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anti-AIP antibody :: Mouse anti-Human, Mouse ARA9 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS604103 anti-AIP antibody
Unit / Price
0.1 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ARA9 (AIP), Monoclonal Antibody

 Also Known As   

ARA9 (XAP2, Ah Receptor Associated Protein, ARA9, AIP)

 Product Synonym Names    Anti -ARA9 (XAP2, Ah Receptor Associated Protein, ARA9, AIP)
 Product Gene Name   

anti-AIP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (67250505..67258579). Location: 11q13.3
 OMIM    102200
 3D Structure    ModBase 3D Structure for O00170
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    3C108
 Host    Mouse
 Species Reactivity    Human, Mouse
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 Specificity    Specific for ARA9 FKBP domain.
 Purity/Purification    Ascites
Ascities
 Form/Format    Supplied as a liquid.
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 Immunogen    Bacterially expressed human ARA9.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-AIP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-AIP antibody

   Ah receptor-associated protein (ARA9) is also known as AIP and XAP2. This protein displays structural similarity to the glucocorticoid receptor-associated immunophilin FKBP52. Although they share significant homology, they have distinct cellular roles and biochemical properties. ARA9 is known to affect the potency and efficacy of AHR agonists in the yeast Saccharomyces cerevisiae as well as having functional consequence on AHR signal transduction.
 Product Categories/Family for anti-AIP antibody    Antibodies; Abs to Transcription Factors
 Applications Tested/Suitable for anti-AIP antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-AIP antibody    Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000. Band is seen at 37kD, representing ARA9
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NCBI/Uniprot data below describe general gene information for AIP. It may not necessarily be applicable to this product.
 NCBI GI #    201860300
 NCBI GeneID    9049
 NCBI Accession #    NP_003968.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003977.2 [Other Products]
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 UniProt Primary Accession #    O00170 [Other Products]
 UniProt Secondary Accession #    Q2M3Q2; Q99606; A0SZW3; A0SZW4; A0SZW5; A0SZW6 [Other Products]
 UniProt Related Accession #    O00170 [Other Products]
 Molecular Weight    37,636 Da [Similar Products]
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 NCBI Official Full Name    AH receptor-interacting protein
 NCBI Official Synonym Full Names    aryl hydrocarbon receptor interacting protein
 NCBI Official Symbol    AIP [Similar Products]
 NCBI Official Synonym Symbols   
ARA9; XAP2; XAP-2; FKBP16; FKBP37; SMTPHN
[Similar Products]
 NCBI Protein Information    AH receptor-interacting protein; immunophilin homolog ARA9; HBV X-associated protein 2
 UniProt Protein Name    AH receptor-interacting protein
 UniProt Synonym Protein Names   
Aryl-hydrocarbon receptor-interacting protein; HBV X-associated protein 2; XAP-2; Immunophilin homolog ARA9
 Protein Family    AH receptor-interacting protein
 UniProt Gene Name    AIP [Similar Products]
 UniProt Synonym Gene Names    XAP2; AIP; XAP-2 [Similar Products]
 UniProt Entry Name    AIP_HUMAN
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 NCBI Summary for AIP    The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. [provided by RefSeq, Sep 2008]
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 UniProt Comments for AIP    AIP: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Defects in AIP are a cause of growth hormone-secreting pituitary adenoma (GHSPA); also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma. Defects in AIP are a cause of ACTH-secreting pituitary adenoma (ASPA); also known as pituitary Cushing disease. A pituary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. Defects in AIP are a cause of prolactin-secreting pituitary adenoma (PSPA); also known as prolactinoma. Prolactin-secreting pituitary adenoma is the most common type of hormonally active pituitary adenoma.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol

Molecular Function: signal transducer activity; protein binding; transcription coactivator activity; unfolded protein binding; transcription factor binding

Biological Process: protein maturation via protein folding; xenobiotic metabolic process; signal transduction; protein targeting to mitochondrion; negative regulation of cyclic-nucleotide phosphodiesterase activity

Disease: Pituitary Adenoma, Prolactin-secreting; Pituitary Adenoma, Acth-secreting; Pituitary Adenoma, Growth Hormone-secreting
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 Research Articles on AIP    1. C-terminal AIP mutations appear to only disrupt client-protein binding to the Calpha-7h, while chaperone binding remains unaffected, suggesting that failure of client-protein interaction with the Calpha-7h is sufficient to predispose to pituitary adenoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AIP antibodyPathways associated with anti-AIP antibody
 Reference Product  PubMed Publications
 AHR antibody  >25 publications with AIP and AHR
 ARNT antibody  >12 publications with AIP and ARNT
 RET antibody  >6 publications with AIP and RET
 TOMM20 antibody  >2 publications with AIP and TOMM20
 PDE4A antibody  >1 publications with AIP and PDE4A
 HSP90AA1 antibody  >1 publications with AIP and HSP90AA1
 Products by Pathway  Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
Diseases associated with anti-AIP antibodyOrgans/Tissues associated with anti-AIP antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >273 publications with AIP and Neoplasms
 Fibrosis Antibodies  >176 publications with AIP and Fibrosis
 Adenoma Antibodies  >99 publications with AIP and Adenoma
 Cardiovascular Diseases Antibodies  >86 publications with AIP and Cardiovascular Diseases
 Inflammation Antibodies  >81 publications with AIP and Inflammation
 Kidney Diseases Antibodies  >57 publications with AIP and Kidney Diseases
 Poisoning Antibodies  >35 publications with AIP and Poisoning
 Heart Diseases Antibodies  >34 publications with AIP and Heart Diseases
 Necrosis Antibodies  >32 publications with AIP and Necrosis
 Intestinal Diseases Antibodies  >31 publications with AIP and Intestinal Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >474 publications with AIP and Blood
 Pancreas Antibodies  >299 publications with AIP and Pancreas
 Brain Antibodies  >178 publications with AIP and Brain
 Liver Antibodies  >177 publications with AIP and Liver
 Lung Antibodies  >112 publications with AIP and Lung
 Muscle Antibodies  >75 publications with AIP and Muscle
 Kidney Antibodies  >75 publications with AIP and Kidney
 Heart Antibodies  >65 publications with AIP and Heart
 Salivary Gland Antibodies  >55 publications with AIP and Salivary Gland
 Vascular Antibodies  >46 publications with AIP and Vascular
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