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anti-ATF6 antibody :: Mouse anti-Human ATF6 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS668021
Unit / Price
0.025 mg  /  $145 +1 FREE 8GB USB
0.1 mg  /  $290 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATF6, Monoclonal Antibody

★Popular Item★
 Also Known As   

ATF6 Monoclonal Antibody

 Product Gene Name   

anti-ATF6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605537
 3D Structure    ModBase 3D Structure for P18850
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 Clonality    Monoclonal
 Isotype    Mouse IgG1, Kappa
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    Protein G Chromatography
 Form/Format    Purified
25 ug in 50 uL PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
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 Immunogen    A partial recombinant ATF6 protein (amino acids 1-400) was used as the immunogen for this antibody
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 Preparation and Storage    Store antibody at 4C, stable for 6 months. For long-term storage, store at -20C. Avoid repeated freeze and thaw cycles.
 Other Notes    Small volumes of anti-ATF6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ATF6 antibody

   ATF6, also named as Cyclic AMP-dependent transcription factor ATF-6 alpha is a member of bZIP family, ATF subfamily. ATF6 forms homodimer and heterodimer with ATF6-beta. ATF6 acts by activating specific unfolded protein response target genes during endoplasmic reticulum stress. ATF6 is a ubiquitously expressed transcription factor located at endoplasmic reticulum (ER) membrane. During ER stress an approximately 50kDa fragment containing the N-terminal cytoplasmic domain is cleaved by proteolysis and is translocated into the nucleus. N-glycosylation may serve as a sensor for ER homeostasis. For the binding of ATF6 to ERSE, ESRE should first bind to another transcription factor called Nuclear Transcription Factor Y (NF-Y). ATF6 could also be involved in activation of transcription by interacting with serum response factor. ATF6 is a 74 kDa protein and is highly expressed in kidney, liver, colon and mammary gland.
 Product Categories/Family for anti-ATF6 antibody    Apoptosis
 Applications Tested/Suitable for anti-ATF6 antibody   

FACS, WB

 Application Notes for anti-ATF6 antibody    Western Blot analysis: 2-4 ug/mL
FACS: 0.5 ug/106 cells
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 Western Blot (WB) of anti-ATF6 antibody    Expression analysis of ATF6. Anti- ATF6 antibody (Clone: ABM1A40) was used at 2 ug/ml on K562 lysate.
anti-ATF6 antibody Western Blot (WB) (WB) image
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 Flow Cytometry of anti-ATF6 antibody    Intracellular staining of full length ATF6 plasmid and blank plasmid transfected HEK293 cells. 0.5 ug of anti-ATF6 antibody was used. Green represents blank plasmid, Red represents ATF6 expression plasmid. Goat anti-mouse PE was used as secondary antibody.
anti-ATF6 antibody Flow Cytometry (FC/FACS) image
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 Western Blot of anti-ATF6 antibody    Expression analysis of ATF6. Anti- ATF6 antibody (Clone ABM1A40) was used at 2 ug/ml on (1) Blank plasmid transfected HEK293 cells, (2) Partial length ATF6 plasmid transfected HEK293 cells and (3) Fulll length ATF6 plasmid transfected HEK293 cells.
anti-ATF6 antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for ATF6. It may not necessarily be applicable to this product.
 NCBI GI #    56786157
 NCBI GeneID    22926
 NCBI Accession #    NP_031374.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_007348.3 [Other Products]
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 UniProt Primary Accession #    P18850 [Other Products]
 UniProt Secondary Accession #    O15139; Q5VW62; Q6IPB5; Q9UEC9 [Other Products]
 UniProt Related Accession #    P18850 [Other Products]
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 NCBI Official Full Name    cyclic AMP-dependent transcription factor ATF-6 alpha
 NCBI Official Synonym Full Names    activating transcription factor 6
 NCBI Official Symbol    ATF6 [Similar Products]
 NCBI Official Synonym Symbols   
ATF6A
[Similar Products]
 NCBI Protein Information    cyclic AMP-dependent transcription factor ATF-6 alpha; cAMP-dependent transcription factor ATF-6 alpha
 UniProt Protein Name    Cyclic AMP-dependent transcription factor ATF-6 alpha
 UniProt Synonym Protein Names   
Activating transcription factor 6 alpha; ATF6-alpha
 Protein Family    Cyclic AMP-dependent transcription factor
 UniProt Gene Name    ATF6 [Similar Products]
 UniProt Synonym Gene Names    cAMP-dependent transcription factor ATF-6 alpha; ATF6-alpha [Similar Products]
 UniProt Entry Name    ATF6A_HUMAN
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 NCBI Summary for ATF6    This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
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 UniProt Comments for ATF6    ATF6A: Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. Belongs to the bZIP family. ATF subfamily.

