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anti-ATP2A2 antibody :: Mouse ATPase 2, Ca2+ Transporting, Sarcoplasmic Endoplasmic Reticulum Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS604309 anti-ATP2A2 antibody
Unit / Price
0.1 mL  /  $870 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATPase 2, Ca2+ Transporting, Sarcoplasmic Endoplasmic Reticulum (ATP2A2), Monoclonal Antibody

 Also Known As   

ATPase 2, Ca2+ Transporting, Sarcoplasmic Endoplasmic Reticulum (SERCA2)

 Product Synonym Names    Anti -ATPase 2, Ca2+ Transporting, Sarcoplasmic Endoplasmic Reticulum (SERCA2)
 Product Gene Name   

anti-ATP2A2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 14; NC_010456.3 (35115998..35185461). Location: 14; 14
 3D Structure    ModBase 3D Structure for P11607
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    6D141
 Host    Mouse
 Species Reactivity    Bovine, Canine, Human, Porcine, Rat
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 Specificity    Recognizes canine SERCA2a (sarcoplasmic/endoplasmic reticulum calcium ATPase 2a) and SERCA2b isoforms. Species crossreactivity: human, rat, porcine, bovine, rat. Does not crossreact with frog SERCA2 ATPase.
 Purity/Purification    Ascites
Ascites
 Form/Format    Supplied as a liquid in PBS, 0.05% sodium azide.
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 Immunogen    Purified canine cardiac sarcoplasmic reticulum.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-ATP2A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ATP2A2 antibody

   ATP dependent calcium pumps are responsible, in part, for the maintenance of low cytoplasmic free calcium concentrations. The ATP pumps that reside in intracellular organelles are encoded by a family of structurally related enzymes, termed the sarcoplasmic or endoplasmic reticulum calcium (SERCA) ATPases. The SERCA1 gene is exclusively expressed in type II (fast) skeletal muscle. The SERCA2 gene is subject to tissue dependent processing which is responsible for the generation of SERCA2a muscle-specific form expressed in type I (slow) skeletal, cardiac and smooth muscle and the SERCA2b isoform expressed in all cell types. The SERCA3 gene is not as well characterized and is found in non-muscle cells.
 Product Categories/Family for anti-ATP2A2 antibody    Antibodies; Abs to Enzymes, ATPase
 Applications Tested/Suitable for anti-ATP2A2 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

 Application Notes for anti-ATP2A2 antibody    Suitable for use in Immunocytochemistry, Immunohistochemistry and Western Blot.
Dilution: Immunohistochemistry (frozen sections): 1:500
Western Blot: 1:2500 Detects a band of ~110kD
Note: For detection of rat SERCA2 ATPase use A4000-93A.
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NCBI/Uniprot data below describe general gene information for ATP2A2. It may not necessarily be applicable to this product.
 NCBI GI #    47523128
 NCBI GeneID    396875
 NCBI Accession #    NP_999030.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_213865.1 [Other Products]
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 UniProt Primary Accession #    P11607 [Other Products]
 UniProt Secondary Accession #    P11606 [Other Products]
 UniProt Related Accession #    P11607 [Other Products]
 Molecular Weight    114,792 Da [Similar Products]
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 NCBI Official Full Name    sarcoplasmic/endoplasmic reticulum calcium ATPase 2
 NCBI Official Symbol    ATP2A2 [Similar Products]
 NCBI Official Synonym Symbols   
ATP2; SERCA2
[Similar Products]
 NCBI Protein Information    sarcoplasmic/endoplasmic reticulum calcium ATPase 2; calcium pump 2; SR Ca(2+)-ATPase 2; Ca(2+)-transport ATPase class 3; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarcoplasmic/endoplasmic-reticulum Ca(2+) pump gene 2; calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform
 UniProt Protein Name    Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
 UniProt Synonym Protein Names   
Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase
 Protein Family    Sarcoplasmic/endoplasmic reticulum calcium ATPase
 UniProt Gene Name    ATP2A2 [Similar Products]
 UniProt Entry Name    AT2A2_PIG
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 UniProt Comments for ATP2A2    Function: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle

Catalytic activity: ATP + H2O + Ca2+(Cis) = ADP + phosphate + Ca2+(Trans).

Enzyme regulation: Reversibly inhibited by phospholamban (PLN) at low calcium concentrations. Dephosphorylated PLN decreases the apparent affinity of the ATPase for calcium. This inhibition is regulated by the phosphorylation of PLN

Subunit structure: Associated with phospholamban (PLN)

By similarity. Isoform SERCA2B interacts with TRAM2 (via C-terminus). Interacts with HAX1

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.

Tissue specificity: Isoform SERCA2A is highly expressed in heart and slow twitch skeletal muscle. Isoform SERCA2B is widely expressed. Ref.3

Post-translational modification: Nitrated under oxidative stress. Nitration on the two tyrosine residues inhibits catalytic activity

Sequence similarities: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. [View classification]
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 Research Articles on ATP2A2    1. overexpression of SERCA2a by in vivo rAAV1-mediated intracoronary gene transfer preserved systolic function, potentially prevented diastolic dysfunction, and improved ventricular remodeling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ATP2A2 antibodyDiseases associated with anti-ATP2A2 antibody
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Pancreatic Secretion Pathway antibodies  Pancreatic Secretion Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >129 publications with ATP2A2 and Cardiovascular Diseases
 Heart Diseases Antibodies  >118 publications with ATP2A2 and Heart Diseases
 Genetic Diseases, Inborn Antibodies  >98 publications with ATP2A2 and Genetic Diseases, Inborn
 Darier Disease Antibodies  >96 publications with ATP2A2 and Darier Disease
 ACROKERATOSIS VERRUCIFORMIS Antibodies  >96 publications with ATP2A2 and ACROKERATOSIS VERRUCIFORMIS
 Heart Failure Antibodies  >75 publications with ATP2A2 and Heart Failure
 Hypertrophy Antibodies  >63 publications with ATP2A2 and Hypertrophy
 Cardiomegaly Antibodies  >41 publications with ATP2A2 and Cardiomegaly
 Cardiomyopathies Antibodies  >36 publications with ATP2A2 and Cardiomyopathies
 Ventricular Dysfunction, Left Antibodies  >32 publications with ATP2A2 and Ventricular Dysfunction, Left
Organs/Tissues associated with anti-ATP2A2 antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >209 publications with ATP2A2 and Muscle
 Heart Antibodies  >193 publications with ATP2A2 and Heart
 Skin Antibodies  >64 publications with ATP2A2 and Skin
 Blood Antibodies  >58 publications with ATP2A2 and Blood
 Brain Antibodies  >14 publications with ATP2A2 and Brain
 Thyroid Antibodies  >13 publications with ATP2A2 and Thyroid
 Embryonic Tissue Antibodies  >10 publications with ATP2A2 and Embryonic Tissue
 Lung Antibodies  >10 publications with ATP2A2 and Lung
 Kidney Antibodies  >9 publications with ATP2A2 and Kidney
 Eye Antibodies  >4 publications with ATP2A2 and Eye
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