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anti-ATM antibody :: Mouse ATM Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS190053 anti-ATM antibody
Unit / Price
0.1 mg  /  $410 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATM, Monoclonal Antibody

 Also Known As   

ATM Monoclonal Antibody

 Product Synonym Names    Anti-ATM; ATM
 Product Gene Name   

anti-ATM antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (108093559..108239826). Location: 11q22-q23
 OMIM    208900
 3D Structure    ModBase 3D Structure for Q13315
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 Clonality    Monoclonal
 Isotype    IgG1 kappa
 Host    Mouse
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 Specificity    Anti-ATM [Murine MAb recognizes full-length ATM, a 370 kDa nuclear phosphoprotein associated with cell cycle regulation and response to DNA repair.]
This antibody recognizes full-length ATM, a 370 kD nuclear phosphoprotein, which is involved in the autooal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation and response to DNA repair. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases). Its usefulness to monitor altered ATM expression in cancer is under active investigations.
 Form/Format    100 ug Protein G purified antibody in PBS, pH 7.4
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 Antigen    GST fusion protein expressedin E. coli corresponding to aa 2577-3056 of full-length ATM.
 Stabilizer    None
 Preservatives    None. Available on request.
 Dilutions Instructions    Dilute in PBS or medium which is identical to that used in the assay system.
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 Preparation and Storage    This antibody is stable for at least one (1) year at -70 degree C. Avoid multiple freeze thaw cycles.
 Other Notes    Small volumes of anti-ATM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ATM antibody    Cancer Research Products
 Applications Tested/Suitable for anti-ATM antibody   

Immunoblot, Immunoprecipitation

 Application Notes for anti-ATM antibody    Immunoblotting: use at 1-10 ug/ml.
Immunoprecipitation: use at 1-10 ug/ml.
Positive controls: Raji or Akata cells.
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NCBI/Uniprot data below describe general gene information for ATM. It may not necessarily be applicable to this product.
 NCBI GI #    2304971
 NCBI GeneID    472
 NCBI Accession #    AAB65827.1 [Other Products]
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 UniProt Primary Accession #    Q13315 [Other Products]
 UniProt Secondary Accession #    O15429; Q12758; Q16551; Q93007; Q9NP02; Q9UCX7; B2RNX5 [Other Products]
 UniProt Related Accession #    Q13315; Q59GH6; Q68DE6; Q6P7P1; Q8TDS0; Q96QM9 [Other Products]
 Molecular Weight    350,714 Da [Similar Products]
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 NCBI Official Full Name    ATM
 NCBI Official Synonym Full Names    ataxia telangiectasia mutated
 NCBI Official Symbol    ATM [Similar Products]
 NCBI Official Synonym Symbols   
AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1; MGC74674; DKFZp781A0353
[Similar Products]
 NCBI Protein Information    serine-protein kinase ATM; AT mutated; A-T mutated; OTTHUMP00000232981; TEL1, telomere maintenance 1, homolog
 UniProt Protein Name    Serine-protein kinase ATM
 UniProt Synonym Protein Names   
Ataxia telangiectasia mutated
 Protein Family    ATM interactor
 UniProt Gene Name    ATM [Similar Products]
 UniProt Entry Name    ATM_HUMAN
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 NCBI Summary for ATM    The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq]
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 UniProt Comments for ATM    ATM: an atypical kinase of the PIKK family. Regulates cell cycle checkpoints and DNA repair . May function as a tumor suppressor. Activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Involved in the activation of ABL1 and SAPK. Binds DNA ends and is part of the BRCA1- associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. DNA damage promotes association with RAD17. LOF mutations associated with ataxia telangiectasia, causing progressive loss of motor control (ataxia), dilation of superficial blood vessels (telangiectasia), cancer and immune deficiency. Approximately 30% of cases develop tumors, mostly lymphomas and leukemias, due to defects in DNA damage repair. Somatic mutations seen in leukemias and lymphomas.

