AAH06152.1
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ASPSCR1 protein
NCBI Official Synonym Full Names
alveolar soft part sarcoma chromosome region, candidate 1
NCBI Official Synonym Symbols
TUG; ASPL; ASPS; RCC17; UBXD9; UBXN9; ASPCR1 [Similar Products]
NCBI Protein Information
tether containing UBX domain for GLUT4; UBX domain protein 9; UBX domain-containing protein 9; alveolar soft part sarcoma locus; renal cell carcinoma, papillary, 17; renal papillary cell carcinoma protein 17; renal cell carcinoma gene on chromosome 17; alveolar soft part sarcoma chromosomal region candidate gene 1 protein
UniProt Protein Name
Tether containing UBX domain for GLUT4
UniProt Synonym Protein Names
Alveolar soft part sarcoma chromosomal region candidate gene 1 protein; Alveolar soft part sarcoma locus; Renal papillary cell carcinoma protein 17; UBX domain-containing protein 9
UniProt Synonym Gene Names
UniProt Entry Name
ASPC1_HUMAN
NCBI Summary for ASPSCR1
The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2011]
UniProt Comments for ASPSCR1
ASPSCR1: Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Interacts with GLUT4. Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, peripheral; Vesicle; Oncoprotein
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: nucleoplasm; ER-Golgi intermediate compartment membrane; internal side of plasma membrane; extrinsic to membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; endomembrane system; vesicle membrane; cytosol
Molecular Function: protein binding
Biological Process: intracellular protein transport; regulation of glucose import; glucose homeostasis
Disease: Alveolar Soft Part Sarcoma
Research Articles on ASPSCR1
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-ASPSCR1 antibody
Diseases associated with anti-ASPSCR1 antibody
Organs/Tissues associated with anti-ASPSCR1 antibody
|