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anti-ATP6AP1 antibody :: Mouse anti-Human ATPase H+ Transporting Lysosomal Accessory Protein 1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS631437 anti-ATP6AP1 antibody
Unit / Price
0.1 mg  /  $580 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ATPase H+ Transporting Lysosomal Accessory Protein 1 (ATP6AP1), Monoclonal Antibody

 Also Known As   

ATPase H+ Transporting Lysosomal Accessory Protein 1 (ATP6AP1, 16A, Ac45, ATPase H+ Transporting Lysosomal (Vacuolar Proton Pump) Subunit 1, ATP6S1, ATPase H+ Transporting Lysosomal Interacting Protein 1, ATP6IP1, CF2, H-ATPase Subunit, MGC129781, Protein

 Product Synonym Names    Anti -ATPase H+ Transporting Lysosomal Accessory Protein 1 (ATP6AP1, 16A, Ac45, ATPase H+ Transporting Lysosomal (Vacuolar Proton Pump) Subunit 1, ATP6S1, ATPase H+ Transporting Lysosomal Interacting Protein 1, ATP6IP1, CF2, H-ATPase Subunit, MGC129781, Protein
 Product Gene Name   

anti-ATP6AP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: X; NC_000023.10 (153656978..153664862). Location: Xq28
 OMIM    300197
 3D Structure    ModBase 3D Structure for Q15904
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    10B237
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human ATP6AP1.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2. No preservative added (Azide free).
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 Immunogen    Partial recombinant protein corresponding to a portion of aa51-151 of human ATP6AP1 (NP_001174), with GST tag. MW of GST tag alone is 26kD.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-ATP6AP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ATP6AP1 antibody

   This gene encodes a component of a multisubunit enzyme (1mD MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. [provided by RefSeq]
 Product Categories/Family for anti-ATP6AP1 antibody    Antibodies; Abs to Enzymes, Synthase
 Applications Tested/Suitable for anti-ATP6AP1 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-ATP6AP1 antibody    Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:500-1:1000
ELISA: 3ng/ml-1ug/ml
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NCBI/Uniprot data below describe general gene information for ATP6AP1. It may not necessarily be applicable to this product.
 NCBI GI #    119593120
 NCBI GeneID    537
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 UniProt Primary Accession #    Q15904 [Other Products]
 UniProt Secondary Accession #    A6ZKI4 [Other Products]
 UniProt Related Accession #    Q15904; Q8NBT4; Q8NF19; Q9H0C7 [Other Products]
 Molecular Weight    52,026 Da [Similar Products]
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 NCBI Official Full Name    ATPase, H+ transporting, lysosomal accessory protein 1, isoform CRA_c
 NCBI Official Synonym Full Names    ATPase, H+ transporting, lysosomal accessory protein 1
 NCBI Official Symbol    ATP6AP1 [Similar Products]
 NCBI Official Synonym Symbols   
16A; CF2; Ac45; XAP3; XAP-3; ATP6S1; VATPS1; ATP6IP1; MGC129781
[Similar Products]
 NCBI Protein Information    V-type proton ATPase subunit S1; protein XAP-3; H-ATPase subunit; OTTHUMP00000032115; OTTHUMP00000196463; V-ATPase subunit S1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; vacuolar proton pump subunit S1; ATPase, H+ transporting, lysosomal interacting protein 1; ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1
 UniProt Protein Name    V-type proton ATPase subunit S1
 UniProt Synonym Protein Names   
Protein XAP-3; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; Vacuolar proton pump subunit S1
 Protein Family    V-type proton ATPase
 UniProt Gene Name    ATP6AP1 [Similar Products]
 UniProt Synonym Gene Names    ATP6IP1; ATP6S1; VATPS1; XAP3 [Similar Products]
 UniProt Entry Name    VAS1_HUMAN
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 NCBI Summary for ATP6AP1    This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. [provided by RefSeq]
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 UniProt Comments for ATP6AP1    ATP6AP1: Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the vacuolar ATPase subunit S1 family.

Protein type: Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Hydrolase; Transporter; EC 3.6.3.14

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: vacuolar membrane; integral to membrane; endosome membrane; proton-transporting two-sector ATPase complex

Molecular Function: transporter activity; hydrogen ion transporting ATP synthase activity, rotational mechanism; hydrogen ion transporting ATPase activity, rotational mechanism; ATP binding; Rab GTPase binding

Biological Process: positive regulation of osteoblast differentiation; proton transport; cellular iron ion homeostasis; pH reduction; ATP hydrolysis coupled proton transport; insulin receptor signaling pathway; transferrin transport; positive regulation of bone resorption; transmembrane transport; positive regulation of exocytosis; establishment of organelle localization
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 Research Articles on ATP6AP1    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ATP6AP1 antibodyDiseases associated with anti-ATP6AP1 antibody
 Products by Pathway  Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram
 Disease Name  Pubmed Publications
 Bone Resorption Antibodies  >8 publications with ATP6AP1 and Bone Resorption
 Bone Diseases, Developmental Antibodies  >6 publications with ATP6AP1 and Bone Diseases, Developmental
 Osteoporosis Antibodies  >3 publications with ATP6AP1 and Osteoporosis
 Retinal Degeneration Antibodies  >2 publications with ATP6AP1 and Retinal Degeneration
 Breast Neoplasms Antibodies  >1 publications with ATP6AP1 and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >1 publications with ATP6AP1 and Ovarian Neoplasms
 Adenoma Antibodies  >1 publications with ATP6AP1 and Adenoma
 Pancreatic Neoplasms Antibodies  >1 publications with ATP6AP1 and Pancreatic Neoplasms
 Fetal Diseases Antibodies  >1 publications with ATP6AP1 and Fetal Diseases
 Ovarian Diseases Antibodies  >1 publications with ATP6AP1 and Ovarian Diseases
Organs/Tissues associated with anti-ATP6AP1 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >8 publications with ATP6AP1 and Bone
 Blood Antibodies  >4 publications with ATP6AP1 and Blood
 Eye Antibodies  >3 publications with ATP6AP1 and Eye
 Nerve Antibodies  >3 publications with ATP6AP1 and Nerve
 Bone Marrow Antibodies  >2 publications with ATP6AP1 and Bone Marrow
 Embryonic Tissue Antibodies  >2 publications with ATP6AP1 and Embryonic Tissue
 Liver Antibodies  >2 publications with ATP6AP1 and Liver
 Pancreas Antibodies  >2 publications with ATP6AP1 and Pancreas
 Kidney Antibodies  >2 publications with ATP6AP1 and Kidney
 Brain Antibodies  >2 publications with ATP6AP1 and Brain
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