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anti-ASGR1  antibody :: Rabbit anti-Human ASGR1  Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2544072
Unit / Price
0.06 mL  /  $215 +1 FREE 8GB USB
0.12 mL  /  $330 +1 FREE 8GB USB
0.2 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ASGR1 , Monoclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti Human ASGR1  Monoclonal Antibody

 Product Gene Name   

anti-ASGR1  antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M10058 mRNA
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 Clonality    Monoclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Immunogen    Recombinant Human ASGPR1 protein
 Buffer    0.2 mum filtered solution in PBS with 5% trehalose
 Calculated MW    32kDa
 Observed MW    48kDa
 Buffer    PBS with 0.05% sodium azide, 30% glycerol and 5% trehalose
 Produce    This antibody was obtained from a rabbit immunized with purified, recombinant Human ASGPR1
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ASGR1  antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ASGR1  antibody

   The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules such as asialoorosomucoid (ASOR). ASGPR belongs to the long-form subfamily of the C-type/Ca2+ dependent lectin family. It is a complex of two noncovalently-linked and highly homologous subunits, a major 42 kDa glycoprotein ASGPR1 (MHL-1) and a minor 51 kDa glycoprotein ASGR2 (MHL-2). ASGPR1 is synthesized as a type II transmembrane protein that contains a cytosolic N-terminal domain, a single transmembrane segment, and an extracellular domain which contains two important structural regions. The first is a stalk domain that contributes to noncovalent oligomerization, and the second is a Ca2+-dependent carbohydrate binding domain at the very C-terminus that is unusually stabilized by three ions. The research regarded that ASGPR1 could be targeted for anti- hepatitis B virus (HBV) drug development.
 Applications Tested/Suitable for anti-ASGR1  antibody   

Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-ASGR1  antibody    WB: 1:200-1:1000
IP: 1:250-1:1000
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 Western blot of anti-ASGR1  antibody    Western blot analysis of HepG2 cells using Rabbit anti Human ASGR1 Monoclonal Antibody at dilution of 1:200
anti-ASGR1  antibody Western blot image
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 IP of anti-ASGR1  antibody    IP Result of ASGR1 (IP: MBS2544072,2ug; Detection: MBS2544072 ?dilution of 1:200) with 0.5mg HepG2 ASGR1(A) Rabbit blank IgG(B) cells
anti-ASGR1  antibody IP image
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NCBI/Uniprot data below describe general gene information for ASGR1 . It may not necessarily be applicable to this product.
 NCBI GI #    308387363
 NCBI GeneID    432
 NCBI GenBank Nucleotide #    NM_001197216.2 [Other Products]
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 UniProt Secondary Accession #    I3L1X1 [Other Products]
 UniProt Related Accession #    P07306 [Other Products]
 Molecular Weight    29,144 Da
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 NCBI Official Full Name    asialoglycoprotein receptor 1 isoform b
 NCBI Official Synonym Full Names    asialoglycoprotein receptor 1
 NCBI Official Symbol    ASGR1 [Similar Products]
 NCBI Official Synonym Symbols   
HL-1; ASGPR; ASGPR1; CLEC4H1
[Similar Products]
 NCBI Protein Information    asialoglycoprotein receptor 1
 UniProt Protein Name    Asialoglycoprotein receptor 1
 UniProt Synonym Protein Names   
C-type lectin domain family 4 member H1; Hepatic lectin H1; HL-1
 UniProt Gene Name    ASGR1 [Similar Products]
 UniProt Synonym Gene Names    CLEC4H1; ASGP-R 1; ASGPR 1; HL-1 [Similar Products]
 UniProt Entry Name    ASGR1_HUMAN
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 NCBI Summary for ASGR1     This gene encodes a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the more abundant major subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
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 UniProt Comments for ASGR1     ASGR1: Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: integral to plasma membrane

Molecular Function: protein binding

Biological Process: receptor-mediated endocytosis
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 Research Articles on ASGR1     1. ASGR1 haploinsufficiency was associated with reduced levels of non-HDL cholesterol and a reduced risk of coronary artery disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ASGR1  antibodyPathways associated with anti-ASGR1  antibody
 Reference Product  PubMed Publications
 ST3GAL4 antibody  >1 publications with ASGR1  and ST3GAL4
 Products by Pathway  Pathway Diagram
 Asparagine N-linked Glycosylation Pathway antibodies  Asparagine N-linked Glycosylation Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Thyroid Hormone Synthesis Pathway antibodies  Thyroid Hormone Synthesis Pathway Diagram
 Thyroid Hormone Synthesis Pathway antibodies  Thyroid Hormone Synthesis Pathway Diagram
Diseases associated with anti-ASGR1  antibodyOrgans/Tissues associated with anti-ASGR1  antibody
 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >4 publications with ASGR1  and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >3 publications with ASGR1  and Liver Diseases
 Cardiovascular Diseases Antibodies  >2 publications with ASGR1  and Cardiovascular Diseases
 Hypertension Antibodies  >1 publications with ASGR1  and Hypertension
 Hemorrhage Antibodies  >1 publications with ASGR1  and Hemorrhage
 Heart Diseases Antibodies  >1 publications with ASGR1  and Heart Diseases
 Disease Models, Animal Antibodies  >1 publications with ASGR1  and Disease Models, Animal
 Fibrosis Antibodies  >1 publications with ASGR1  and Fibrosis
 Inflammation Antibodies  >1 publications with ASGR1  and Inflammation
 Congenital Abnormalities Antibodies  >1 publications with ASGR1  and Congenital Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >20 publications with ASGR1  and Liver
 Muscle Antibodies  >1 publications with ASGR1  and Muscle
 Embryonic Tissue Antibodies  >1 publications with ASGR1  and Embryonic Tissue
 Skin Antibodies  >1 publications with ASGR1  and Skin
 Testis Antibodies  >1 publications with ASGR1  and Testis
 Brain Antibodies  >1 publications with ASGR1  and Brain
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