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anti-ASXL1 antibody :: Mouse anti-Human ASXL1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120126
Quality Control
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ASXL1, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse monoclonal antibody Anti-Human ASXL1

 Product Synonym Names    Homo sapiens additional sex combs like 1 (Drosophila) (ASXL1), mRNA; KIAA0978; MGC71111; MGC117280
 Product Gene Name   

anti-ASXL1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605039
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    2049C2a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-ASXL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ASXL1 antibody

   In Drosophila, the Additional sex combs (Asx) gene encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. Although the function of the protein encoded by this gene is not known, it does show some sequence similarity to the protein encoded by the Drosophila Asx gene. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-ASXL1 antibody   

Dot Blot (DB)

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 Quality Control of anti-ASXL1 antibody    Left: Western blot analysis of immunized recombinant protein, using anti-ASXL1 monoclonal antibody.
anti-ASXL1 antibody Quality Control image
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NCBI/Uniprot data below describe general gene information for ASXL1. It may not necessarily be applicable to this product.
 NCBI GI #    257195176
 NCBI GeneID    171023
 NCBI Accession #    NP_056153.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_015338 [Other Products]
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 UniProt Secondary Accession #    Q5JWS9; Q8IYY7; Q9H466; Q9NQF8; Q9UFJ0; Q9UFP8; Q9Y2I4; B2RP59 [Other Products]
 UniProt Related Accession #    Q8IXJ9 [Other Products]
 Molecular Weight    53,374 Da
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 NCBI Official Full Name    Homo sapiens additional sex combs like transcriptional regulator 1 (ASXL1), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    additional sex combs like transcriptional regulator 1
 NCBI Official Symbol    ASXL1 [Similar Products]
 NCBI Official Synonym Symbols   
MDS; BOPS
[Similar Products]
 NCBI Protein Information    putative Polycomb group protein ASXL1; additional sex combs like 1
 UniProt Protein Name    Putative Polycomb group protein ASXL1
 UniProt Synonym Protein Names   
Additional sex combs-like protein 1
 Protein Family    Putative Polycomb group protein
 UniProt Gene Name    ASXL1 [Similar Products]
 UniProt Entry Name    ASXL1_HUMAN
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 NCBI Summary for ASXL1    This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
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 UniProt Comments for ASXL1    ASXL1: Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Defects in ASXL1 are the cause of Bohring-Opitz syndrome (BOPS). A syndrome characterized by severe intrauterine growth retardation, poor feeding, profound mental retardation, trigonocephaly, prominent metopic suture, exophthalmos, nevus flammeus of the face, upslanting palpebral fissures, hirsutism, and flexion of the elbows and wrists with deviation of the wrists and metacarpophalangeal joints. Defects in ASXL1 are a cause of myelodysplastic syndrome (MDS). A heterogeneous group of closely related clonal hematopoietic disorders. All are characterized by a hypercellular or hypocellular bone marrow with impaired morphology and maturation, dysplasia of the myeloid, megakaryocytic and/or erythroid lineages, and peripheral blood cytopenias resulting from ineffective blood cell production. Included diseases are: refractory anemia (RA), refractory anemia with ringed sideroblasts (RARS), refractory anemia with excess blasts (RAEB), refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS); chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative disease. MDS is considered a premalignant condition in a subgroup of patients that often progresses to acute myeloid leukemia (AML). Belongs to the Asx family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription regulation

Chromosomal Location of Human Ortholog: 20q11

Cellular Component: nuclear chromatin

Molecular Function: peroxisome proliferator activated receptor binding; protein binding; DNA binding; retinoic acid receptor binding; metal ion binding; transcription coactivator activity; transcription corepressor activity

Biological Process: negative regulation of retinoic acid receptor signaling pathway; response to retinoic acid; transcription, DNA-dependent; positive regulation of retinoic acid receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of fat cell differentiation

Disease: Bohring-opitz Syndrome; Myelodysplastic Syndrome
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 Research Articles on ASXL1    1. The current study confirms the independent prognostic value of nonsense/frameshift ASXL1 mutations in chronic myelomonocytic leukemia and signifies its added value to the Mayo prognostic model.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-ASXL1 antibodyOrgans/Tissues associated with anti-ASXL1 antibody
 Disease Name  Pubmed Publications
 Anemia Antibodies  >31 publications with ASXL1 and Anemia
 Cell Transformation, Neoplastic Antibodies  >26 publications with ASXL1 and Cell Transformation, Neoplastic
 Congenital Abnormalities Antibodies  >8 publications with ASXL1 and Congenital Abnormalities
 Fibrosis Antibodies  >5 publications with ASXL1 and Fibrosis
 Disease Models, Animal Antibodies  >5 publications with ASXL1 and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >4 publications with ASXL1 and Neurobehavioral Manifestations
 Skin Diseases Antibodies  >3 publications with ASXL1 and Skin Diseases
 Bohring syndrome Antibodies  >3 publications with ASXL1 and Bohring syndrome
 Liver Diseases Antibodies  >2 publications with ASXL1 and Liver Diseases
 Anemia, Macrocytic Antibodies  >2 publications with ASXL1 and Anemia, Macrocytic
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >73 publications with ASXL1 and Blood
 Bone Antibodies  >49 publications with ASXL1 and Bone
 Bone Marrow Antibodies  >47 publications with ASXL1 and Bone Marrow
 Liver Antibodies  >3 publications with ASXL1 and Liver
 Lung Antibodies  >3 publications with ASXL1 and Lung
 Skin Antibodies  >2 publications with ASXL1 and Skin
 Embryonic Tissue Antibodies  >2 publications with ASXL1 and Embryonic Tissue
 Prostate Antibodies  >2 publications with ASXL1 and Prostate
 Heart Antibodies  >2 publications with ASXL1 and Heart
 Thymus Antibodies  >1 publications with ASXL1 and Thymus
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