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anti-ATF2 antibody :: Mouse anti-Human ATF2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120012
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATF2, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse monoclonal antibody Anti-Human ATF2

 Product Synonym Names    activating transcription factor 2 (ATF2); HB16; CREB2; TREB7; CRE-BP1; MGC111558
 Product Gene Name   

anti-ATF2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    123811
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    ATF25I062
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-ATF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ATF2 antibody

   This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-ATF2 antibody   

Dot Blot (DB), Immunoprecipitation (IP)

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 Quality Control of anti-ATF2 antibody    Western blot analysis of immunized recombinant protein, using anti-ATF2 monoclonal antibody.
anti-ATF2 antibody Quality Control image
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 Quality Control #2 of anti-ATF2 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-ATF2 antibody Quality Control #2 image
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 Immunoprecipitation (IP) of anti-ATF2 antibody    Immunoprecipitation: RIPA lysate of HeLa cells was incubated with anti-ATF2 mAb. [Lot No. ATF25I062-1]

Predicted molecular weight: 54 kDa
anti-ATF2 antibody Immunoprecipitation (IP) (IP) image
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NCBI/Uniprot data below describe general gene information for ATF2. It may not necessarily be applicable to this product.
 NCBI GI #    368711267
 NCBI GeneID    1386
 NCBI Accession #    NP_001871.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001880 [Other Products]
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 UniProt Secondary Accession #    Q13000; Q3B7B7; Q4ZFU9; Q53RY2; Q8TAR1; A1L3Z2; A4D7U4; A4D7U5; A4D7V1; D3DPE9; G8JLM5 [Other Products]
 UniProt Related Accession #    P15336 [Other Products]
 Molecular Weight    15,409 Da
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 NCBI Official Full Name    Homo sapiens activating transcription factor 2 (ATF2), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    activating transcription factor 2
 NCBI Official Symbol    ATF2 [Similar Products]
 NCBI Official Synonym Symbols   
HB16; CREB2; TREB7; CREB-2; CRE-BP1
[Similar Products]
 NCBI Protein Information    cyclic AMP-dependent transcription factor ATF-2; activating transcription factor 2 splice variant ATF2-var2; cAMP response element-binding protein CRE-BP1; cAMP responsive element binding protein 2, formerly; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; cyclic AMP-responsive element-binding protein 2; histone acetyltransferase ATF2
 UniProt Protein Name    Cyclic AMP-dependent transcription factor ATF-2
 UniProt Synonym Protein Names   
Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding protein 2; HB16; Histone acetyltransferase ATF2; cAMP response element-binding protein CRE-BP1
 Protein Family    Alcohol O-acetyltransferase
 UniProt Gene Name    ATF2 [Similar Products]
 UniProt Entry Name    ATF2_HUMAN
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 NCBI Summary for ATF2    This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene [provided by RefSeq, Jan 2014]
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 UniProt Comments for ATF2    ATF-2: a transcription factor that is a member of the leucine zipper family. Binds to the cAMP-responsive element (CRE). Forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. Also possesses histone acetyltransferase (HAT) activity that specifically acetylates histones H2B and H4 in vitro.

Protein type: C2H2-type zinc finger protein; Transcription factor; EC 2.3.1.48

Chromosomal Location of Human Ortholog: 2q32

Cellular Component: nucleoplasm; mitochondrial outer membrane; cytoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; histone acetyltransferase activity; protein heterodimerization activity; metal ion binding; cAMP response element binding protein binding; transcription coactivator activity; chromatin binding; protein kinase binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; fat cell differentiation; establishment and/or maintenance of chromatin architecture; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; response to osmotic stress; positive regulation of transforming growth factor-beta2 production; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; regulation of transcription factor activity; intra-S DNA damage checkpoint; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; histone acetylation; toll-like receptor 4 signaling pathway; response to DNA damage stimulus
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 Research Articles on ATF2    1. in human HCC tissues, SPTBN1 expression correlated negatively with expression levels of STAT3, ATF3, and CREB2; SMAD3 expression correlated negatively with STAT3 expression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ATF2 antibodyPathways associated with anti-ATF2 antibody
 Reference Product  PubMed Publications
 JUN antibody  >401 publications with ATF2 and JUN
 MAPK8 antibody  >23 publications with ATF2 and MAPK8
 ATM antibody  >9 publications with ATF2 and ATM
 MAPK14 antibody  >9 publications with ATF2 and MAPK14
 JDP2 antibody  >6 publications with ATF2 and JDP2
 RUVBL2 antibody  >1 publications with ATF2 and RUVBL2
 MAPK11 antibody  >1 publications with ATF2 and MAPK11
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of The AP-1 Family Of Transcription Factors Pathway antibodies  Activation Of The AP-1 Family Of Transcription Factors Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
 Amphetamine Addiction Pathway antibodies  Amphetamine Addiction Pathway Diagram
Diseases associated with anti-ATF2 antibodyOrgans/Tissues associated with anti-ATF2 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >73 publications with ATF2 and Necrosis
 Inflammation Antibodies  >49 publications with ATF2 and Inflammation
 Disease Models, Animal Antibodies  >34 publications with ATF2 and Disease Models, Animal
 Nervous System Diseases Antibodies  >33 publications with ATF2 and Nervous System Diseases
 Brain Diseases Antibodies  >27 publications with ATF2 and Brain Diseases
 Cardiovascular Diseases Antibodies  >26 publications with ATF2 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >26 publications with ATF2 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >20 publications with ATF2 and Neoplasms, Experimental
 Liver Diseases Antibodies  >20 publications with ATF2 and Liver Diseases
 Liver Neoplasms Antibodies  >17 publications with ATF2 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >85 publications with ATF2 and Blood
 Brain Antibodies  >79 publications with ATF2 and Brain
 Muscle Antibodies  >56 publications with ATF2 and Muscle
 Liver Antibodies  >40 publications with ATF2 and Liver
 Bone Antibodies  >39 publications with ATF2 and Bone
 Lung Antibodies  >39 publications with ATF2 and Lung
 Vascular Antibodies  >38 publications with ATF2 and Vascular
 Nerve Antibodies  >37 publications with ATF2 and Nerve
 Kidney Antibodies  >29 publications with ATF2 and Kidney
 Skin Antibodies  >26 publications with ATF2 and Skin
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