Protein type: Kinase, protein; DNA repair, damage; Tumor suppressor; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; EC 2.7.11.1; ATYPICAL group; PIKK family

Chromosomal Location of Human Ortholog: 11q22-q23

Cellular Component: nucleoplasm; chromosome, telomeric region; cytoplasmic membrane-bound vesicle; spindle

Molecular Function: protein dimerization activity; protein serine/threonine kinase activity; protein binding; DNA binding; 1-phosphatidylinositol-3-kinase activity; protein complex binding; protein N-terminus binding; DNA-dependent protein kinase activity; histone serine kinase activity; ATP binding

Biological Process: lipoprotein catabolic process; DNA damage induced protein phosphorylation; positive regulation of apoptosis; heart development; protein amino acid autophosphorylation; pre-B cell allelic exclusion; negative regulation of B cell proliferation; signal transduction; protein amino acid phosphorylation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; double-strand break repair; positive regulation of neuron apoptosis; mitotic cell cycle spindle assembly checkpoint; cell cycle arrest; telomere maintenance; somitogenesis; V(D)J recombination; DNA repair; double-strand break repair via homologous recombination; neuron apoptosis; peptidyl-serine phosphorylation; DNA damage response, signal transduction resulting in induction of apoptosis; meiotic recombination; response to hypoxia; positive regulation of DNA damage response, signal transduction by p53 class mediator; response to ionizing radiation; brain development; response to DNA damage stimulus; oocyte development

Disease: Ataxia-telangiectasia; Breast Cancer
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Product References and Citations for anti-ATM antibody

   Chen, G and EY-HP Lee (1996) J Biol Chem 271: 33693-33697.
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 Research Articles on ATM    1. Study of eight cases of human ataxia-telangiectasia finds evidence for residual ATM protein in brain from seven patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ATM antibodyPathways associated with anti-ATM antibody
 Reference Product  PubMed Publications
 H2AFX antibody  >251 publications with ATM and H2AFX
 PRKDC antibody  >230 publications with ATM and PRKDC
 TP53 antibody  >223 publications with ATM and TP53
 NBN antibody  >183 publications with ATM and NBN
 MRE11A antibody  >139 publications with ATM and MRE11A
 RAD51 antibody  >132 publications with ATM and RAD51
 MDM2 antibody  >130 publications with ATM and MDM2
 MDC1 antibody  >94 publications with ATM and MDC1
 TP53BP1 antibody  >75 publications with ATM and TP53BP1
 CHEK2 antibody  >59 publications with ATM and CHEK2
 Products by Pathway  Pathway Diagram
 ATM Mediated Phosphorylation Of Repair Proteins Pathway antibodies  ATM Mediated Phosphorylation Of Repair Proteins Pathway Diagram
 ATM Mediated Response To DNA Double-strand Break Pathway antibodies  ATM Mediated Response To DNA Double-strand Break Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Autodegradation Of The E3 Ubiquitin Ligase COP1 Pathway antibodies  Autodegradation Of The E3 Ubiquitin Ligase COP1 Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 Canonical NF-kappaB Pathway antibodies  Canonical NF-kappaB Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
Diseases associated with anti-ATM antibodyOrgans/Tissues associated with anti-ATM antibody
 Disease Name  Pubmed Publications
 Ataxia Telangiectasia Antibodies  >2641 publications with ATM and Ataxia Telangiectasia
 Neoplasms Antibodies  >1346 publications with ATM and Neoplasms
 Skin Diseases Antibodies  >337 publications with ATM and Skin Diseases
 Breast Neoplasms Antibodies  >312 publications with ATM and Breast Neoplasms
 Leukemia Antibodies  >294 publications with ATM and Leukemia
 Carcinoma Antibodies  >244 publications with ATM and Carcinoma
 Myocardial Ischemia Antibodies  >222 publications with ATM and Myocardial Ischemia
 Lymphoma Antibodies  >196 publications with ATM and Lymphoma
 Drug Toxicity Antibodies  >174 publications with ATM and Drug Toxicity
 Lung Diseases Antibodies  >128 publications with ATM and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1053 publications with ATM and Blood
 Brain Antibodies  >585 publications with ATM and Brain
 Vascular Antibodies  >419 publications with ATM and Vascular
 Lung Antibodies  >305 publications with ATM and Lung
 Heart Antibodies  >217 publications with ATM and Heart
 Muscle Antibodies  >193 publications with ATM and Muscle
 Bone Antibodies  >157 publications with ATM and Bone
 Skin Antibodies  >143 publications with ATM and Skin
 Kidney Antibodies  >140 publications with ATM and Kidney
 Liver Antibodies  >131 publications with ATM and Liver
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