Protein type: Transcription factor; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: Golgi membrane; nucleoplasm; Golgi apparatus; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to endoplasmic reticulum membrane; nuclear envelope; nucleus

Molecular Function: protein binding; protein heterodimerization activity; transcription coactivator activity; transcription factor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; transcription, DNA-dependent; protein folding; unfolded protein response; positive regulation of transcription of target genes involved in unfolded protein response; response to stress; signal transduction

Disease: Achromatopsia 7
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 Research Articles on ATF6    1. Data show that silver nanoparticles induce activating transcription factor-6 (ATF-6) degradation, leading to activation of the NLRP-3 inflammasome and pyroptosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ATF6 antibodyPathways associated with anti-ATF6 antibody
 Reference Product  PubMed Publications
 DDIT3 antibody  >218 publications with ATF6 and DDIT3
 XBP1 antibody  >183 publications with ATF6 and XBP1
 ATF4 antibody  >164 publications with ATF6 and ATF4
 ERN1 antibody  >57 publications with ATF6 and ERN1
 HSPA5 antibody  >33 publications with ATF6 and HSPA5
 YY1 antibody  >7 publications with ATF6 and YY1
 MBTPS2 antibody  >3 publications with ATF6 and MBTPS2
 WFS1 antibody  >3 publications with ATF6 and WFS1
 MAPK14 antibody  >2 publications with ATF6 and MAPK14
 Products by Pathway  Pathway Diagram
 ATF4 Activates Genes Pathway antibodies  ATF4 Activates Genes Pathway Diagram
 ATF6-alpha Activates Chaperone Genes Pathway antibodies  ATF6-alpha Activates Chaperone Genes Pathway Diagram
 ATF6-alpha Activates Chaperones Pathway antibodies  ATF6-alpha Activates Chaperones Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 PERK Regulates Gene Expression Pathway antibodies  PERK Regulates Gene Expression Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
Diseases associated with anti-ATF6 antibodyOrgans/Tissues associated with anti-ATF6 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >61 publications with ATF6 and Inflammation
 Liver Diseases Antibodies  >53 publications with ATF6 and Liver Diseases
 Brain Diseases Antibodies  >41 publications with ATF6 and Brain Diseases
 Necrosis Antibodies  >38 publications with ATF6 and Necrosis
 Heart Diseases Antibodies  >27 publications with ATF6 and Heart Diseases
 Insulin Resistance Antibodies  >23 publications with ATF6 and Insulin Resistance
 Lung Diseases Antibodies  >22 publications with ATF6 and Lung Diseases
 Fibrosis Antibodies  >19 publications with ATF6 and Fibrosis
 Atherosclerosis Antibodies  >16 publications with ATF6 and Atherosclerosis
 Fatty Liver Antibodies  >15 publications with ATF6 and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >93 publications with ATF6 and Liver
 Brain Antibodies  >74 publications with ATF6 and Brain
 Blood Antibodies  >72 publications with ATF6 and Blood
 Muscle Antibodies  >64 publications with ATF6 and Muscle
 Heart Antibodies  >52 publications with ATF6 and Heart
 Vascular Antibodies  >50 publications with ATF6 and Vascular
 Pancreas Antibodies  >39 publications with ATF6 and Pancreas
 Lung Antibodies  >30 publications with ATF6 and Lung
 Bone Antibodies  >28 publications with ATF6 and Bone
 Eye Antibodies  >27 publications with ATF6 and Eye
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