NP_001186225.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
ATP-citrate synthase isoform 1
NCBI Official Synonym Full Names
ATP citrate lyase
NCBI Protein Information
ATP-citrate synthase; citrate cleavage enzyme; ATP-citrate (pro-S-)-lyase
UniProt Protein Name
ATP-citrate synthase
UniProt Synonym Protein Names
ATP-citrate (pro-S-)-lyase; Citrate cleavage enzyme
UniProt Entry Name
ACLY_MOUSE
UniProt Comments for Acly
ACLY: ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. Homotetramer. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lyase; Transferase; EC 2.3.3.8; Carbohydrate Metabolism - citrate (TCA) cycle
Cellular Component: nucleoplasm; membrane; mitochondrion; cytoplasm; plasma membrane; intracellular
Molecular Function: transferase activity; protein binding; transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer; ATP citrate synthase activity; metal ion binding; nucleotide binding; succinate-CoA ligase (ADP-forming) activity; cofactor binding; catalytic activity; ATP binding
Biological Process: acetyl-CoA metabolic process; metabolic process; lipid biosynthetic process; acetyl-CoA biosynthetic process; citrate metabolic process; cellular carbohydrate metabolic process; lipid metabolic process; fatty acid biosynthetic process
Research Articles on Acly
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Pathways associated with anti-Acly antibody
Diseases associated with anti-Acly antibody
Organs/Tissues associated with anti-Acly antibody
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