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anti-ACTN1 antibody :: Mouse Actinin, alpha 1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS600408 anti-ACTN1 antibody
Unit / Price
0.2 mg  /  $705 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Actinin, alpha 1 (ACTN1), Monoclonal Antibody

 Also Known As   

Actinin, alpha 1 (Non-muscle)

 Product Synonym Names    Anti -Actinin, alpha 1 (Non-muscle)
 Product Gene Name   

anti-ACTN1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 14; NC_000014.8 (69340840..69446083, complement). Location: 14q24.1-q24.2; 14q24; 14q22-q24
 OMIM    102575
 3D Structure    ModBase 3D Structure for P12814
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    0.T.02
 Host    Mouse
 Species Reactivity    Human, Mouse, Rabbit
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 Specificity    Recognizes human alpha-Actinin 1 isoform (non-muscle) at 100kD. Species Crossreactivity: mouse and rabbit
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.6, 0.1% sodium azide.
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 Immunogen    Human alpha-Actinin
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-ACTN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACTN1 antibody

   The cytoplasmic cytoskeleton determines cell organization, shape and adhesion among other functions. Furthermore, the cell type-specific expression of intermediate filaments allows determination of the origin of many, otherwise unspecific tumors.
 Product Categories/Family for anti-ACTN1 antibody    Antibodies; Abs to Actin Related Proteins
 Applications Tested/Suitable for anti-ACTN1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

 Application Notes for anti-ACTN1 antibody    Suitable for use in Western Blot, Immunocytochemistry and Immunohistochemistry. Not suitable for use in Immunoprecipitation.
Dilution: Western Blot: 0.5-2ug/ml. Detects alpha-Actinin in RIPA lysates from human A431 cells.
Immunocytochemistry/Immunohistochemistry: 15ug/ml. Reported positive immunostaining for alpha-Actinin in MRC-5 cells fixed with methanol and also in frozen sections.
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NCBI/Uniprot data below describe general gene information for ACTN1. It may not necessarily be applicable to this product.
 NCBI GI #    30583253
 NCBI GeneID    87
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 UniProt Primary Accession #    P12814 [Other Products]
 UniProt Secondary Accession #    Q9BTN1; B3V8S3; B4DHH3 [Other Products]
 UniProt Related Accession #    P12814; Q1HE25; Q5ZEZ4; Q86TX4 [Other Products]
 Molecular Weight    103,058 Da [Similar Products]
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 NCBI Official Full Name    actinin, alpha 1
 NCBI Official Synonym Full Names    actinin, alpha 1
 NCBI Official Symbol    ACTN1 [Similar Products]
 NCBI Official Synonym Symbols   
FLJ40884; FLJ54432
[Similar Products]
 NCBI Protein Information    alpha-actinin-1; actinin 1 smooth muscle; non-muscle alpha-actinin-1; F-actin cross-linking protein; alpha-actinin cytoskeletal isoform
 UniProt Protein Name    Alpha-actinin-1
 UniProt Synonym Protein Names   
Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1
 Protein Family    Alpha-actinin
 UniProt Gene Name    ACTN1 [Similar Products]
 UniProt Entry Name    ACTN1_HUMAN
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 NCBI Summary for ACTN1    Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for ACTN1    ACTN1: a cytoskeletal protein of the spectrin superfamily. An actin-binding protein with multiple roles in different cell types. A nonmuscle isoform structurally similar to the erythroid beta spectrin gene.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 14q24|14q22-q24

Cellular Component: extracellular space; cortical actin cytoskeleton; focal adhesion; extracellular region; dendritic spine; pseudopodium; fascia adherens; Z disc; cytosol; ruffle; cell projection; cytoplasm; plasma membrane; stress fiber; nucleus

Molecular Function: integrin binding; actin filament binding; protein domain specific binding; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; double-stranded RNA binding; calcium ion binding; vinculin binding

Biological Process: actin crosslink formation; focal adhesion formation; regulation of apoptosis; actin filament bundle formation; platelet activation; extracellular matrix organization and biogenesis; platelet degranulation; negative regulation of cell motility; blood coagulation

Disease: Bleeding Disorder, Platelet-type, 15
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 Research Articles on ACTN1    1. Actinin-1 and cortactin showed matrix-contact-side localization in adenocarcinoma cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACTN1 antibodyPathways associated with anti-ACTN1 antibody
 Reference Product  PubMed Publications
 SRC antibody  >3 publications with ACTN1 and SRC
 VCL antibody  >2 publications with ACTN1 and VCL
 SLC2A4 antibody  >1 publications with ACTN1 and SLC2A4
 PTK2 antibody  >1 publications with ACTN1 and PTK2
 PDLIM1 antibody  >1 publications with ACTN1 and PDLIM1
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-extracellular Matrix Interactions Pathway antibodies  Cell-extracellular Matrix Interactions Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with anti-ACTN1 antibodyOrgans/Tissues associated with anti-ACTN1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >11 publications with ACTN1 and Neoplasms
 Colonic Neoplasms Antibodies  >4 publications with ACTN1 and Colonic Neoplasms
 Colorectal Neoplasms Antibodies  >4 publications with ACTN1 and Colorectal Neoplasms
 Neoplasm Metastasis Antibodies  >4 publications with ACTN1 and Neoplasm Metastasis
 Carcinoma Antibodies  >3 publications with ACTN1 and Carcinoma
 Muscle Neoplasms Antibodies  >2 publications with ACTN1 and Muscle Neoplasms
 Adenoma Antibodies  >2 publications with ACTN1 and Adenoma
 Adenocarcinoma Antibodies  >2 publications with ACTN1 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >2 publications with ACTN1 and Neoplasms, Experimental
 Urologic Neoplasms Antibodies  >2 publications with ACTN1 and Urologic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >12 publications with ACTN1 and Muscle
 Blood Antibodies  >4 publications with ACTN1 and Blood
 Kidney Antibodies  >3 publications with ACTN1 and Kidney
 Heart Antibodies  >3 publications with ACTN1 and Heart
 Embryonic Tissue Antibodies  >3 publications with ACTN1 and Embryonic Tissue
 Brain Antibodies  >3 publications with ACTN1 and Brain
 Prostate Antibodies  >2 publications with ACTN1 and Prostate
 Lung Antibodies  >2 publications with ACTN1 and Lung
 Bladder Antibodies  >2 publications with ACTN1 and Bladder
 Bone Antibodies  >1 publications with ACTN1 and Bone
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