318 of rat aquaporin 4.
Histology Positive Control Tissue
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| Target Species
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Human
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| Preparation and Storage
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Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
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| Other Notes
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Small volumes of anti-AQP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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Mouse anti Aquaporin 4 antibody, clone 3D2 recognizes an epitope within the cytoplasmic domain of the water-specific channel aquaporin 4 (also known as AQP4). Aquaporin 4 is located in various tissues including the gastro-intestinal tract, kidney and brain.
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| Applications Tested/Suitable for anti-AQP4 antibody
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Immunohistology Frozen, ELISA (EIA), Immunoprecipitation (IP), Immunohistology Paraffin*, Western Blot (WB)
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| Application Notes for anti-AQP4 antibody
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Immunohistology - Frozen: Maximum Dilution: 1/100;
ELISA: Minimum Dilution: 1/1000; Maximum Dilution: 1/20000;
Immunoprecipitation: Minimum Dilution: 1/1000; Maximum Dilution: 1/10000;
Immunohistology - Paraffin: Maximum Dilution: 1/100; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
Western Blotting: Minimum Dilution: 1/1000; Maximum Dilution: 1/10000
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TOP
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| NCBI/Uniprot data below describe general gene information for AQP4. It may not necessarily be applicable to this product. |
| NCBI GI #
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4502181
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| NCBI GeneID
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361
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| NCBI Accession #
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NP_001641.1
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_001650.4
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[Other Products]
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| UniProt Primary Accession #
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P55087
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[Other Products]
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| UniProt Secondary Accession #
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P78564
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[Other Products]
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| UniProt Related Accession #
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P55087
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[Other Products]
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| Molecular Weight
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32,300 Da
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[Similar Products]
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TOP
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| NCBI Official Full Name
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aquaporin-4 isoform a
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| NCBI Official Synonym Full Names
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aquaporin 4
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| NCBI Official Symbol
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AQP4
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[Similar Products]
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| NCBI Official Synonym Symbols
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MIWC; HMIWC2
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[Similar Products]
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| NCBI Protein Information
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aquaporin-4; WCH4; aquaporin 4 isoform delta4; aquaporin type4; mercurial-insensitive water channel
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| UniProt Protein Name
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Aquaporin-4
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| UniProt Synonym Protein Names
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Mercurial-insensitive water channel; MIWC; WCH4
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| Protein Family
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Aquaporin
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| UniProt Gene Name
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AQP4
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[Similar Products]
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| UniProt Synonym Gene Names
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AQP-4; MIWC
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[Similar Products]
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| UniProt Entry Name
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AQP4_HUMAN
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| NCBI Summary for AQP4
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This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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| UniProt Comments for AQP4
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AQP4: a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The predominant aquaporin found in brain. Two alternatively spliced transcript variants have been described
Protein type: Transporter, aquaporin family; Membrane protein, multi-pass; Transporter; Channel, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18q11.2-q12.1
Cellular Component: protein complex; integral to plasma membrane; basolateral plasma membrane; T-tubule; cytoplasm; plasma membrane; intercellular junction; external side of plasma membrane
Molecular Function: water transporter activity; water channel activity; porin activity; glycerol channel activity
Biological Process: glycerol transport; cellular water homeostasis; water transport; carbon dioxide transport; response to glucocorticoid stimulus; female pregnancy; response to radiation; sensory perception of sound; hyperosmotic salinity response; transport; renal water homeostasis; multicellular organismal water homeostasis; transmembrane transport; protein homooligomerization
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TOP
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| Research Articles on AQP4
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1. Our results suggest that hyperosmotic stress markedly reduces AQP4 expression possibly through a proteasome ubiquitinylation-independent pathway.
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Products associated with anti-AQP4 antibody | Pathways associated with anti-AQP4 antibody |
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| Diseases associated with anti-AQP4 antibody | Organs/Tissues associated with anti-AQP4 antibody |
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Antibody 
