NP_001265508.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
57,848 Da
NCBI Official Full Name
activin receptor type-2A isoform 1
NCBI Official Synonym Full Names
activin A receptor, type IIA
NCBI Protein Information
activin receptor type-2A
UniProt Protein Name
Activin receptor type-2A
UniProt Synonym Protein Names
Activin receptor type IIA
UniProt Synonym Gene Names
UniProt Entry Name
AVR2A_HUMAN
NCBI Summary for Activin R2A
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
UniProt Comments for Activin R2A
Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor: Magnesium or manganese
By similarity.
Subunit structure: Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3
By similarity.
Subcellular location: Membrane; Single-pass type I membrane protein.
Sequence similarities: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Contains 1 protein kinase domain.
Research Articles on Activin R2A
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Products associated with anti-Activin R2A antibody
Pathways associated with anti-Activin R2A antibody
Diseases associated with anti-Activin R2A antibody
Organs/Tissues associated with anti-Activin R2A antibody
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