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anti-AQP4 antibody :: Mouse AQUAPORIN 4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS215504 anti-AQP4 antibody
Unit / Price
0.02 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

AQUAPORIN 4 (AQP4), Monoclonal Antibody

 Also Known As   

MOUSE ANTI AQUAPORIN 4

 Product Gene Name   

anti-AQP4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600308
 3D Structure    ModBase 3D Structure for P55087
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    3D2
 Host    Mouse
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    IgG concentration 1.0 mg/ml (lot specific)
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 Perservative Stabilisers    0.09% Sodium Azide
0.1% Bovine Serum Albumin
Preparation
 Immunogen    Synthetic peptide corresponding to amino acids 301-318 of rat aquaporin 4.
Histology Positive Control Tissue
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-AQP4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-AQP4 antibody

   Mouse anti Aquaporin 4 antibody, clone 3D2 recognizes an epitope within the cytoplasmic domain of the water-specific channel aquaporin 4 (also known as AQP4). Aquaporin 4 is located in various tissues including the gastro-intestinal tract, kidney and brain.
 Applications Tested/Suitable for anti-AQP4 antibody   

Immunohistology Frozen, Immunohistology Paraffin*

 Application Notes for anti-AQP4 antibody    Immunohistology - Frozen: Maximum Dilution: 1/100;
Immunohistology - Paraffin: Maximum Dilution: 1/100; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose.
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NCBI/Uniprot data below describe general gene information for AQP4. It may not necessarily be applicable to this product.
 NCBI GI #    4502181
 NCBI GeneID    361
 NCBI Accession #    NP_001641.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001650.4 [Other Products]
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 UniProt Primary Accession #    P55087 [Other Products]
 UniProt Secondary Accession #    P78564 [Other Products]
 UniProt Related Accession #    P55087 [Other Products]
 Molecular Weight    32,300 Da [Similar Products]
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 NCBI Official Full Name    aquaporin-4 isoform a
 NCBI Official Synonym Full Names    aquaporin 4
 NCBI Official Symbol    AQP4 [Similar Products]
 NCBI Official Synonym Symbols   
MIWC; HMIWC2
[Similar Products]
 NCBI Protein Information    aquaporin-4; WCH4; aquaporin 4 isoform delta4; aquaporin type4; mercurial-insensitive water channel
 UniProt Protein Name    Aquaporin-4
 UniProt Synonym Protein Names   
Mercurial-insensitive water channel; MIWC; WCH4
 Protein Family    Aquaporin
 UniProt Gene Name    AQP4 [Similar Products]
 UniProt Synonym Gene Names    AQP-4; MIWC [Similar Products]
 UniProt Entry Name    AQP4_HUMAN
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 NCBI Summary for AQP4    This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The encoded protein is the predominant aquaporin found in brain. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for AQP4    AQP4: a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. The predominant aquaporin found in brain. Two alternatively spliced transcript variants have been described

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, aquaporin family; Transporter; Channel, misc.

Chromosomal Location of Human Ortholog: 18q11.2-q12.1

Cellular Component: protein complex; basolateral plasma membrane; integral to plasma membrane; T-tubule; cytoplasm; plasma membrane; intercellular junction; external side of plasma membrane

Molecular Function: water transporter activity; water channel activity; porin activity; glycerol channel activity

Biological Process: glycerol transport; cellular water homeostasis; carbon dioxide transport; water transport; response to glucocorticoid stimulus; female pregnancy; response to radiation; sensory perception of sound; hyperosmotic salinity response; transport; renal water homeostasis; multicellular organismal water homeostasis; transmembrane transport; protein homooligomerization
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 Research Articles on AQP4    1. Our results suggest that hyperosmotic stress markedly reduces AQP4 expression possibly through a proteasome ubiquitinylation-independent pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AQP4 antibodyPathways associated with anti-AQP4 antibody
 Reference Product  PubMed Publications
 AQP2 antibody  >144 publications with AQP4 and AQP2
 GFAP antibody  >121 publications with AQP4 and GFAP
 KCNJ10 antibody  >43 publications with AQP4 and KCNJ10
 AQP11 antibody  >15 publications with AQP4 and AQP11
 IL6 antibody  >7 publications with AQP4 and IL6
 Products by Pathway  Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Passive Transport By Aquaporins Pathway antibodies  Passive Transport By Aquaporins Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway antibodies  Vasopressin Regulates Renal Water Homeostasis Via Aquaporins Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram
 Vasopressin-regulated Water Reabsorption Pathway antibodies  Vasopressin-regulated Water Reabsorption Pathway Diagram
Diseases associated with anti-AQP4 antibodyOrgans/Tissues associated with anti-AQP4 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >941 publications with AQP4 and Nervous System Diseases
 Neuromyelitis Optica Antibodies  >566 publications with AQP4 and Neuromyelitis Optica
 Brain Diseases Antibodies  >469 publications with AQP4 and Brain Diseases
 Edema Antibodies  >459 publications with AQP4 and Edema
 Brain Edema Antibodies  >392 publications with AQP4 and Brain Edema
 Disease Models, Animal Antibodies  >206 publications with AQP4 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >175 publications with AQP4 and Cardiovascular Diseases
 Inflammation Antibodies  >122 publications with AQP4 and Inflammation
 Necrosis Antibodies  >46 publications with AQP4 and Necrosis
 Kidney Diseases Antibodies  >39 publications with AQP4 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >974 publications with AQP4 and Brain
 Spinal Cord Antibodies  >284 publications with AQP4 and Spinal Cord
 Nerve Antibodies  >206 publications with AQP4 and Nerve
 Vascular Antibodies  >187 publications with AQP4 and Vascular
 Kidney Antibodies  >163 publications with AQP4 and Kidney
 Eye Antibodies  >137 publications with AQP4 and Eye
 Muscle Antibodies  >108 publications with AQP4 and Muscle
 Lung Antibodies  >66 publications with AQP4 and Lung
 Intestine Antibodies  >27 publications with AQP4 and Intestine
 Embryonic Tissue Antibodies  >25 publications with AQP4 and Embryonic Tissue
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