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anti-AICDA antibody :: Mouse Activation-induced Cytidine Deaminase Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS607931 anti-AICDA antibody
Unit / Price
0.1 mL  /  $510 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Activation-induced Cytidine Deaminase (AICDA), Monoclonal Antibody

 Also Known As   

Activation-induced Cytidine Deaminase (AICDA, AID, ARP2, CDA2, HIGM2)

 Product Synonym Names    Anti -Activation-induced Cytidine Deaminase (AICDA, AID, ARP2, CDA2, HIGM2)
 Product Gene Name   

anti-AICDA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (8754762..8765442, complement). Location: 12p13
 3D Structure    ModBase 3D Structure for Q546Y9
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    8k266
 Host    Mouse
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 Specificity    Recognizes human Activation-induced Cytidine Deaminase (AICDA).
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
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 Immunogen    Recombinant human AID (1-54aa) purified from E. coli.
 Hybridoma    Mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human AID protein.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-AICDA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-AICDA antibody

   Activation-induced cytidine deaminase (AID) is an RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. AID deficiency causes the autosomal recessive form of the Hyper-IgM syndrome. Expression of AID is restricted to stimulated B lymphocytes.
 Product Categories/Family for anti-AICDA antibody    Antibodies; Abs to Enzymes
 Applications Tested/Suitable for anti-AICDA antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-AICDA antibody    Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1000-1:2,000
Western Blot: 1:1000-1:2,000
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NCBI/Uniprot data below describe general gene information for AICDA. It may not necessarily be applicable to this product.
 NCBI GI #    10190700
 NCBI GeneID    57379
 NCBI Accession #    NP_065712.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_020661.2 [Other Products]
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 UniProt Primary Accession #    Q546Y9 [Other Products]
 UniProt Related Accession #    Q546Y9; Q5XM85; Q6QHI9; Q6QJ80; Q6QJ81; Q6QLN7; Q7Z599; Q86WB9; Q8NFB5; Q8NFB6 [Other Products]
 Molecular Weight    23,954 Da [Similar Products]
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 NCBI Official Full Name    activation-induced cytidine deaminase
 NCBI Official Synonym Full Names    activation-induced cytidine deaminase
 NCBI Official Symbol    AICDA [Similar Products]
 NCBI Official Synonym Symbols   
AID; ARP2; CDA2; HIGM2
[Similar Products]
 NCBI Protein Information    activation-induced cytidine deaminase; OTTHUMP00000239182; OTTHUMP00000239185; OTTHUMP00000239186; cytidine aminohydrolase; integrated into Burkitt's lymphoma cell line Ramos
 UniProt Protein Name    AID
 Protein Family    Single-stranded DNA cytosine deaminase
 UniProt Gene Name    AID [Similar Products]
 UniProt Synonym Gene Names    AICDA [Similar Products]
 UniProt Entry Name    Q546Y9_HUMAN
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 NCBI Summary for AICDA    This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq]
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 Research Articles on AICDA    1. AID overexpression promotes chromosomal abnormalities and is associated with chronic lymphocytic leukemia progression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-AICDA antibodyPathways associated with anti-AICDA antibody
 Reference Product  PubMed Publications
 RPA1 antibody  >4 publications with AICDA and RPA1
 Products by Pathway  Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
Diseases associated with anti-AICDA antibodyOrgans/Tissues associated with anti-AICDA antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >147 publications with AICDA and Neoplasms
 Leukemia Antibodies  >46 publications with AICDA and Leukemia
 Cell Transformation, Neoplastic Antibodies  >29 publications with AICDA and Cell Transformation, Neoplastic
 Inflammation Antibodies  >17 publications with AICDA and Inflammation
 IMMUNODEFICIENCY WITH HYPER-IgM, TYPE 2 Antibodies  >15 publications with AICDA and IMMUNODEFICIENCY WITH HYPER-IgM, TYPE 2
 Liver Neoplasms Antibodies  >14 publications with AICDA and Liver Neoplasms
 Arthritis, Rheumatoid Antibodies  >11 publications with AICDA and Arthritis, Rheumatoid
 Carcinoma, Hepatocellular Antibodies  >9 publications with AICDA and Carcinoma, Hepatocellular
 Stomach Neoplasms Antibodies  >9 publications with AICDA and Stomach Neoplasms
 Adenocarcinoma Antibodies  >9 publications with AICDA and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >316 publications with AICDA and Blood
 Lymph Node Antibodies  >63 publications with AICDA and Lymph Node
 Kidney Antibodies  >21 publications with AICDA and Kidney
 Lymph Antibodies  >14 publications with AICDA and Lymph
 Tonsil Antibodies  >10 publications with AICDA and Tonsil
 Pharynx Antibodies  >6 publications with AICDA and Pharynx
 Pancreas Antibodies  >1 publications with AICDA and Pancreas
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