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anti-ACTA2 antibody :: Mouse Actin, alpha, Smooth Muscle Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS633258 anti-ACTA2 antibody
Unit / Price
100 Tests  /  $695 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Actin, alpha, Smooth Muscle (ACTA2), Monoclonal Antibody

★Popular Item★
 Also Known As   

Actin, alpha, Smooth Muscle (PE)

 Product Synonym Names    Anti -Actin, alpha, Smooth Muscle (PE)
 Product Gene Name   

anti-ACTA2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_000010.10 (90694831..90751147, complement). Location: 10q23.3
 OMIM    102620
 3D Structure    ModBase 3D Structure for P62736
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    9H15
 Host    Mouse
 Species Reactivity    Bovine, Canine, Chicken, Frog, Goat, Guinea Pig, Human, Mouse, Rabbit, Rat, Sheep
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 Specificity    Recognizes human alpha-Smooth Muscle Actin. Species Crossreactivity: bovine, chicken, frog, goat, guinea pig, mouse, rabbit, rat, canine, sheep and snake.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography
 Form/Format    Supplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with R-Phycoerythrin (PE).
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 Immunogen    Synthetic decapeptide corresponding to the N-terminal residues of human alpha-Smooth Muscle Actin.
 Hybridoma    Fusion of a mouse myeloma with B cells obtained from a rat immunized with a synthetic decapeptide from the N-terminal of Alpha-Smooth Muscle Actin.

Storage and Stability:
Maybe stored at 4 degree C before opening. DO NOT FREEZE! Stable for 12 months at 4 degree C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
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 Preparation and Storage    4 degree C Do not freeze
 Other Notes    Small volumes of anti-ACTA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACTA2 antibody

   Actins are highly conserved proteins expressed in all eucaryotic cells. Actin filaments form part of the cytoskeleton and play essential roles in regulating cell shape and movement. Six distinct actin isotypes have been identified in mammalian cells. Each is encoded by a separated gene and is expressed in a developmentally regulated and tissue-specific manner, alpha and beta cytoplasmic actins are expressed in a wide variety of cells; whereas, expression of alpha skeletal, alpha cardiac, alpha vascular, and gamma enteric actins are more restricted to specialized muscle cell type. Smooth muscle alpha actin is of further interest because it is one of a few genes whose expression is relatively restricted to vascular smooth muscle cells. Further more, expression of smooth muscle alpha actin is regulated by hormones, cell proliferation, and altered by pathological conditions including oncogenic transformation and atherosclerosis.
 Product Categories/Family for anti-ACTA2 antibody    Antibodies; Abs to Actin Related Proteins
 Applications Tested/Suitable for anti-ACTA2 antibody   

Flow Cytometry (FC/FACS)

 Application Notes for anti-ACTA2 antibody    Suitable for use in Flow Cytometry.
Dilution: Flow Cytometry: Neat. 10ul labels up to 1x10e6 cells.
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NCBI/Uniprot data below describe general gene information for ACTA2. It may not necessarily be applicable to this product.
 NCBI GI #    119570540
 NCBI GeneID    59
 NCBI Accession #    EAW50155.1 [Other Products]
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 UniProt Primary Accession #    P62736 [Other Products]
 UniProt Secondary Accession #    P03996; P04108; Q6FI19; B2R8A4 [Other Products]
 UniProt Related Accession #    P62736 [Other Products]
 Molecular Weight    42,009 Da [Similar Products]
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 NCBI Official Full Name    actin, alpha 2, smooth muscle, aorta, isoform CRA_a
 NCBI Official Synonym Full Names    actin, alpha 2, smooth muscle, aorta
 NCBI Official Symbol    ACTA2 [Similar Products]
 NCBI Official Synonym Symbols   
AAT6; ACTSA; MYMY5
[Similar Products]
 NCBI Protein Information    actin, aortic smooth muscle; alpha-cardiac actin; cell growth-inhibiting gene 46 protein
 UniProt Protein Name    Actin, aortic smooth muscle
 UniProt Synonym Protein Names   
Alpha-actin-2; Cell growth-inhibiting gene 46 protein
 Protein Family    Actin
 UniProt Gene Name    ACTA2 [Similar Products]
 UniProt Synonym Gene Names    ACTSA; ACTVS [Similar Products]
 UniProt Entry Name    ACTA_HUMAN
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 NCBI Summary for ACTA2    The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
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 UniProt Comments for ACTA2    ACTA2: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Up-regulated in response to enterovirus 71 (EV71) infection. Belongs to the actin family.

Protein type: Contractile; Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q23.3

Cellular Component: extracellular space; smooth muscle contractile fiber; protein complex; cytoplasm; cytosol; actin cytoskeleton

Molecular Function: protein kinase binding; ATP binding

Biological Process: muscle contraction; response to virus; regulation of blood pressure; vascular smooth muscle contraction

Disease: Multisystemic Smooth Muscle Dysfunction Syndrome; Moyamoya Disease 5; Aortic Aneurysm, Familial Thoracic 6
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 Research Articles on ACTA2    1. the expression of a-smooth muscle actin in periretinal membranes of proliferative vitreoretinopathy (PVR) was related to the grade of PVR
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACTA2 antibodyPathways associated with anti-ACTA2 antibody
 Reference Product  PubMed Publications
 TGFB1 antibody  >109 publications with ACTA2 and TGFB1
 MYH11 antibody  >18 publications with ACTA2 and MYH11
 COL3A1 antibody  >12 publications with ACTA2 and COL3A1
 TAGLN antibody  >8 publications with ACTA2 and TAGLN
 EGFR antibody  >3 publications with ACTA2 and EGFR
 UBC antibody  >1 publications with ACTA2 and UBC
 ACTN2 antibody  >1 publications with ACTA2 and ACTN2
 Products by Pathway  Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Smooth Muscle Contraction Pathway antibodies  Smooth Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
Diseases associated with anti-ACTA2 antibodyOrgans/Tissues associated with anti-ACTA2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >170 publications with ACTA2 and Neoplasms
 Fibrosis Antibodies  >155 publications with ACTA2 and Fibrosis
 Inflammation Antibodies  >44 publications with ACTA2 and Inflammation
 Liver Diseases Antibodies  >41 publications with ACTA2 and Liver Diseases
 Disease Models, Animal Antibodies  >37 publications with ACTA2 and Disease Models, Animal
 Kidney Diseases Antibodies  >34 publications with ACTA2 and Kidney Diseases
 Liver Cirrhosis Antibodies  >29 publications with ACTA2 and Liver Cirrhosis
 Heart Diseases Antibodies  >26 publications with ACTA2 and Heart Diseases
 Breast Neoplasms Antibodies  >25 publications with ACTA2 and Breast Neoplasms
 Aortic Aneurysm, Thoracic Antibodies  >23 publications with ACTA2 and Aortic Aneurysm, Thoracic
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >434 publications with ACTA2 and Muscle
 Vascular Antibodies  >135 publications with ACTA2 and Vascular
 Blood Antibodies  >97 publications with ACTA2 and Blood
 Eye Antibodies  >85 publications with ACTA2 and Eye
 Lung Antibodies  >70 publications with ACTA2 and Lung
 Connective Tissue Antibodies  >68 publications with ACTA2 and Connective Tissue
 Kidney Antibodies  >59 publications with ACTA2 and Kidney
 Liver Antibodies  >55 publications with ACTA2 and Liver
 Skin Antibodies  >42 publications with ACTA2 and Skin
 Embryonic Tissue Antibodies  >39 publications with ACTA2 and Embryonic Tissue
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