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anti-Activin R2A antibody :: Mouse anti-Human Activin R2A Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS690639
Immunohistochemistry
Unit / Price
0.1 mg  /  $505 +1 FREE 8GB USB
 
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 Product Name   

Activin R2A, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Anti-Human Activin R2A

 Product Synonym Names    Anti human Activin R-2A (#6J16)
 Product Gene Name   

anti-Activin R2A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.12 (147844517..147930827). Location: 2q22.3
 OMIM    102581
 3D Structure    ModBase 3D Structure for P27037
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 Clonality    Monoclonal
 Isotype    IgG2
 Clone Number    (6J16)
 Host    Mouse
 Species Reactivity    Human
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 Specificity    This antibody was selected for its ability to detect human Activin RIIA. No cross reactivity was found to hActivin RI and RIIB.
 Purity/Purification    Protein G affinity chromatography
 Form/Format    Lyophilized
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 Antibody Generation    This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with recombinant human Activin receptor IIA extra cellular domain. IgG2 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.
 Reconstitution    Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
 Protein RefSeq    NP_001607.1
 mRNA RefSeq    NM_001616.3
 Antigen    recombinant human Activin receptor IIA extracellular domain
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 Preparation and Storage    Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-Activin R2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Activin R2A antibody

   Activin proteins are involved in a wide range of biological processes including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis, the regulation of reproductive physiology, inflammation, and carcinogenesis. They function through heteromeric complexes of type I and type II serine/threonine kinase receptors. Dimeric ligands bind to a type II receptor, such as Activin Receptor IIA (ActRIIA or activin R2A), which then associates with a type I receptor to initiate signal transduction. ActRIIA mediates the pleiotropic effects of Activins and Inhibins as well as several members of the BMP and GDF families of TGF beta like proteins. Mature human ActRIIA is a 70 kDa glycoprotein that consists of a 116 amino acid (aa) extracellular domain (ECD), a 26 aa transmembrane segment, and a 352 aa cytoplasmic region that includes the kinase domain and a PDZbinding motif. Within the ECD, human ActRIIA shares 98% aa sequence identity with mouse and rat ActRIIA. Signaling through ActRIIA is modulated by its interaction with RGMB/ DRAGON, Cripto, Endoglin/CD105, TGFbeta RIII/Betaglycan, or BAMBI. These interactions can enhance ligandinduced signaling or interfere with signaling by preventing ActRIIA association with type I receptors. Activininduced responses can also be limited by the enhanced internalization of ActRIIA following its association with the cytoplasmic proteins ARIP1 and ARIP2.
 Applications Tested/Suitable for anti-Activin R2A antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-Activin R2A antibody    WB: 1:500 1:1000
IHC (Paraffin): 1:50 1:100
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 Immunohistochemistry of anti-Activin R2A antibody    Human placenta (formalin fixed and paraffin embedded) section is subjected to IHC
anti-Activin R2A antibody Immunohistochemistry (IHC) image
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NCBI/Uniprot data below describe general gene information for Activin R2A. It may not necessarily be applicable to this product.
 NCBI GI #    518828583
 NCBI GeneID    92
 NCBI Accession #    NP_001265508.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001278579.1 [Other Products]
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 UniProt Primary Accession #    P27037 [Other Products]
 UniProt Secondary Accession #    Q53TH4; Q6NWV2; Q92474; B2RAB8; D3DP85 [Other Products]
 UniProt Related Accession #    P27037 [Other Products]
 Molecular Weight    57,848 Da
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 NCBI Official Full Name    activin receptor type-2A isoform 1
 NCBI Official Synonym Full Names    activin A receptor, type IIA
 NCBI Official Symbol    ACVR2A [Similar Products]
 NCBI Official Synonym Symbols   
ACVR2; ACTRII
[Similar Products]
 NCBI Protein Information    activin receptor type-2A
 UniProt Protein Name    Activin receptor type-2A
 UniProt Synonym Protein Names   
Activin receptor type IIA
 UniProt Gene Name    ACVR2A [Similar Products]
 UniProt Synonym Gene Names    ACVR2; ACTR-IIA; ACTRIIA [Similar Products]
 UniProt Entry Name    AVR2A_HUMAN
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 NCBI Summary for Activin R2A    This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
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 UniProt Comments for Activin R2A    Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Catalytic activity: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor: Magnesium or manganese

By similarity.

Subunit structure: Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3

By similarity.

Subcellular location: Membrane; Single-pass type I membrane protein.

Sequence similarities: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.Contains 1 protein kinase domain.
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 Research Articles on Activin R2A    1. For ACVR2A SNPs (rs10497025, rs1128919, rs13430086), no statistically significant difference was found between preeclampsia and control groups in terms of genotype and allele frequencies.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Activin R2A antibodyPathways associated with anti-Activin R2A antibody
 Reference Product  PubMed Publications
 BMP2 antibody  >5 publications with Activin R2A and BMP2
 BMP7 antibody  >5 publications with Activin R2A and BMP7
 SMAD4 antibody  >1 publications with Activin R2A and SMAD4
 INHA antibody  >1 publications with Activin R2A and INHA
 INHBB antibody  >1 publications with Activin R2A and INHBB
 ACVRL1 antibody  >1 publications with Activin R2A and ACVRL1
 ACVR1B antibody  >1 publications with Activin R2A and ACVR1B
 Products by Pathway  Pathway Diagram
 ALK1 Signaling Events Pathway antibodies  ALK1 Signaling Events Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Regulation Of Signaling By NODAL Pathway antibodies  Regulation Of Signaling By NODAL Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Activin Pathway antibodies  Signaling By Activin Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram
 Signaling By NODAL Pathway antibodies  Signaling By NODAL Pathway Diagram
 TGF-beta Signaling Pathway antibodies  TGF-beta Signaling Pathway Diagram
Diseases associated with anti-Activin R2A antibodyOrgans/Tissues associated with anti-Activin R2A antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with Activin R2A and Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with Activin R2A and Cardiovascular Diseases
 Congenital Abnormalities Antibodies  >3 publications with Activin R2A and Congenital Abnormalities
 Nervous System Diseases Antibodies  >2 publications with Activin R2A and Nervous System Diseases
 Craniofacial Abnormalities Antibodies  >2 publications with Activin R2A and Craniofacial Abnormalities
 Disease Models, Animal Antibodies  >2 publications with Activin R2A and Disease Models, Animal
 Nervous System Malformations Antibodies  >1 publications with Activin R2A and Nervous System Malformations
 Heart Defects, Congenital Antibodies  >1 publications with Activin R2A and Heart Defects, Congenital
 Fibrosis Antibodies  >1 publications with Activin R2A and Fibrosis
 Breast Neoplasms Antibodies  >1 publications with Activin R2A and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >4 publications with Activin R2A and Placenta
 Blood Antibodies  >4 publications with Activin R2A and Blood
 Embryonic Tissue Antibodies  >3 publications with Activin R2A and Embryonic Tissue
 Ovary Antibodies  >3 publications with Activin R2A and Ovary
 Pancreas Antibodies  >2 publications with Activin R2A and Pancreas
 Liver Antibodies  >1 publications with Activin R2A and Liver
 Mammary Gland Antibodies  >1 publications with Activin R2A and Mammary Gland
 Testis Antibodies  >1 publications with Activin R2A and Testis
 Eye Antibodies  >1 publications with Activin R2A and Eye
 Vascular Antibodies  >1 publications with Activin R2A and Vascular
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